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• Clinical Article •
Clinical application of magnetic resonance NODDI in the diagnosis of putamen disease in patients with Parkinson's disease
LIU Weixing  LU Peng  ZHANG Xiaobin  WANG Hong 

Cite this article as: Liu WX, Lu P, Zhang XB, et al. Clinical application of magnetic resonance NODDI in the diagnosis of putamen disease in patients with Parkinson's disease. Chin J Magn Reson Imaging, 2020, 11(8): 610-614. DOI:10.12015/issn.1674-8034.2020.08.003.


[Abstract] Objective: To investigate the clinical value of neurite orientation dispersion and density imaging (NODDI) in patients with Parkinson's disease (PD).Materials and Methods: MRI plain scan and NODDI imaging were performed in 41 PD patients and 22 age and sex matched normal subjects as control group to quantitatively analyze the changes of the putamen in PD patients with Parkinson's disease. The intracellular volume fraction (Vic), directional dispersion index (ODI) and isotropic volume fraction (Viso) of the putamen were compared between the two groups. Multivariate logistic regression analysis was used to determine the independent predictors of PD.Results: The levels of Vic and ODI in the putamen of patients with PD were significantly lower than those in healthy controls. Multivariate logistic analysis showed that the change of Vic in the putamen of patients with PD was significantly correlated with PD (P<0.05), the putamen was an independent predictor of PD. In the ROC analysis, the Vic in the contralateral putamen showed the best diagnostic performance.Conclusions: NODDI may be helpful in the diagnosis PD.
[Keywords] Parkinson disease；magnetic resonance imaging；neurite orientation dispersion and density imaging；putamen

LIU Weixing The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China

LU Peng Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China

ZHANG Xiaobin Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China

WANG Hong* Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China

*Corresponding to: Wang H, E-mail: wangh_xj@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Natural Science Foundation of Xinjiang Uygur Autonomous Region No.2019D01C227
Received  2020-03-12
Accepted  2020-04-12
DOI: 10.12015/issn.1674-8034.2020.08.003
Cite this article as: Liu WX, Lu P, Zhang XB, et al. Clinical application of magnetic resonance NODDI in the diagnosis of putamen disease in patients with Parkinson's disease. Chin J Magn Reson Imaging, 2020, 11(8): 610-614. DOI:10.12015/issn.1674-8034.2020.08.003.

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