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• Clinical Article •
The value of minimum apparent diffusion coefficient value in evaluating Ki-67 proliferation index of adult intracranial ependymoma
LIU Xianwang  HAN Lei  HAO Yan  DENG Juan  LI Shenglin  XUE Caiqiang  ZHANG Xueling  ZHOU Junlin 

Cite this article as: Liu XW, Han L, Hao Y, et al. The value of minimum apparent diffusion coefficient value in evaluating Ki-67 proliferation index of adult intracranial ependymoma. Chin J Magn Reson Imaging, 2020, 11(8): 620-624. DOI:10.12015/issn.1674-8034.2020.08.005.


[Abstract] Objective: To explore the value of minimum apparent diffusion coefficient (ADCmin) value in evaluating Ki-67 proliferation index expression in adult intracranial ependymal tumors.Materials and Methods: A retrospective analysis of the preoperative routine MR and DWI data of 29 adult patients with intracranial ependymoma confirmed by surgical pathology and Ki-67 proliferation index in our hospital from May 2015 to March 2020. The ADCmin value of tumor parenchymal components was measured on the ADC maps, and the correlation between ADCmin value and Ki-67 proliferation index expression was calculated. According to Ki-67 proliferation index value, it was divided into high expression group (Ki-67≥ 10%) and low expression group (Ki-67 <10%), and compare the ADCmin value between the two groups, using receiver operating characteristics (ROC) curve to evaluate the ADCmin value to judge the performance of Ki-67 proliferation index expression level.Results: There was a negative correlation between ADCmin value of adult intracranial ependymal tumor and Ki-67 proliferation index (r=-0.596, P<0.01). The ADCmin value of the Ki-67 proliferation index high expression group was significantly smaller than that of the low expression group. When uses the ADCmin value to identify the high and low expression groups of the Ki-67 proliferation index, the AUC value was 0.897, with 0.871 × 10-3 mm2/s is used as the best discrimination threshold, the sensitivity and specificity of the high and low-level Ki-67 proliferation index are 81.3% and 92.3%, respectively.Conclusions: ADCmin has potential value for non-invasively predicting Ki-67 proliferation index expression level and evaluating its malignancy in adult intracranial ependymal tumors.
[Keywords] ependymal tumor；diffusion weighted imaging；apparent diffusion coefficient；Ki-67；magnetic resonance imaging

LIU Xianwang Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China; Second Clinical School, Lanzhou University, Lanzhou 730030, China; Key Laboratory of Medical Imaging of Gansu Province, Lanzhou 730030, China

HAN Lei Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China; Second Clinical School, Lanzhou University, Lanzhou 730030, China; Key Laboratory of Medical Imaging of Gansu Province, Lanzhou 730030, China

HAO Yan Department of Pathology, Lanzhou University Second Hospital, Lanzhou 730030, China

DENG Juan Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China; Second Clinical School, Lanzhou University, Lanzhou 730030, China; Key Laboratory of Medical Imaging of Gansu Province, Lanzhou 730030, China

LI Shenglin Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China; Second Clinical School, Lanzhou University, Lanzhou 730030, China; Key Laboratory of Medical Imaging of Gansu Province, Lanzhou 730030, China

XUE Caiqiang Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China; Second Clinical School, Lanzhou University, Lanzhou 730030, China; Key Laboratory of Medical Imaging of Gansu Province, Lanzhou 730030, China

ZHANG Xueling Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China; Key Laboratory of Medical Imaging of Gansu Province, Lanzhou 730030, China

ZHOU Junlin* Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China; Second Clinical School, Lanzhou University, Lanzhou 730030, China; Key Laboratory of Medical Imaging of Gansu Province, Lanzhou 730030, China

*Corresponding to: Zhou JL, E-mail: lzuzjl601@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81772006 Health Industry Research Program Funding Project of Gansu Province No. GSWSKY2018-52 Lanzhou University Second Hospital "Cuiying Technology Innovation Plan" Applied Basic Research Project No. CY2017-MS03
Received  2020-04-10
Accepted  2020-05-08
DOI: 10.12015/issn.1674-8034.2020.08.005
Cite this article as: Liu XW, Han L, Hao Y, et al. The value of minimum apparent diffusion coefficient value in evaluating Ki-67 proliferation index of adult intracranial ependymoma. Chin J Magn Reson Imaging, 2020, 11(8): 620-624. DOI:10.12015/issn.1674-8034.2020.08.005.

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