• Clinical Article •
Clinical value study of different post label delay of 3D-ASL and white matter lesion score in vascular cognitive impairment
Cite this article as: Xu C, Wang W. Clinical value study of different post label delay of 3D-ASL and white matter lesion score in vascular cognitive impairment. Chin J Magn Reson Imaging, 2020, 11(8): 630-634. DOI:10.12015/issn.1674-8034.2020.08.007.
| [Abstract] Objective: To study the correlation between different post label delay (PLD) of magnetic resonance 3D arterial spin labeling (3D-ASL) technology, white matter lesions (WMLs) scores and cerebral blood flow (CBF) in vascular cognitive impairment (VCI).Materials and Methods: A total of 52 patients with ischemic cerebrovascular disease diagnosed in the department of neurology were collected. The MoCA scale was used for cognitive function assessment and the patients were divided into the cognitive impairment group (30 cases) and the cognitive normal group (22 cases). the 3D-ASL brain perfusion imaging techniques with different PLD (1.5 s, 2.5 s) was performed, and GE AW4.5 image post-processing software was applied to perform mirror symmetry measurements (CBF1.5, CBF2.5) in bilateral frontal parietal temporal lobe, hippocampus and thalamus. The WMLs scores of the two groups were compared and the correlation between WMLs score /MoCA scale score and CBF values of each brain area.Results: ①The WMLs scores of the VCI group and the control group were 4.87±1.68 and 2.77±1.66, respectively; the scores of the MoCA scale were 18.77±2.98 and 28.18±0.96, respectively, the differences were statistically significant (P=0.000). ②In patients with VCI, CBF1.5 is significantly decreased in the bilateral frontal-temporal lobe, hippocampus, and right thalamus, while CBF2.5 is only reduced in the bilateral frontal-temporal lobe, hippocampus; only the difference between CBF1.5 and CBF2.5 in the left /right frontal lobe was statistically significant (P=0.000/0.019). In all brain regions of all patients, the left and right frontal lobe CBF1.5/CBF2.5 were significantly negatively correlated with WMLs scores (r1.5=-0.567, -0.590/r2.5=-0.553,-0.558; P<0.05). MoCA scale score was positively correlated with CBF1.5 (bilateral frontotemporal lobe, hippocampus, right thalamus) /CBF2.5 (bilateral frontal lobe, hippocampus, left temporal lobe, right thalamus), with the highest frontal lobe correlation (left and right frontal lobe: r1.5=0.806, 0.688/r2.5=0.719, 0.620; P=0.000).Conclusions: PLD1.5 is more sensitive to detection of VCI cerebral hypoperfusion, while PLD2.5 is more accurate in showing the range of hypoperfusion.WMLs was positively correlated with VCI severity. |
| [Keywords] arterial spin labeling；post label delay；cerebral blood flow；white matter lesions；magnetic resonance imaging |
XU Chang Department of MRI, the First Affiliated School of Clinical Medicine of Harbin Medical University, Harbin 150001, China
WANG Wei* Department of MRI, the First Affiliated School of Clinical Medicine of Harbin Medical University, Harbin 150001, China
*Corresponding to: Wang W, E-mail: 1391082196@qq.com
Conflicts of interest None.
| Received 2019-12-02 |
| Accepted 2020-05-21 |
| DOI: 10.12015/issn.1674-8034.2020.08.007 |
| Cite this article as: Xu C, Wang W. Clinical value study of different post label delay of 3D-ASL and white matter lesion score in vascular cognitive impairment. Chin J Magn Reson Imaging, 2020, 11(8): 630-634. DOI:10.12015/issn.1674-8034.2020.08.007. |
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