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• Clinical Article •
Reproducibility of apparent diffusion coefficient in the normal myometrium in proliferating phases and secretory phases
CHEN Bo  LÜ Furong  XIAO Zhibo  SHENG Bo 

Cite this article as: Chen B, Lü FR, Xiao ZB, et al. Reproducibility of apparent diffusion coefficient in the normal myometrium in proliferating phases and secretory phases . Chin J Magn Reson Imaging, 2020, 11(8): 647-650. DOI:10.12015/issn.1674-8034.2020.08.010.


[Abstract] Objective: To evaluate the intra-and inter-observer consistency, reproducibility of the measurement of apparent diffusion coefficient (ADC) values of normal myometrium.Materials and Methods: 34 healthy females (18 in the proliferating phases; 16 in the secretory phases) underwent two MR scanning sessions with an interval of one menstrual cycle (28—32 days). The ADC values of normal myometrium were double-blind measured twice with an interval of one week in each session by two radiologists. Then tested intra-and inter-observer consistency, and analyzed reproducibility of myometrial ADC values in two sessions.Results: Intra-and inter-observer consistency of myometrial ADC values in two missions were both very good, their intraclass correlation coefficients (ICCs) were both greater than 0.75. The myometrial ADC values in the secretory phase were larger than these in the proliferating phase in each session (P<0.05). The ADC values of myometrium in proliferative phase and secretory phase showed no significant difference between the two missions (P>0.05), and further analysis of Bland-Altman found that the 95% confidence intervals in the proliferating phase were-14.3%—13.6% and-11.5%—12.8%, but in the secretory phase were-7.6%—7.0% and-7.7%—7.8%. The reproducibility of ADC value in the secretory phase of myometrium was better than that in the proliferative phase.Conclusions: The intra-and inter-observer consistency of myometrial ADC values measurement are satisfied, these provided more evidence for widely applying in clinic. But reproducibility of normal myometrial ADC values measurement in the secretory phase was better than that in the proliferative phase.
[Keywords] magnetic resonance imaging；apparent diffusion coefficient；myometrium；reproducibility

CHEN Bo Department of Ultrasound, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LÜ Furong* Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

XIAO Zhibo Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

SHENG Bo Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

*Corresponding to: Lü FR, E-mail: lfr918@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Scientific Research Fund for Ministry of Health No.W2014RQ01
Received  2020-02-22
Accepted  2020-06-12
DOI: 10.12015/issn.1674-8034.2020.08.010
Cite this article as: Chen B, Lü FR, Xiao ZB, et al. Reproducibility of apparent diffusion coefficient in the normal myometrium in proliferating phases and secretory phases . Chin J Magn Reson Imaging, 2020, 11(8): 647-650. DOI:10.12015/issn.1674-8034.2020.08.010.

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