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• Clinical Article •
Research on regional homogeneity of resting state functional magnetic resonance imaging in first-episode depressive disorder patients
QIU Jing  WANG Bixin  WANG Lei  XIA Pan  GU Weiguo 

Cite this article as: Qiu J, Wang BX, Wang L, et al. Research on regional homogeneity of resting state functional magnetic resonance imaging in first-episode depressive disorder patients. Chin J Magn Reson Imaging, 2020, 11(9): 721-725. DOI:10.12015/issn.1674-8034.2020.09.001.


[Abstract] Objective: To investigate the alterations of regional homogeneity (ReHo) by the resting-state functional magnetic resonance imaging (rs-fMRI) in first-episode depressive disorder patients, and analyze the relationship between altered ReHo and the scores of 17-item Hamilton Rating Scale for Depression (HAMD-17).Materials and Methods: We analyzed rs-fMRI data obtained from 14 first-episode depressive disorder patients and 16 healthy control subjects. The data were analyzed by the ReHo method, and the differences in ReHo values between the two groups were compared by the two-sample t-test, and the correlation between the HAMD-17 score and the abnormal mean ReHo values of the brain regions in the first-episode major depressive disorder patients was analyzed.Results: Our results showed that patients with depressive disorder had significantly decreased ReHo in the right anterior cingulate and right postcentral gyrus compared with the health control group (corrected by Alphasim, P<0.05 after correction). The mean ReHo of right anterior cingulate gyrus was negatively correlated with HAMD-17 score in patients with first episode of depression (r=-0.566, P=0.035).Conclusions: The ReHo values decreased in the right anterior cingulate and right postcentral gyrus of first-episode depressive disorder patients in the resting state, which may be related to the pathogenesis of depression.
[Keywords] depression；resting-state functional magnetic resonance imaging；brain function

QIU Jing# Department of Radiology, Affiliated Guangji Hospital of Soochow University, Suzhou 215000, China

WANG Bixin# Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China

WANG Lei Department of Radiology, Affiliated Guangji Hospital of Soochow University, Suzhou 215000, China

XIA Pan Department of Radiology, Affiliated Guangji Hospital of Soochow University, Suzhou 215000, China

GU Weiguo* Department of Radiology, Affiliated Guangji Hospital of Soochow University, Suzhou 215000, China

#:Co-first author

*Correspondence to: Gu WG, E-mail: gwgszgj@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the Suzhou Science and Technology Project No. SS201881
Received  2020-02-26
Accepted  2020-07-21
DOI: 10.12015/issn.1674-8034.2020.09.001
Cite this article as: Qiu J, Wang BX, Wang L, et al. Research on regional homogeneity of resting state functional magnetic resonance imaging in first-episode depressive disorder patients. Chin J Magn Reson Imaging, 2020, 11(9): 721-725. DOI:10.12015/issn.1674-8034.2020.09.001.

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