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• Clinical Article •
Application value of 3.0 T MRI pCASL technology in evaluating the curative effect of children with cerebral palsy
WANG Luwei  DU Jinjun  HAN Bingyan 

Cite this article as: Wang LW, Du JJ, Han BY. Application value of 3.0 T MRI pCASL technology in evaluating the curative effect of children with cerebral palsy. Chin J Magn Reson Imaging, 2020, 11(9): 726-729. DOI:10.12015/issn.1674-8034.2020.09.002.


[Abstract] Objective: To explore the application value of 3.0 T pseudo-continuous arterial spin labeling (pCASL) in detecting cerebral blood flow changes and evaluating the efficacy in children with cerebral palsy.Materials and Methods: Thirty children with spasmotic unilateral cerebral palsy who were treated with common carotid artery sympathetic network exfoliation in our hospital from June 2017 to June 2019 were randomly selected as the case group. Thirty healthy children were selected as the normal group. Routine sequence, diagnostic medical imaging (DMI) and pCASL sequences were scanned by 3.0 T MRI on preoperative and 14 d after operation in children of normal group and case group. Data of cerebral blood flow in bilateral frontal lobe, parietal lobe, temporal lobe, central anterior gyrus, basal ganglia and other parts of the brain were obtained through post-processing and statistical analysis.Results: The cerebral blood flow in all parts of the preoperative case group was significantly lower than that of the normal group, and the difference was statistically significant (P<0.05). Each part of the 14 d postoperative cases with cerebral blood flow were improved to varying degrees, among them, the blood flow of the bilateral frontal lobe, temporal lobe, central anterior gyrus, thalamus and cerebellum area of the brain was significantly different from the normal group (P<0.05), parietal lobe and basal ganglia region and internal capsule regional blood flow had no statistically significant difference compared with normal group (P>0.05); the changes of cerebral blood flow before and after the operation were compared among the patients in the case group, and the differences were statistically significant except for the cerebellum (P<0.05).Conclusions: 3.0 T MRI pCASL technique can accurately detect cerebral blood flow in various parts of cerebral palsy children, reflecting the improvement of cerebral ischemia and hypoxia, and has a high application value in the evaluation of the efficacy of common carotid artery adventitia sympathetic network stripping.
[Keywords] cerebral palsy；magnetic resonance imaging；pseudo-continuous arterial spin labeling；cerebral blood flow

WANG Luwei Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumchi 830028, China

DU Jinjun Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumchi 830028, China

HAN Bingyan* Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumchi 830028, China

*Correspondence to: Han BY, E-mail: 182429293@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the Xinjiang Uygur Natural Science Found No. 2019D01C233
Received  2019-12-12
Accepted  2020-07-15
DOI: 10.12015/issn.1674-8034.2020.09.002
Cite this article as: Wang LW, Du JJ, Han BY. Application value of 3.0 T MRI pCASL technology in evaluating the curative effect of children with cerebral palsy. Chin J Magn Reson Imaging, 2020, 11(9): 726-729. DOI:10.12015/issn.1674-8034.2020.09.002.

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