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• Clinical Article •
Differential diagnosis of retroperitoneal peripheral neuroblastic tumors in children by minima apparent diffusion coefficient value of diffusion weighted imaging
REN Xiang  YANG Xiujun 

Cite this article as: Ren X, Yang XJ. Differential diagnosis of retroperitoneal peripheral neuroblastic tumors in children by minima apparent diffusion coefficient value of diffusion weighted imaging. Chin J Magn Reson Imaging, 2020, 11(9): 771-775. DOI:10.12015/issn.1674-8034.2020.09.010.


[Abstract] Objective: To evaluate minimal apparent diffusion coefficient (ADC) value in the differential diagnosis of common retroperitoneal peripheral neuroblastic tumors (pNT) in children.Materials and Methods: Magnetic resonance imaging (MRI) findings of 22 children with retroperitoneal pNTs proved by surgery and pathology were retrospectively analyzed, of which, 5 patients (22.73%) were ganglioneuroma (GN), 7 patients (31.82%) ganglioneuroblastoma (GNB), and 10 patients (45.45%) neuroblastoma (NB). All children underwent plain MRI and diffusion weighted imaging (DWI) before surgery, and 16 of them underwent contrast-enhanced scanning. The minimum ADC value of the parenchymal part of the tumor was measured, and their difference between the three was compared and plotted the receiver operating characteristic (ROC) curve to analyze its diagnostic efficacy.Results: The minimum ADC value of GN was the highest [(1.160±0.310)×10-3 mm2/s], and the minimum ADC value of NB was the lowest [(0.586±0.146)×10-3 mm2/s]. The mean ADC value of GNB was between the above two [(0.794±0.156)×10-3 mm2/s]. There was significant difference among the three groups (F=15.386; P=0.000077). After plotting the ROC curves among the three, the results revealed that the sensitivity of differential diagnosis between GN and GNB was 100% and the specificity was 50% taking the minimum ADC value=0.706×10-3 mm2/s as the cut-off value. Taking a cut-off value of minimum ADC value=0.665×10-3 mm2/s, the sensitivity of differential diagnosis between GNB and NB was 87.5% and the specificity was 80%.Conclusions: The minimal ADC value embraces high clinical value in the differential diagnosis of three common retroperitoneal pNT in children.
[Keywords] neuroblastoma；retroperitoneal space；magnetic resonance imaging；child

REN Xiang Department of Radiology, Shanghai Children’s Hospital, Shanghai Jiaotong University, Shanghai 200062, China

YANG Xiujun* Department of Radiology, Shanghai Children’s Hospital, Shanghai Jiaotong University, Shanghai 200062, China

*Correspondence to: Yang XJ, E-mail: yangxj01@shchildren.com

Conflicts of interest   None.

Received  2020-04-25
Accepted  2020-07-25
DOI: 10.12015/issn.1674-8034.2020.09.010
Cite this article as: Ren X, Yang XJ. Differential diagnosis of retroperitoneal peripheral neuroblastic tumors in children by minima apparent diffusion coefficient value of diffusion weighted imaging. Chin J Magn Reson Imaging, 2020, 11(9): 771-775. DOI:10.12015/issn.1674-8034.2020.09.010.

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