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Correlation analysis between ADC minimum, rADC minimum and Fuhrman classification of renal clear cell carcinoma
ZHANG Jing  LI Shaodong 

Cite this article as: Zhang J, Li SD. Correlation analysis between ADC minimum, rADC minimum and Fuhrman classification of renal clear cell carcinoma. Chin J Magn Reson Imaging, 2020, 11(9): 793-796. DOI:10.12015/issn.1674-8034.2020.09.015.


[Abstract] Objective: To investigate the application value of 3.0 T MRI minimum apparent diffusion coefficient (ADCmin) and relative ADC minimum (rADCmin) in predicting the pathological grades of renal clear cell carcinoma (CCRCC), and compare them with mean apparent diffusion coefficient (ADCmean).Materials and Methods: Retrospective analysis of pathological and DWI data of 92 patients with renal clear cell carcinoma confirmed by surgical pathology. The average and minimum ADC values of the parenchyma of the lesion, and the ADC value of contralateral renal parenchyma were measured, and then the rADCmin was calculated. According to Fuhrman nuclear grading system, Grade Ⅰ and Ⅱ were defined as low-grade group, and grade Ⅲ and Ⅳ were defined as high-grade group. The values of ADCmean, ADCmin, and rADCmin were compared among Ⅰ—Ⅳ pathological grades, and between high-grade group and low-grade group. The correlation between Fuhrman classification and ADC values was analyzed. ROC curve was performed to evaluate the diagnostic efficacy of three different ADC values for high and low grade CCRCC.Results: There were statistically significant differences in ADCmean, ADCmin and rADCmin among the four pathological grades (P<0.05). The ADCmean of the high and low grade groups were (1.578±0.188)×10-3 mm2/s, (1.956±0.206)×10-3 mm2/s, and the ADCmin were (1.291±0.134)×10-3 mm2/s, (1.682±0.223)×10-3 mm2/s, rADCmin were 0.591±0.065, 0.777±0.093 (P<0.01). There was a highly negatively correlated between pathological grades and ADCmean, ADCmin, and rADCmin (r=-0.755, r=-0.826, r=-0.880 respectively, P<0.01); rADCmin had the highest diagnostic effectiveness in identifying high and low grade CCRCC, and the area under ROC was 0.963. With 0.6673 as the best diagnostic threshold, the sensitivity was 91.2% and the specificity was 88.6%.Conclusions: ADCmin is superior to ADCmean in predicting the Fuhrman pathological grades and diagnostic efficacy of renal clear cell carcinoma, and rADCmin has the highest evaluation value, which can provide reference for clinical operation and prognostic evaluation.
[Keywords] kidney neoplasms；magnetic resonance imaging；pathology

ZHANG Jing Department of Medical Imaging, Xuzhou Medical University, Xuzhou 221004, China; Department of Radiology, People's Hospital of Tongshan District, Xuzhou City, Jiangsu Province, Xuzhou 221100, China

LI Shaodong* Department of Radiology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China

*Correspondence to: Li SD, E-mail: 13852003378@163.com

Conflicts of interest   None.

Received  2020-02-09
Accepted  2020-07-15
DOI: 10.12015/issn.1674-8034.2020.09.015
Cite this article as: Zhang J, Li SD. Correlation analysis between ADC minimum, rADC minimum and Fuhrman classification of renal clear cell carcinoma. Chin J Magn Reson Imaging, 2020, 11(9): 793-796. DOI:10.12015/issn.1674-8034.2020.09.015.

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