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Basic principles of intravoxel incoherent motion and diffusional kurtosis imaging and their applications in central nervous system diseases
ZHANG Rui  BAI Yan  WEI Wei  WANG Meiyun 

Cite this article as: Zhang R, Bai Y, Wei W, et al. Basic principles of intravoxel incoherent motion and diffusional kurtosis imaging and their applications in central nervous system diseases. Chin J Magn Reson Imaging, 2020, 11(9): 804-808. DOI:10.12015/issn.1674-8034.2020.09.019.


[Abstract] The new technology of magnetic resonance imaging has great potential in analyzing pathological basis and evaluating changes in brain microstructure. Intravoxel incoherent motion (IVIM) imaging is an emerging non-invasive technique that can simultaneously obtain the diffusion and perfusion information of living tissues. Diffusional kurtosis imaging (DKI) is based on the diffusional weight imaging (DWI) technology, which can quantitatively describe the non-Gaussian motion characteristics of water molecules inside and outside the tissue, reflecting the degree of limited diffusion and the complexity of the microenvironment, providing more real and rich microstructure information. In recent years, IVIM and DKI have achieved considerable preliminary results in many studies, especially showing good application value in the central nervous system. Therefore, this article reviewed the current application progress of IVIM and DKI technology in central nervous system diseases.
[Keywords] magnetic resonance imaging；intravoxel incoherent motion；diffusion kurtosis imaging；central nervous system disease

ZHANG Rui Department of Medical Imaging, the People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou 450003, China; Henan Provincial People's Hospital, Henan Key Laboratory of Neurological Imaging, Zhengzhou 450003, China; Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450000, China

BAI Yan Department of Medical Imaging, the People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou 450003, China; Henan Provincial People's Hospital, Henan Key Laboratory of Neurological Imaging, Zhengzhou 450003, China

WEI Wei Department of Medical Imaging, the People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou 450003, China; Henan Provincial People's Hospital, Henan Key Laboratory of Neurological Imaging, Zhengzhou 450003, China

WANG Meiyun* Department of Medical Imaging, the People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou 450003, China; Henan Provincial People's Hospital, Henan Key Laboratory of Neurological Imaging, Zhengzhou 450003, China

*Correspondence to: Wang MY, E-mail: marian9999@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the National Key Research and Development Program of China No. 2017YFE0103600 National Natural Science Foundation of China No. 81601466, 81720108021 Zhongyuan Thousand Talents Plan Project--Zhongyuan Leader Talent No. ZYQR201810117 Program for Science and Technology Development of Henan Province No. 182102310496 Program for Medical Science and Technology Development of Henan Province No. 2018020403
Received  2020-01-13
Accepted  2020-07-20
DOI: 10.12015/issn.1674-8034.2020.09.019
Cite this article as: Zhang R, Bai Y, Wei W, et al. Basic principles of intravoxel incoherent motion and diffusional kurtosis imaging and their applications in central nervous system diseases. Chin J Magn Reson Imaging, 2020, 11(9): 804-808. DOI:10.12015/issn.1674-8034.2020.09.019.

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