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• Clinical Article •
3.0 T MRI determination of hippocampus volume, olfactory bulb volume and cognitive impairment in Alzheimer' s disease patients
XIONG Xueying  MEI Hao  YE Naili  XIAO Feng  LU Zhiyan 

Cite this article as: Xiong XY, Mei H, Ye NL, et al. 3.0 T MRI determination of hippocampus volume, olfactory bulb volume and cognitive impairment in Alzheimer' s disease patients. Chin J Magn Reson Imaging, 2020, 11(10): 858-861. DOI:10.12015/issn.1674-8034.2020.10.005.


[Abstract] Objective: To explore the correlation of 3.0 T MRI measurement of hippocampal volume, olfactory bulb volume, depth of olfactory groove and cognitive impairment.Materials and Methods: A total of 64 Alzheimer's disease(AD) patients admitted to the Zhongnan Hospital of Wuhan Univercity from October 2017 to December 2019 were selected as AD group. The patients were divided into moderate group (32 cases) and mild group (32 cases) according to Mini-Mental State Examination (MMSE) score, 32 normal healthy subjects were selected as reference, all participants were examined by MMSE and MRI, the data of hippocampus and olfactory bulb were analyzed.Results: The values of cognitive function, hippocampal volume and olfactory bulb volume were the lowest in the moderate group, followed by the mild group, and the highest in the normal group. The differences between the three groups were statistically significant (P=0.000). There was no significant difference in olfactory groove depth between the three groups (P=0.862). The sensitivity and specificity of hippocampal volume and olfactory bulb volume were 0.76/0.78 and 0.92/0.71 respectively.Conclusions: The hippocampus volume and olfactory bulb volume of AD patients decreased with the reduction of cognitive function, and MRI measurement of hippocampus volume was better than that of olfactory bulb.
[Keywords] magnetic resonance imaging；hippocampal volume；olfactory bulb volume；Alzheimer' s disease；depth of olfactory groove；cognitive impairment

XIONG Xueying Medical Imaging Center, the Zhongnan Hospital of Wuhan Univercity, Wuhan 473001, China

MEI Hao Medical Imaging Center, the Zhongnan Hospital of Wuhan Univercity, Wuhan 473001, China

YE Naili Medical Imaging Center, the Zhongnan Hospital of Wuhan Univercity, Wuhan 473001, China

XIAO Feng Medical Imaging Center, the Zhongnan Hospital of Wuhan Univercity, Wuhan 473001, China

LU Zhiyan* Medical Imaging Center, the Zhongnan Hospital of Wuhan Univercity, Wuhan 473001, China

*Correspondence to: Lu ZY, E-mail: luzhiyan@whu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Natural Science Foundation of Hubei Province No. 2013CFB277 Health and Family Planning Research Fund of Hubei Province No. 2017 Wj2017M044 Science and Technology Innovation Cultivation Fund of Zhongnan Hospital of Wuhan University No. znpy2018033
Received  2020-04-24
Accepted  2020-08-21
DOI: 10.12015/issn.1674-8034.2020.10.005
Cite this article as: Xiong XY, Mei H, Ye NL, et al. 3.0 T MRI determination of hippocampus volume, olfactory bulb volume and cognitive impairment in Alzheimer' s disease patients. Chin J Magn Reson Imaging, 2020, 11(10): 858-861. DOI:10.12015/issn.1674-8034.2020.10.005.

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