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• Clinical Article •
Correlation between acute lacunar infarction and asymmetric white matter hyperintensities
BIAN Yitong  SUN Qinli  GAO Lu  YANG Jian 

Cite this article as: Bian YT, Sun QL, Gao L, et al. Correlation between acute lacunar infarction and asymmetric white matter hyperintensities. Chin J Magn Reson Imaging, 2020, 11(10): 862-866. DOI:10.12015/issn.1674-8034.2020.10.006.


[Abstract] Objective: Acute lacunar infarction (ALI) and white matter hyperintensities (WMHs) are important components of cerebral small vessel disease, both closely related. This study intends to explore the effect of asymmetric WMHs on the location of ALI.Materials and Methods: Sixty-one patients (41 were male and 20 were female, with an average age of 65.7±12.6 years) with ALI and WMHs were examined by MRI, including routine imaging, fluid attenuated inversion recovery (FLAIR), diffusion weighted imaging (DWI) and magnetic resonance angiograph (MRA). The WMHs of left and right hemisphere were assessed respectively by modified scheltens scale on FLAIR sequence. The baseline data of symmetric and asymmetric WMHs groups were compared, and to further analyze the correlation between the type of WMHs and the location of ALI.Results: Among the 61 patients, according to WMHs score, 33 cases were in symmetric WMHs group and 28 cases were in asymmetric WMHs group. There were no significant differences in age, sex, body mass index (BMI), hypertension, diabetes, smoking, stroke, homocysteine (Hcy) and onset time between the symmetric and asymmetric groups (P>0.05). There was a significant difference in National Institutes of Health Stroke Scale (NIHSS) at admission between the two groups (P<0.05). In 61 ALI lesions, 34 lesions were located in the left cerebral hemisphere and 27 lesions in the right cerebral hemisphere. There was no significant difference between the cases of left and right hemisphere in the symmetric WMHs group (P>0.05). In left asymmetric WMHs group (13 cases), ALI in the left hemisphere was more than that in the right hemisphere (P<0.05). In right asymmetric WMHs group (15 cases), ALI in the right hemisphere was more than that in the left hemisphere (P<0.05). In addition, most of the ALI in the center of the semicircular circle and the lateral ventricle were located at the edge of the WMHs.Conclusions: Cerebral hemisphere with severe white matter injury is more prone to acute ischemia in patients with asymmetric WMHs, and the ischemic lesion is mostly located on the edge of WMHs.
[Keywords] lacunar；white matter hyperintensities；magnetic resonance imaging；brain asymmetry；stroke

BIAN Yitong Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

SUN Qinli Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

GAO Lu Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

YANG Jian* Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

*Correspondence to: Yang J, E-mail: yj1118@mail.xjtu.edu.cn

Conflicts of interest   None.

Received  2020-03-18
Accepted  2020-05-08
DOI: 10.12015/issn.1674-8034.2020.10.006
Cite this article as: Bian YT, Sun QL, Gao L, et al. Correlation between acute lacunar infarction and asymmetric white matter hyperintensities. Chin J Magn Reson Imaging, 2020, 11(10): 862-866. DOI:10.12015/issn.1674-8034.2020.10.006.

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