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• Clinical Article •
The resting-state fMRI study of interhemispheric voxel-mirrored homotopic connectivity in patients with primary dysmenorrhea
ZHANG Ya'nan  LIU Ni  HAO Ying  WU Junchen  ZHANG Bingyue  XIA Jing  HUANG Yiran  HUO Jianwei 

Cite this article as: Zhang YN, Liu N, Hao Y, et al. The resting-state fMRI study of interhemispheric voxel-mirrored homotopic connectivity in patients with primary dysmenorrhea. Chin J Magn Reson Imaging, 2020, 11(10): 872-876. DOI:10.12015/issn.1674-8034.2020.10.008.


[Abstract] Objective: The present study aimed to investigate interhemispheric voxel-mirrored homotopic connectivity (VMHC) changes in patients with primary dysmenorrhea (PDM) applied by VMHC methods based on resting-state functional magnetic resonance imaging (rs-fMRI).Materials and Methods: Thirty-two patients with PDM and thirty-eight healthy female volunteers were chosen as research object. We collected the clinical data of two groups including basic demographic information, visual analogue scale for pain and anxiety, accompanying symptom score of dysmenorrhea and performed rs-fMRI. The VMHC value differences between two groups were analyzed, while the brain regions with group differences were further used to study correlation with clinical parameters.Results: Compared to the healthy controls, PDM patients demonstrated significantly increased VMHC values in the bilateral subgenual cortex/orbitofrontal region (Gaussian random field corrected, voxel P<0.001, cluster P<0.05, two tailed).Conclusions: Enhanced homotopic connectivity of bilateral subgenual cortex/orbitofrontal region was found in patients with PDM, which may provide a new perspective and objective imaging evidence for the central mechanism of PDM production and regulation.
[Keywords] primary dysmenorrhea；resting-state；functional magnetic resonance imaging；voxel-mirrored homotopic connectivity

ZHANG Ya'nan Department of Radiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

LIU Ni Department of Radiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

HAO Ying Beijing International Center for Mathematical Research, Peking University, Beijing 100871, China

WU Junchen Department of Radiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

ZHANG Bingyue Traditional Chinese Medicine Center, the First Affiliated Hospital of Henan University of TCM, Henan 453000, China

XIA Jing School of Acupuncture Moxibustion & Tuina, Beijing University of Chinese Medicine, Beijing 100029, China

HUANG Yiran* School of Acupuncture Moxibustion & Tuina, Beijing University of Chinese Medicine, Beijing 100029, China

HUO Jianwei* Department of Radiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

*Correspondence to: Huo JW, E-mail: huojw1234@sina.com Huang YR, E-mail: caicai13@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 2015BZHYLL0112
Received  2020-03-30
Accepted  2020-05-09
DOI: 10.12015/issn.1674-8034.2020.10.008
Cite this article as: Zhang YN, Liu N, Hao Y, et al. The resting-state fMRI study of interhemispheric voxel-mirrored homotopic connectivity in patients with primary dysmenorrhea. Chin J Magn Reson Imaging, 2020, 11(10): 872-876. DOI:10.12015/issn.1674-8034.2020.10.008.

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