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• Original Article •
Evaluation the staging of rabbits’ liver fibrosis using diffusion kurtosis imaging: A pilot research
HU Jiawei  LIU Xiaolan  GUO Dongmei  DONG Yang 

Cite this article as: Hu JW, Liu XL, Guo DM, et al. Evaluation the staging of rabbits’ liver fibrosis using diffusion kurtosis imaging: A pilot research. Chin J Magn Reson Imaging, 2020, 11(10): 896-899, 914. DOI:10.12015/issn.1674-8034.2020.10.012.


[Abstract] Objective: To investigate the diagnostic value of the quantitative diffusion kurtosis imaging (DKI) in the staging diagnosis of rabbits’ liver fibrosis.Materials and Methods: Thirty-five healthy male rabbits were divided into experimental group (n=30) and control group (n=5) by subcutaneous injection of 50% CCl4 in olive oil. Rabbit models were scanned by a 3.0 T MR scanner (Discovery MR750W, GE, Healthcare, USA). GE AW4.6 Workstation and SPSS 21.0 help to evaluate the correlation between quantitative analysis of DKI and METAVIR staging.Results: With increasing stage of liver fibrosis, FA, MK value increased (r=0.499, 0.653, P<0.01) and MD value decreased (r=-0.537, P<0.01). And MD value was the best parameter for distinguishing F0 from F1-F2, F0 from F3-F4 with areas under curve (AUC) of 0.886, 0.975 and MK value was the best parameter for distinguishing F1-F2 from F3-F4 with AUC of 0.751 (all P<0.01).Conclusions: DKI related parameters MD and MK have a good application value in the staging diagnosis of rabbits’ liver fibrosis.
[Keywords] magnetic resonance imaging；diffusion kurtosis imaging；liver fibrosis；rabbits；animal experiment

HU Jiawei Department of Radiology, the Second Hospital of Dalian Medical University, Dalian 116027, China

LIU Xiaolan Department of Radiology, the Second Hospital of Dalian Medical University, Dalian 116027, China

GUO Dongmei* Department of Radiology, the Second Hospital of Dalian Medical University, Dalian 116027, China

DONG Yang Department of Radiology, the Second Hospital of Dalian Medical University, Dalian 116027, China

*Correspondence to: Guo DM, E-mail: drguodong@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Natural Science Foundation of Liaoning Province No. 201602228
Received  2019-10-27
Accepted  2020-02-25
DOI: 10.12015/issn.1674-8034.2020.10.012
Cite this article as: Hu JW, Liu XL, Guo DM, et al. Evaluation the staging of rabbits’ liver fibrosis using diffusion kurtosis imaging: A pilot research. Chin J Magn Reson Imaging, 2020, 11(10): 896-899, 914. DOI:10.12015/issn.1674-8034.2020.10.012.

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