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Imaging findings of intravascular lymphoma of central nervous system: Report of 4 cases and literature review
ZHANG Jincai  SHI Chuanying  LI Mingli  YOU Hui  FENG Feng 

Cite this article as: Zhang JC, Shi CY, Li ML, et al. Imaging findings of intravascular lymphoma of central nervous system: Report of 4 cases and literature review. Chin J Magn Reson Imaging, 2020, 11(10): 900-903. DOI:10.12015/issn.1674-8034.2020.10.013.


[Abstract] Objective: To summarize the brain MRI manifestations of intravascular(diffuse large B-cell) lymphoma, improving the understanding of intravascular lymphoma.Materials and Methods: The brain MRI findings of 4 cases of intravascular lymphoma confirmed by skin and brain biopsy were analyzed retrospectively. Combined with the clinical manifestations, laboratory examination, the key features of MRI for diagnosis of intravascular lymphoma were summarized.Results: The clinical manifestations were haemophilus syndrome in 1 case and rapid cognitive decline/progressive dementia in 3 cases. Abnormal brain MRI were displayed in all 4 cases, which showed as multiple lesions with high signal on T2WI, high signal on DWI with slight ADC reduced. The lesions were mainly located in the white matter of bilateral cerebral hemisphere and did not in accordance with the vascular distribution area. In 3 cases, short-term follow-up MRI before biopsy showed that there are always new DWI high signal lesions.Conclusions: When a patient have fever or rapid cognitive decline, and with abnormal brain MR imaging findings, which showed multiple DWI hyperintensity lesions located in brain white matter bilaterally, did not in accordance with the vascular distribution area, with or without ADC reduced, the possibility of intravascular B-cell lymphoma should be highly suspected.
[Keywords] intravascular lymphoma；diffuse large B-cell lymphoma；magnetic resonance imaging；diffusion weighted imaging；apparent diffusion coefficient

ZHANG Jincai Department of Radiology, Central Hospital of Linyi, Linyi 276400, China; Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

SHI Chuanying Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China; Department of Radiology, Liaocheng People’s Hospital, Liaocheng 252000, China

LI Mingli* Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

YOU Hui Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

FENG Feng Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

*Correspondence to: Li ML, E-mail: limingli@pumch.cn

Conflicts of interest   None.

Received  2020-04-24
Accepted  2020-06-23
DOI: 10.12015/issn.1674-8034.2020.10.013
Cite this article as: Zhang JC, Shi CY, Li ML, et al. Imaging findings of intravascular lymphoma of central nervous system: Report of 4 cases and literature review. Chin J Magn Reson Imaging, 2020, 11(10): 900-903. DOI:10.12015/issn.1674-8034.2020.10.013.

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