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Prognostic value of cardiac magnetic resonance-late gadolinium enhancement (CMR-LGE) in patients with end-stage hypertrophic cardiomyopathy
LI Lin  JIANG Yanyan  GUO Shengpeng 

Cite this article as: Li L, Jiang YY, Guo SP. Prognostic value of cardiac magnetic resonance-late gadolinium enhancement (CMR-LGE) in patients with end-stage hypertrophic cardiomyopathy. Chin J Magn Reson Imaging, 2020, 11(10): 911-914. DOI:10.12015/issn.1674-8034.2020.10.016.


[Abstract] Objective: To investigate the prognostic value of cardiac magnetic resonance-late gadolinium enhancement (CMR-LGE) in patients with end-stage hypertrophic cardiomyopathy (ES-HCM).Materials and Methods: One hundred and three patients with ES-HCM in our hospital from August 2015 to November 2019 were enrolled, and divided into two groups according to the absence or presence of LGE, LGE-negative group (n=26) and LGE-positive group (n=77). The clinical symptoms and signs, CMR parameters, and the incidence of major adverse cardiovascular events (MACE) were compared between the two groups.Results: The proportion of palpitations, chest tightness, chest pain, dyspnea, lower extremity edema, syncope, cardiac murmur, and arrhythmia in the LGE-positive group had no significant difference with that of the LGE-negative group (P=0.873, 0.570, 0.916, 0.872, 0.805, 0.981, 0.598, 0.975). The left ventricular maximum wall thickness (LVMWT) in the LGE-positive group was significantly higher than that in the LGE-negative group (P=0.000); the left ventricular ejection fraction (LVEF) in the LGE-positive group was significantly lower than that in the LGE-negative group (P=0.000); Left ventricular end-systolic volume (LVESV), right ventricular ejection fraction (RVEF), left ventricular stroke volume (LVSV), left ventricular end-diastolic volume (LVEDV), right ventricular stroke volume (RVSV), right ventricular end-diastolic volume (RVEDV), left ventricular myocardial mass (LVMM), and right ventricular end-systolic volume (RVESV) had no significant difference between groups (P=0.874, 0.869, 0.929, 0.949, 0.853, 0.918, 0.986, 0.818). During the follow-up period, the incidence of MACE in the LGE-positive group was significantly higher than that in the LGE-negative group (P=0.049).Conclusions: CMR-LGE has certain clinical value in the prognosis assessment of end-stage hypertrophic cardiomyopathy.
[Keywords] cardiac magnetic resonance；late gadolinium enhancement；hypertrophic cardiomyopathy；prognosis assessment；magnetic resonance imaging

LI Lin* Department of Radiology, Wuhan Asia General Hospital, Wuhan 430000, China

JIANG Yanyan Department of Radiology, Wuhan Asia General Hospital, Wuhan 430000, China

GUO Shengpeng Department of Radiology, Wuhan Asia General Hospital, Wuhan 430000, China

*Correspondence to: Li L, E-mail: lilin9940@163.com

Conflicts of interest   None.

Received  2020-03-02
Accepted  2020-06-18
DOI: 10.12015/issn.1674-8034.2020.10.016
Cite this article as: Li L, Jiang YY, Guo SP. Prognostic value of cardiac magnetic resonance-late gadolinium enhancement (CMR-LGE) in patients with end-stage hypertrophic cardiomyopathy. Chin J Magn Reson Imaging, 2020, 11(10): 911-914. DOI:10.12015/issn.1674-8034.2020.10.016.

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