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• Clinical Article •
Degree centrality of brain network in heroin addicts treated with methadone maintenance: a resting-state functional magnetic resonance imaging study
XUE Jiuhua  CHEN Jiajie  CAI Guanke  SHI Hong  LIU Wei  LIU Yan  MENG Yan  LI Wei  WANG Wei  LI Qiang 

Cite this article as: Xue JH, Chen JJ, Cai GK, et al. Degree centrality of brain network in heroin addicts treated with methadone maintenance: a resting-state functional magnetic resonance imaging study. Chin J Magn Reson Imaging, 2020, 11(11): 961-965. DOI:10.12015/issn.1674-8034.2020.11.001.


[Abstract] Objective: To explore the effect of methadone maintenance treatment on the core nodes of the brain network of heroin addicts.Materials and Methods: Twenty-six heroin addicts during short-term abstinence (HA), 25 heroin addicts during methadone maintenance treatment (MMT) and 42 health controls (HC) were recruited. The resting-state fMRI data of all subjects were collected. Based on the theory of graph theory, the degree centrality (DC) of whole brains of the three groups were compared. The correlations between the DC values and history of heroin addiction and MMT were also analyzed.Results: The DC value of left medial frontal cortex and bilateral inferior parietal lobules in MMT and HC group was significantly lower than that in HA group. The DC value of left anterior precuneus lobe in MMT group was significantly higher than that in HC group. It was found that the DC value of left orbital frontal gyrus and left middle frontal gyrus in HA group and MMT group was significantly higher than that in HC group. The right insular lobe in MMT group was significantly lower than that in HC group and HA group (P<0.001, P<0.05 after Alphasim correction, voxels> 25).Conclusions: The methadone maintenance treatment is beneficial to the recovery of self-awareness, self-monitoring of heroin addicts. However, there are still some abnormalities such as salience, decision-making and inhibitory control, which may take longer or other comprehensive interventions to recover.
[Keywords] methadone maintenance treatment；heroin addiction；degree of centrality；brain network；functional magnetic resonance

XUE Jiuhua Department of Radiology, Tangdu Hospital, Air Force military Medical University, Xi'an 710038, China; Department of Radiology, Xi'an First Hospital, Xi'an 710002, China

CHEN Jiajie Department of Radiology, Tangdu Hospital, Air Force military Medical University, Xi'an 710038, China

CAI Guanke Department of Radiology, Tangdu Hospital, Air Force military Medical University, Xi'an 710038, China

SHI Hong Department of Radiology, Tangdu Hospital, Air Force military Medical University, Xi'an 710038, China; Department of Radiology, Xi'an First Hospital, Xi'an 710002, China

LIU Wei Department of Radiology, Tangdu Hospital, Air Force military Medical University, Xi'an 710038, China; Department of Radiology, Xi'an First Hospital, Xi'an 710002, China

LIU Yan Department of Radiology, Tangdu Hospital, Air Force military Medical University, Xi'an 710038, China

MENG Yan Department of Advertisinng , Shaanxi Youth Vocational College, Xi'an 710068, China

LI Wei Department of Radiology, Tangdu Hospital, Air Force military Medical University, Xi'an 710038, China

WANG Wei Department of Radiology, Tangdu Hospital, Air Force military Medical University, Xi'an 710038, China

LI Qiang* Department of Radiology, Tangdu Hospital, Air Force military Medical University, Xi'an 710038, China

*Correspondence to: Li Q, E-mail: tdqiangqiang@foxmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  National Natural Science Foundation of China No. 81671661
Received  2020-06-01
Accepted  2020-09-28
DOI: 10.12015/issn.1674-8034.2020.11.001
Cite this article as: Xue JH, Chen JJ, Cai GK, et al. Degree centrality of brain network in heroin addicts treated with methadone maintenance: a resting-state functional magnetic resonance imaging study. Chin J Magn Reson Imaging, 2020, 11(11): 961-965. DOI:10.12015/issn.1674-8034.2020.11.001.

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