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• Clinical Article •
Amplitude of low-frequency fluctuations of resting-state functional MRI in multiple system atrophy patients with depression
HU Lanhua  LI Tao  YANG Wenbing  ZHA Yunfei 

Cite this article as: Hu LH, Li T, Yang WB, et al. Amplitude of low-frequency fluctuations of resting-state functional MRI in multiple system atrophy patients with depression. Chin J Magn Reson Imaging, 2020, 11(11): 966-970. DOI:10.12015/issn.1674-8034.2020.11.002.


[Abstract] Objective: To investigate the changes of resting-state spontaneous brain activity in multiple system atrophy patients with depression.Materials and Methods: Thirty-two MSA patients with depression symptom, twenty-six patients without depression and thirty-nine health controls were enrolled. All the participants underwent 3.0 T MRI resting-state blood oxygen level dependence sequence scan. Two sample t-test was used to compare the differences of the whole brain amplitude of low-frequency fluctuations (ALFF) among the three groups, and the correlation between the different brain areas and Hamilton depression score was analyzed.Results: Compared with the HC groups, MSA-D (MSA patients with depressive symptoms) shows more widely brain areas dysfunction which included right inferior temporal gyrus, bilateral putamen, right superior frontal gyrus, left middle frontal gyrus, bilateral middle occipital gyrus, left precuneus and left middle cingulate cortex than MSA-ND (MSA- no depressive symptoms). A directly comparison of the two patient groups, MSA-D shows increase ALFF in right middle temporal gyrus and right middle occipital gyrus. There was a positive correlation between the ALFF value of right middle temporal gyrus and clinical HAMD-24 score (r=-0.511, P=0.003).Conclusions: There is a wide range of resting state brain activity in MSA patients with depressive symptoms, and increased ALFF activity in the right middle temporal gyrus may be a potential biomarker for depressive symptoms in MSA.
[Keywords] multiple system atrophy；depression；magnetic resonance imaging；amplitude of low-frequency fluctuations

HU Lanhua Department of Radiology, Renmin Hospital of Wuhan University in Hubei Province, Wuhan 430060, China

LI Tao Department of Radiology, Renmin Hospital of Wuhan University in Hubei Province, Wuhan 430060, China

YANG Wenbing Department of Radiology, Renmin Hospital of Wuhan University in Hubei Province, Wuhan 430060, China

ZHA Yunfei* Department of Radiology, Renmin Hospital of Wuhan University in Hubei Province, Wuhan 430060, China

*Correspondence to: Zha YF, E-mail: zhayunfei999@126.com

Conflicts of interest   None.

Received  2020-05-19
Accepted  2020-09-28
DOI: 10.12015/issn.1674-8034.2020.11.002
Cite this article as: Hu LH, Li T, Yang WB, et al. Amplitude of low-frequency fluctuations of resting-state functional MRI in multiple system atrophy patients with depression. Chin J Magn Reson Imaging, 2020, 11(11): 966-970. DOI:10.12015/issn.1674-8034.2020.11.002.

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