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• Clinical Article •
Magnetic resonance imaging on morphological abnormalities of brain in 1—3 years old children with autism spectrum disorder
LIU Bingguang  CAO Manrui  ZHU Zhijun  LIU Yang  WAN Guobin 

Cite this article as: Liu BG, Cao MR, Zhu ZJ, et al. Magnetic resonance imaging on morphological abnormalities of brain in 1—3 years old children with autism spectrum disorder. Chin J Magn Reson Imaging, 2020, 11(11): 990-993, 998. DOI:10.12015/issn.1674-8034.2020.11.007.


[Abstract] Objective: To analyze morphological abnormalities of brain in 1—3 years old children with autism spectrum disorder (ASD) based on voxel-based morphometry (VBM), and to explore the feasibility of early diagnosis of ASD by magnetic resonance imaging (MRI) preliminarily.Materials and Methods: One to three years old children diagnosed first with ASD and age and gender matched normal children were scanned by MRI with high resolution 3D T1WI. Based on the statistical parameter graph (SPM12) with toolkit CAT12 of matlab2012b, VBM was used to analyze 3D T1WI images and the volume of each brain regions were calculated. The two sample t test was used to analyze differences of the volume of the whole brain and each brain regions.Results: There were eligible 17 cases in ASD group [All were male, with an average age of (28.9±9.5) months ranging from 12 to 34 months] and 12 cases in control group [All were male, with an average age of (28.6±10.5) months ranging from 13 to 35 months]. Compared with the control, the gray matter volume and cerebral cortex thickness of the ASD group were larger, and the cerebrospinal fluid volume was smaller (P<0.05).The volume of gray matter in left posterior central gyrus, right inferior parietal gyrus and left inferior frontal gyrus were showed increased in 1—3 years old children with ASD (P<0.001, Nuclear group> 100 voxels).Conclusions: There are certain characteristics of morphological abnormalities of brain in 1—3 years old children with ASD. MRI is expected to be a method of early diagnosis of ASD.
[Keywords] autism spectrum disorder；magnetic resonance imaging；voxel-based morphometry；early diagnosis

LIU Bingguang Department of Radiology, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China

CAO Manrui* Department of Radiology, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China

ZHU Zhijun Department of Radiology, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China

LIU Yang Department of Radiology, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China

WAN Guobin Department of Child Psychology and Rehabilitation, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China

*Correspondence to: Cao MR, lbg379@163.com

Conflicts of interest   None.

Received  2020-06-29
Accepted  2020-09-30
DOI: 10.12015/issn.1674-8034.2020.11.007
Cite this article as: Liu BG, Cao MR, Zhu ZJ, et al. Magnetic resonance imaging on morphological abnormalities of brain in 1—3 years old children with autism spectrum disorder. Chin J Magn Reson Imaging, 2020, 11(11): 990-993, 998. DOI:10.12015/issn.1674-8034.2020.11.007.

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