Share：
Share this content in WeChat
X
[Chinese][PDF]934162
• Clinical Article •
Study on the correlation between MRI features and KRAS status of rectal cancers before operation
JIANG Xueqin  YAN Chenchen  ZHOU Zhengyang 

Cite this article as: Jiang XQ, Yan CC, Zhou ZY. Study on the correlation between MRI features and KRAS status of rectal cancers before operation. Chin J Magn Reson Imaging, 2020, 11(11): 1004-1009. DOI:10.12015/issn.1674-8034.2020.11.010.


[Abstract] Objective: To analyze whether the MRI features of rectal cancers can predict Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) mutation status.Materials and Methods: Eighty-two patients who were confirmed to have rectal cancers by surgery and pathology and had undergone KRAS gene examination were collected retrospectively. The patients were divided into a mutant group and a wild-type group according to the mutation status of KRAS gene. Two doctors analyzed their MRI characteristics, including tumor location, gross morphology, periintestinal involvement, circumferential margin (CRM), tumor maximum longitudinal length (LTL), tumor maximum axial length (ATL), maximum axial length/maximum longitudinal length (ATL/LTL), ADC value, etc., and then analyze whether there are differences between the two groups.Results: The KRAS mutant group and the wild-type group had significant differences in tumor morphology, ATL and ATL/LTL (χ2=11.815, P=0.001; Z=-2.268, P=0.023; Z=-2.422, P=0.015). Larger ATL/LTL were more prone to KRAS gene mutation. ROC analysis between the two groups showed that the area under the curve (AUC) of ATL and ATL/LTL were 0.645 and 0.655, respectively.Conclusions: There were significant differences in ATL and ATL/LTL between KRAS mutant group and wild type group.
[Keywords] magnetic resonance imaging；rectal cancer；KRAS mutation；case-control studies

JIANG Xueqin Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China

YAN Chenchen Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China

ZHOU Zhengyang* Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China

*Correspondence to: Zhou ZY, E-mail: zyzhou@nju.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the National Natural Science Foundation of China No. 81871410, 81671751
Received  2020-06-10
Accepted  2020-09-28
DOI: 10.12015/issn.1674-8034.2020.11.010
Cite this article as: Jiang XQ, Yan CC, Zhou ZY. Study on the correlation between MRI features and KRAS status of rectal cancers before operation. Chin J Magn Reson Imaging, 2020, 11(11): 1004-1009. DOI:10.12015/issn.1674-8034.2020.11.010.

[1]
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424. DOI: 10.3322/caac.21492
[2]
Russo AL, Borger DR, Szymonifka J, et al. Mutational analysis and clinical correlation of metastatic colorectal cancer. Cancer, 2014, 120(10): 1482-1490. DOI: 10.1002/cncr.28599
[3]
Sorich MJ, Wiese MD, Rowland A, et al. Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of randomized, controlled trials. Ann Oncol, 2015, 26(1): 13-21. DOI: 10.1093/annonc/mdu378
[4]
丁莉，韩义明，郑杰，等．结直肠癌中KRAS基因突变及意义．临床与实验病理学杂志, 2016, 32(10): 1156-1159. DOI: 10.13315/j.cnki.cjcep.2016.10.019
[5]
Nakanishi R, Harada J, Tuul M, et al. Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer. Int J Clin Oncol, 2013, 18(6): 1042-1048. DOI: 10.1007/s10147-012-0501-x
[6]
Boeckx N, Peeters M, Van Camp G, et al. Prognostic and predictive value of RAS gene mutations in colorectal cancer: moving beyond KRAS exon 2. Drugs, 2015, 75(15): 1739-1756. DOI: 10.1007/s40265-015-0459-x
[7]
Hardiman KM. Update on sporadic colorectal cancer genetics. Clin Colon Rectal Surg, 2018, 31(3): 147-152. DOI: 10.1055/s-0037-1602234
[8]
Baldus SE, Schaefer KL, Engers R, et al. Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases. Clin Cancer Res, 2010, 16(3): 790-799. DOI: 10.1158/1078-0432.CCR-09-2446
[9]
Sclafani F, Wilson SH,Cunningham D, et al. Analysis of KRAS, NRAS, BRAF, PIK3CA and TP53 mutations in a large prospective series of locally advanced rectal cancer patients. Int J Cancer, 2020, 146(1): 94-102. DOI: 10.1002/ijc.32507
[10]
Sievers CK, Grady WM, Halberg RB, et al. New insights into the earliest stages of colorectal tumorigenesis. Expert Rev Gastroenterol Hepatol, 2017, 11(8): 723-729. DOI: 10.1080/17474124.2017.1330150
[11]
刘靖，李志霞，安大立，等．结直肠癌循环肿瘤DNA基因突变特征及与组织一致性分析．中国临床医生杂志, 2019, 47(2): 190-193. DOI: 10.3969/j.issn.2095-8552.2019.02.019
[12]
宋新红，王培源. MRI新技术在直肠癌临床应用研究进展．磁共振成像, 2018, 9(7): 550-555. DOI: 10.12015/issn.1674-8034.2018.07.012
[13]
廖雪芮，张修石，张红霞. MR弥散加权成像ADC值与直肠癌临床病理因素的相关性．中国肿瘤, 2016, 25(1): 76-80. DOI: 10.11735/j.issn.1004-0242.2016.01.A014
[14]
苟文枭. DCE-MRI定量参数及ADC值评估直肠癌分化程度、T分期、淋巴结转移情况的应用价值研究．西南医科大学, 2018.
[15]
余静．功能MR成像在直肠癌新辅助放化疗疗效评估以及预后评估中的应用价值．南京医科大学, 2017.
[16]
Oh JE, Kim MJ, Lee J, et al. magnetic resonance-based texture analysis differentiating KRAS mutation status in rectal cancer. Cancer Res Treat, 2020, 52(1): 51-59. DOI: 10.4143/crt.2019.050
[17]
Meng X, Xia W, Xie P, et al. Preoperative radiomic signature based on multiparametric magnetic resonance imaging for noninvasive evaluation of biological characteristics in rectal cancer. Eur Radiol, 2019, 29(6): 3200-3209. DOI: 10.1007/s00330-018-5763-x
[18]
王灵华．直肠癌分子表型与功能MRI定量参数的相关性研究．苏州大学, 2018.
[19]
Xu Y, Xu Q, Sun H, et al. Could IVIM and ADC help in predicting the KRAS status in patients with rectal cancer? Eur Radiol, 2018, 28(7): 3059-3065. DOI: 10.1007/s00330-018-5329-y
[20]
Cui Y, Cui X, Yang X, et al. Diffusion kurtosis imaging-derived histogram metrics for prediction of KRAS mutation in rectal adenocarcinoma: Preliminary findings. J Magn Reson Imaging, 2019, 50(3): 930-939. DOI: 10.1002/jmri.26653
[21]
Shin YR, Kim KA, Im S, et al. Prediction of KRAS mutation in rectal cancer using MRI. Anticancer Res, 2016, 36(9): 4799-4804. DOI: 10.21873/anticanres.11039
[22]
Jo SJ, Kim SH. Association between oncogenic RAS mutation and radiologic-pathologic findings in patients with primary rectal cancer. Quant Imaging Med Surg, 2019, 9(2): 238-246. DOI: 10.21037/qims.2018.12.10
[23]
Yamagata S, Muto T, Uchida Y, et al. Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas. Jpn J Cancer Res, 1994, 85(2):147-151. DOI: 10.1111/j.1349-7006.1994.tb02075.x
[24]
Yashiro M, Carethers JM, Laghi L, et al. Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. Cancer Res, 2001, 61(6): 2676-2683.
[25]
Voorham QJ, Rondagh EJ, Knol DL, et al. Tracking the molecular features of nonpolypoid colorectal neoplasms: a systematic review and meta-analysis. Am J Gastroenterol, 2013, 108(7):1042-1056. DOI: 10.1038/ajg.2013.126
[26]
Umetani N, Sasaki S, Masaki T, et al. Involvement of APC and K-ras mutation in non-polypoid colorectal tumorigenesis. Br J Cancer, 2000, 82(1): 9-15. DOI: 10.1054/bjoc.1999.0869
[27]
Sun Y, Tong T, Cai S, et al. Apparent diffusion coefficient (ADC) value: a potential imaging biomarker that reflects the biological features of rectal cancer. PLoS One, 2014, 9(10): e109371. DOI: 10.1371/journal.pone.0109371
[28]
Surov A, Meyer HJ, Wienke A. Associations between apparent diffusion coefficient (ADC) and KI 67 in different tumors: a meta-analysis. Part 1: ADCmean. Oncotarget, 2017, 8(43): 75434-75444. DOI: 10.18632/oncotarget.20406
[29]
Xu Y, Xu Q, Ma Y, et al. Characterizing MRI features of rectal cancers with different KRAS status. BMC Cancer, 2019, 19(1): 1111. DOI: 10.1186/s12885-019-6341-6
[30]
Kim JH, Beets GL, Kim MJ, et al. Beets-Tan RG. High-resolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size? Eur J Radiol, 2004, 52(1): 78-83. DOI: 10.1016/j.ejrad.2003.12.005

PREV Cardiac magnetic resonance right ventricular myocardial strain was applied to normal smoking population: a pilot study
NEXT Magnetic resonance imaging as a tool to predict pathological complete response of rectal cancer after neoadjuvant chemoradiotherapy: a Meta-analysis
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn