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Application of resting state fMRI in the study of the obstructive sleep apnea-hypopnea syndrome
WANG Qin  XIONG Yanxi  CHEN Guangbin  AO Feng  ZOU Wenyuan 

Cite this article as: Wang Q, Xiong YX, Chen GB, et al. Application of resting state fMRI in the study of the obstructive sleep apnea-hypopnea syndrome. Chin J Magn Reson Imaging, 2020, 11(11): 1051-1055. DOI:10.12015/issn.1674-8034.2020.11.022.


[Abstract] Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common disease with chronic multi-system damage. The central nervous system (CNS) damage of OSAHS is mainly manifested as cognitive impairment and neuropsychiatric abnormality, which seriously affects the quality of life and safety of patients. However, the neuropathological mechanism of OSAHS has not been fully elucidated. Recently, resting state functional magnetic resonance imaging (rs-fMRI) and its advanced data processing methods have opened a new way for the study of OSAHS neuroimaging. This article makes a review to explore the potential neuropathic mechanisms of CNS damage in OSAHS patients and to provide valuable methods and evidence for early diagnosis and treatment.
[Keywords] obstructive sleep apnea；central nervous system；functional magnetic resonance imaging；resting state

WANG Qin Department of Radiologic center, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China; Radiology center of Shiyan Renmin Hospital of Hubei Province, Shiyan 442000, China; Institute of Radiology, Shiyan Renmin Hospital, Hubei Province, Shiyan 442000, China

XIONG Yanxi Department of Radiologic center, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China; Radiology center of Shiyan Renmin Hospital of Hubei Province, Shiyan 442000, China; Institute of Radiology, Shiyan Renmin Hospital, Hubei Province, Shiyan 442000, China

CHEN Guangbin Department of Radiologic center, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China; Radiology center of Shiyan Renmin Hospital of Hubei Province, Shiyan 442000, China; Institute of Radiology, Shiyan Renmin Hospital, Hubei Province, Shiyan 442000, China

AO Feng Radiology center of Shiyan Renmin Hospital of Hubei Province, Shiyan 442000, China; Institute of Radiology, Shiyan Renmin Hospital, Hubei Province, Shiyan 442000, China

ZOU Wenyuan* Department of Radiologic center, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China; Radiology center of Shiyan Renmin Hospital of Hubei Province, Shiyan 442000, China; Institute of Radiology, Shiyan Renmin Hospital, Hubei Province, Shiyan 442000, China

*Correspondence to: Zou WY, E-mail: 778229446@qq.com

Conflicts of interest   None.

Received  2020-06-11
Accepted  2020-09-28
DOI: 10.12015/issn.1674-8034.2020.11.022
Cite this article as: Wang Q, Xiong YX, Chen GB, et al. Application of resting state fMRI in the study of the obstructive sleep apnea-hypopnea syndrome. Chin J Magn Reson Imaging, 2020, 11(11): 1051-1055. DOI:10.12015/issn.1674-8034.2020.11.022.

[1]
Levy P, Kohler M, McNicholas WT, et al. Obstructive sleep apnoea syndrome. Nat Rev Dis Primers, 2015, 1(15015): 1-20. DOI: 10.1038/nrdp.2015.15
[2]
Morsy NE, Farrag NS, Zaki N, et al. Obstructive sleep apnea: personal, societal, public health, and legal implications. Rev Environ Health, 2019, 34(2): 153-169. DOI: 10.1515/reveh-2018-0068
[3]
Bucks RS, Olaithe M, Rosenzweig I, et al. Reviewing the relationship between OSA and cognition: where do we go from here. Respirology, 2017, 22(7): 1253-1261. DOI: 10.1111/resp.13140
[4]
Patel SR. Obstructive sleep apnea. Ann Intern Med, 2019, 171(11): ITC81-81ITC96. DOI: 10.7326/AITC201912030
[5]
Purtle MW, Renner CH, McCann DA, et al. Driving with undiagnosed obstructive sleep apnea (OSA): High prevalence of OSA risk in drivers who experienced a motor vehicle crash. Traffic Inj Prev, 2020, 21(1): 38-41. DOI: 10.1080/15389588.2019.1709175
[6]
Gupta MA, Simpson FC. Obstructive sleep apnea and psychiatric disorders: a systematic review. J Clin Sleep Med, 2015, 11(2): 165-175. DOI: 10.5664/jcsm.4466
[7]
Ferini-Strambi L, Lombardi GE, Marelli S, et al. Neurological deficits in obstructive sleep apnea. Curr Treat Options Neurol, 2017, 19(4): 16. DOI: 10.1007/s11940-017-0451-8
[8]
Bubu OM, Andrade AG, Umasabor-Bubu OQ, et al. Obstructive sleep apnea, cognition and Alzheimer's disease: a systematic review integrating three decades of multidisciplinary research. Sleep Med Rev, 2020, 50(101250):1-23. DOI: 10.1016/j.smrv.2019.101250
[9]
Walia HK. Beyond heart health: consequences of obstructive sleep apnea. Cleve Clin J Med, 2019, 86(9Suppl 1): 19-25. DOI: 10.3949/ccjm.86.s1.04
[10]
Khazaie H, Veronese M, Noori K, et al. Functional reorganization in obstructive sleep apnoea and insomnia: a systematic review of the resting-state fMRI. Neurosci Biobehav Rev, 2017, 77: 219-231. DOI: 10.1016/j.neubiorev.2017.03.013
[11]
秦粽园，鲍海华，吴有森，等．阻塞性睡眠呼吸暂停低通气综合征的脑结构及脑静息态fMRI研究．磁共振成像, 2017, 8(11): 854-860. DOI: 10.12015/issn.1674-8034.2017.11.011
[12]
Huang X, Tang S, Lyu X, et al. Structural and functional brain alterations in obstructive sleep apnea: a multimodal meta-analysis. Sleep Med, 2019, 54: 195-204. DOI: 10.1016/j.sleep.2018.09.025
[13]
Tsai MS, Li HY, Huang CG, et al. Risk of alzheimer's disease in obstructive sleep apnea patients with or without treatment: real-world evidence. Laryngoscope, 2020, 130(9): 2292-2298. DOI: 10.1002/lary.28558
[14]
Wang Y, Cheng C, Moelter S, et al. One year of continuous positive airway pressure adherence improves cognition in older adults with mild apnea and mild cognitive impairment. Nurs Res, 2020, 69(2): 157-164. DOI: 10.1097/NNR.0000000000000420
[15]
杜小霞，秦朝霞．磁共振功能成像回顾与展望．磁共振成像, 2019, 10(10): 721-726. DOI: 10.12015/issn.1674-8034.2019.10.001
[16]
Smitha KA, Akhil Raja K, Arun KM, et al. Resting state fMRI: a review on methods in resting state connectivity analysis and resting state networks. Neuroradiol J, 2017, 30(4): 305-317. DOI: 10.1177/1971400917697342
[17]
Cantou P, Platel H, Desgranges B, et al. How motor, cognitive and musical expertise shapes the brain: focus on fMRI and EEG resting-state functional connectivity. J Chem Neuroanat, 2018, 89: 60-68. DOI: 10.1016/j.jchemneu.2017.08.003
[18]
陈怡，余成新．基于静息态功能磁共振成像的静态及动态功能连接分析方法研究进展．磁共振成像, 2019, 10(8): 637-640. DOI: 10.12015/issn.1674-8034.2019.08.017
[19]
Wan XY, Zhao WR, Wu XR, et al. The brain imaging studies of obstructive sleep apnea: evidence from resting-state EEG and fMRI. Sheng Li Xue Bao, 2019, 71(5): 760-768.
[20]
张泉．阻塞性睡眠呼吸暂停低通气综合征的静息态脑功能磁共振成像研究．天津医科大学, 2012.
[21]
Santarnecchi E, Sicilia I, Richiardi J, et al. Altered cortical and subcortical local coherence in obstructive sleep apnea: a functional magnetic resonance imaging study. J Sleep Res, 2013, 22(3): 337-347. DOI: 10.1111/jsr.12006
[22]
Peng DC, Dai XJ, Gong HH, et al. Altered intrinsic regional brain activity in male patients with severe obstructive sleep apnea: a resting-state functional magnetic resonance imaging study. Neuropsychiatr Dis Treat, 2014, 10: 1819-1826. DOI: 10.2147/NDT.S67805
[23]
Li HJ, Dai XJ, Gong HH, et al. Aberrant spontaneous low-frequency brain activity in male patients with severe obstructive sleep apnea revealed by resting-state functional MRI. Neuropsychiatr Dis Treat, 2015, 11: 207-214. DOI: 10.2147/NDT.S7373
[24]
Chen T, Yang M, Liu B, et al. Regional homogeneity changes in patients with obstructive sleep apnea-hypopnea syndrome: resting-state functional MRI study]. Zhonghua Yi Xue Za Zhi, 2016, 96(11): 868-873. DOI: 10.3760/cma.j.issn.0376-2491.2016.11.009
[25]
李海军，彭德昌，龚洪翰，等．阻塞性睡眠呼吸暂停综合征患者频率依赖的低频振幅的静息态功能磁共振研究．临床放射学杂志, 2016, 35(3): 323-327. DOI: 10.13437/j.cnki.jcr.2016.03.003
[26]
秦粽园，鲍海华，康东杰，等．阻塞性睡眠呼吸暂停低通气综合征的脑ReHo和ALFF研究．磁共振成像, 2018, 9(9): 648-654. DOI: 10.12015/issn.1674-8034.2018.09.002
[27]
周毅，王琦，张军，等．阻塞性睡眠呼吸暂停低通气综合征患者认知功能障碍的ReHo分析研究．实用放射学杂志, 2018, 34(9): 1321-1324. DOI: 10.3969/j.issn.1002-1671.2018.09.003
[28]
穆新暖，王滨，王晓芝，等．呼吸睡眠暂停低通气患者脑功能的功能性MRI诊断．放射学实践, 2017, 32(1): 16-20. DOI: 10.13609/j.cnki.1000-0313.2017.01.004
[29]
康东杰，鲍海华，秦粽园．阻塞型睡眠呼吸暂停低通气综合征继发红细胞增多症脑静息态fMRI研究．临床放射学杂志, 2019, 38(8): 1366-1370.
[30]
康东杰，鲍海华，秦粽园，等．阻塞型睡眠呼吸暂停低通气综合征脑结构与功能的研究．实用放射学杂志, 2019, 35(1): 6-10. DOI: 10.3969/j.issn.1002-1671.2019.01.002
[31]
Kang D, Qin Z, Wang W, et al. Brain functional changes in tibetan with obstructive sleep apnea hypopnea syndrome: A resting state fMRI study. Medicine (Baltimore), 2020, 99(7): e18957. DOI: 10.1097/MD.0000000000018957
[32]
张莲. OSAHS患者手术前后脑功能局部一致性的静息态功能磁共振研究．东南大学, 2017.
[33]
张慧欣．基于低频振幅的方法评估阻塞性睡眠呼吸暂停低通气综合征患者悬雍垂腭咽成形术后的脑功能改变．东南大学, 2018.
[34]
Chen JE, Glover GH. Functional magnetic resonance imaging methods. Neuropsychol Rev, 2015, 25(3): 289-313. DOI: 10.1007/s11065-015-9294-9
[35]
Buchbinder BR. Functional magnetic resonance imaging. Handb Clin Neurol, 2016, 135: 61-92. DOI: 10.1016/B978-0-444-53485-9.00004-0
[36]
van den Heuvel MP, Hulshoff Pol HE. Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol, 2010, 20(8): 519-534. DOI: 10.1016/j.euroneuro.2010.03.008
[37]
Zhang Q, Qin W, He X, et al. Functional disconnection of the right anterior insula in obstructive sleep apnea. Sleep Med, 2015, 16(9): 1062-1070. DOI: 10.1016/j.sleep.2015.04.018
[38]
Park B, Palomares JA, Woo MA, et al. Aberrant insular functional network integrity in patients with obstructive sleep apnea. Sleep, 2016, 39(5): 989-1000. DOI: 10.5665/sleep.5738
[39]
Song X, Roy B, Kang DW, et al. Altered resting-state hippocampal and caudate functional networks in patients with obstructive sleep apnea. Brain Behav, 2018, 8(6): e00994. DOI: 10.1002/brb3.994
[40]
Yu H, Chen L, Li H, et al. Abnormal resting-state functional connectivity of amygdala subregions in patients with obstructive sleep apnea. Neuropsychiatr Dis Treat, 2019, 15: 977-987. DOI: 10.2147/NDT.S191441
[41]
Park B, Palomares JA, Woo MA, et al. Disrupted functional brain network organization in patients with obstructive sleep apnea. Brain Behav, 2016, 6(3): e00441. DOI: 10.1002/brb3.441
[42]
Calhoun VD, de Lacy N. Ten key observations on the analysis of resting-state functional MR imaging data using independent component analysis. Neuroimaging Clin N Am, 2017, 27(4): 561-579. DOI: 10.1016/j.nic.2017.06.012
[43]
Zhang Q, Wang D, Qin W, et al. Altered resting-state brain activity in obstructive sleep apnea. Sleep, 2013, 36(5): 651-659B. DOI: 10.5665/sleep.2620
[44]
Taylor KS, Kucyi A, Millar PJ, et al. Association between resting-state brain functional connectivity and muscle sympathetic burst incidence. J Neurophysiol, 2016, 115(2): 662-673. DOI: 10.1152/jn.00675.2015
[45]
Chen LT, Fan XL, Li HJ, et al. Aberrant brain functional connectome in patients with obstructive sleep apnea. Neuropsychiatr Dis Treat, 2018, 14: 1059-1070. DOI: 10.2147/NDT.S161085
[46]
Guan WT, Liu B, Huang ZC, et al. Altered regional brain activity of functional connectivity in patients with obstructive sleep apnea. Zhonghua Yi Xue Za Zhi, 2019, 99(14): 1095-1100. DOI: 10.3760/cma.j.issn.0376-2491.2019.14.012
[47]
Chen T, Yang M, Liu B, et al. The resting-state functional connectivity of the default mode networks in patients with obstructive sleep apnea-hypopnea syndrome. CNS Neurol Disord Drug Targets, 2017,16(1): 1-6. DOI: 10.2174/1871527315666161220105021
[48]
Chen LT, Fan XL, Li HJ, et al. Topological reorganization of the default mode network in severe male obstructive sleep apnea. Front Neurol, 2018, 9(363): 1-11. DOI: 10.3389/fneur.2018.00363
[49]
辛会珍，彭德昌，陈立婷，等．阻塞性睡眠呼吸暂停患者前、后默认网络功能连接分离的研究.临床放射志, 2019, 38(8): 1371-1375.
[50]
Mancuso L, Costa T, Nani A, et al. The homotopic connectivity of the functional brain: a meta-analytic approach. Sci Rep, 2019,9(1):3346. DOI: 10.1038/s41598-019-40188-3
[51]
Liu YT, Zhang HX, Li HJ, et al. Aberrant interhemispheric connectivity in obstructive sleep apnea-hypopnea syndrome. Front Neurol, 2018, 9(314): 1-9. DOI: 10.3389/fneur.2018.00314
[52]
Farahani FV, Karwowski W, Lighthall NR. Application of graph theory for identifying connectivity patterns in human brain networks: a systematic review. Front Neurosci, 2019, 13(585): 1-27. DOI: 10.3389/fnins.2019.00585
[53]
Chen LT, Fan XL, Li HJ, et al. Disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI. Neuropsychiatr Dis Treat, 2017, 13: 1471-1482. DOI: 10.2147/NDT.S135426
[54]
Huang Y, Liu Y, Zhao D, et al. Small-world properties of the whole-brain functional networks in patients with obstructive sleep apnea-hypopnea syndrome. Sleep Med, 2019, 62: 53-58. DOI: 10.1016/j.sleep.2018.08.037
[55]
Li HJ, Li L, Shao Y, et al. Abnormal intrinsic functional hubs in severe male obstructive sleep apnea: evidence from a Voxel-wise degree centrality analysis. PLoS One, 2016, 11(10): e0164031. DOI: 10.1371/journal.pone.0164031

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