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• Clinical Article •
Application of 3.0 T MRI 2D-CSI 1H-MRS in children with temporal lobe epilepsy without morphological changes
ZHU Kai  ZENG Lihong  ZHAO Xianglian  ZHANG Xiaofan  WANG Zhiwei  LIU Xinchun  HAO Mingzhu 

Cite this article as: Zhu K, Zeng LH, Zhao XL, et al. Application of 3.0 T MRI 2D-CSI 1H-MRS in children with temporal lobe epilepsy without morphological changes. Chin J Magn Reson Imaging, 2020, 11(12): 1097-1103. DOI:10.12015/issn.1674-8034.2020.12.004.


[Abstract] Objective: To explore the value of two-dimensional chemical shift magnetic resonance imaging of hydrogen proton spectroscopy (2D-CSI 1H-MRS) in the micro changes of hippocampus.Materials and Methods: The spectral data of temporal lobe hippocampus in 36 cases of children and 20 cases of healthy control group were retrospectively analyzed to observe the relationship between gender, age and distribution, and to analyze the metabolic information of MRS in unilateral, bilateral and control groups of observation group and unilateral and healthy side of observation group.Results: There were 36 cases with male and left temporal lobe, but there was no significant difference in gender and location distribution (χ2=1.67, P>0.05); the age of onset of bilateral males in the observation group was younger than that of females (F=12.25, P=0.015). NAA/Cr, NAA/Cho, NAA/(Cho+Cr) in the observation group were significantly lower than those in the control group (F=12.22, 35.786, 6.712; P<0.001), Cho/Cr increased in unilateral group (F=14.712, P<0.001), the differences were statistically significant (P<0.05); compared with the uninjured side, NAA decreased and Cho increased in the observation group (P=0.034, 0.016), and the differences were statistically significant (P<0.05).Conclusions: 2D-CSI 1H-MRS examination showed that there were microscopic abnormalities and changes in cellular and molecular levels in temporal lobe. Therefore, it is a promising tool for the evaluation of TLE in children.
[Keywords] magnetic resonance imaging；two-dimensional chemical shift magnetic resonance imaging of hydrogen proton spectroscopy；morphological changes；temporal lobe epilepsy；children

ZHU Kai* Harbin Children's Hospital, Harbin 150010, China

ZENG Lihong Harbin Children's Hospital, Harbin 150010, China

ZHAO Xianglian Harbin Children's Hospital, Harbin 150010, China

ZHANG Xiaofan Harbin Children's Hospital, Harbin 150010, China

WANG Zhiwei Harbin Children's Hospital, Harbin 150010, China

LIU Xinchun Harbin Children's Hospital, Harbin 150010, China

HAO Mingzhu Harbin Children's Hospital, Harbin 150010, China

*Correspondence to: Zhu K, E-mail: 2008mr-zhukai@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Scientific Research Project of Heilongjiang Provincial Health and Family Planning Commission No. 2017-232
Received  2020-07-08
Accepted  2020-08-21
DOI: 10.12015/issn.1674-8034.2020.12.004
Cite this article as: Zhu K, Zeng LH, Zhao XL, et al. Application of 3.0 T MRI 2D-CSI 1H-MRS in children with temporal lobe epilepsy without morphological changes. Chin J Magn Reson Imaging, 2020, 11(12): 1097-1103. DOI:10.12015/issn.1674-8034.2020.12.004.

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