• Clinical Article •
A Meta analysis of quantitative evaluation of lumbar disc degeneration by diffusion weighted magnetic resonance imaging
Cite this article as: Ma HJ, Zhang XY, POKHAREL SAUGAT, et al. A Meta analysis of quantitative evaluation of lumbar disc degeneration by diffusion weighted magnetic resonance imaging. Chin J Magn Reson Imaging, 2020, 11(12): 1138-1142, 1155. DOI:10.12015/issn.1674-8034.2020.12.012.
| [Abstract] Objective: Based on Meta analysis to explore the clinical application of magnetic resonance diffusion weighted imaging in quantitative evaluation of early lumbar disc degeneration.Materials and Methods: Literature on evaluation of lumbar disc degeneration using diffusion weighted imaging (DWI) published in PubMed, EMBASE, the Cochrane Library, CNKI, Wanfang and VIPS databases from the self-built database to October 1, 2019 was retrieved. Two researchers independently screened and extracted the retrieved literature according to inclusion and exclusion criteria. Combie cross study evaluation tool was used to evaluate the quality of the included literature. Using RevMan 5.3 and Stata 15.0 software for Meta analysis.Results: A total of 12 references were included. There were 577 grade Ⅰ discs, 1704 grade Ⅱ discs, 1299 grade Ⅲ discs, 1092 grade Ⅳ discs and 194 grade Ⅴ discs. ADC value of grade Ⅰ discs nucleus pulposus was higher than that of grade Ⅱ discs nucleus pulposus. The difference was statistically significant weighted mean difference (WMD)=0.034, 95% CI: 0.005—0.064, P=0.024. ADC value of grade Ⅱ discs nucleus pulposus was significantly higher than that of grade Ⅲ discs nucleus pulposus (WMD=0.161, 95% CI: 0.124—0.197, P<0.0001). ADC value of grade Ⅲ discs nucleus pulposus was significantly higher than that of grade Ⅳ discs nucleus pulposus (WMD=0.297, 95% CI: 0.222—0.373, P<0.0001). ADC value of grade Ⅳ discs nucleus pulposus was significantly higher than that of grade Ⅴ discs nucleus pulposus (WMD=0.293, 95% CI: 0.176—0.411, P<0.0001).Conclusions: Diffusional weighted imaging can quantitatively evaluate different grades of lumbar disc degeneration, especially distinguish early lumbar disc degeneration, and provide imaging basis for early diagnosis of lumbar disc degeneration. |
| [Keywords] diffusion weighted imaging；magnetic resonance imaging；apparent diffusion coefficient；lumbar disc degeneration；Meta analysis |
MA Hongju Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China; Department of Imaging, Xixiang County People’s Hospital of Shaanxi Province, Hanzhong 723500, China
ZHANG Xuyin Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
SAUGAT POKHAREL Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
GUO Yinxia Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
DU Yonghao Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
WANG Rong Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
NIU Gang* Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
*Correspondence to: Niu G, E-mail: niugang369@xjtu.edu.cn
Conflicts of interest None.
| ACKNOWLEDGMENTS This work was part of Key Research and Development Program of Shaanxi No. 2020SF-104 |
| Received 2020-06-11 |
| Accepted 2020-08-21 |
| DOI: 10.12015/issn.1674-8034.2020.12.012 |
| Cite this article as: Ma HJ, Zhang XY, POKHAREL SAUGAT, et al. A Meta analysis of quantitative evaluation of lumbar disc degeneration by diffusion weighted magnetic resonance imaging. Chin J Magn Reson Imaging, 2020, 11(12): 1138-1142, 1155. DOI:10.12015/issn.1674-8034.2020.12.012. |
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