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• Clinical Article •
MRI findings of whole spinal in 22 patients with SAPHO syndrome
YU Meiyan  TANG Ying  LIU Junlian  ZHANG Ya’nan  HUANG Ziwei  HUO Jianwei  LI Chen  SUN Boyuan  ZHANG Wen  LI Junqiu 

Cite this article as: Yu MY, Tang Y, Liu JL, et al. MRI findings of whole spinal in 22 patients with SAPHO syndrome. Chin J Magn Reson Imaging, 2020, 11(12): 1143-1147. DOI:10.12015/issn.1674-8034.2020.12.013.


[Abstract] Objective: To evaluate MRI manifestations of the whole spinal lesions of synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis (SAPHO) syndrome and investigate its regularity.Materials and Methods: The distribution, involvement patterns, and characteristics of both active inflammatory and chronic structural lesions of the whole spine 3.0 T MRI images of 22 SAPHO syndrome patients were analyzed. Auto-tracking-bedscanning technic was applied to scan the cervical, thoracic, and lumbar part and the image was stitched by whole spine imaging software.Results: SAPHO syndrome involvement spinal lesions were mainly located in the thoracic segments (45.4% of spinal lesions) (P<0.05). Bone marrow edema (BME) was the most common active lesion, and lipid deposition was the most common structural lesion, which were mainly distributed at the anterior corners of thoracic vertebra. The jump distribution and parallel distribution were 53.3% and 46.7% of BME, 41.3% and 58.7% of lipid deposition, respectively. Other lesions included bone bridge (3.9%), bone erosion (19.2%), osteosclerosis (3.0%), narrowing of intervertebral space (4.3%), compression fractures (3.5%), involvement of the paravertebral soft tissue (4.6%).Conclusions: The whole spinal lesions of SAPHO syndrome is characterized by BME and lipid deposition at the anterior corners of thoracic vertebra, which are distributed in jump and parallel manners. These characteristics may be diagnostic clue for SAPHO syndrome.
[Keywords] SAPHO syndrome；spine；magnetic resonance imaging；case report

YU Meiyan Department of Radiology, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, China

TANG Ying School of Traditional Chinese Medicine, Beijing University of Traditional Chinese Medicine, Beijing 100029, China

LIU Junlian Department of Radiology, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, China

ZHANG Ya’nan Department of Radiology, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, China

HUANG Ziwei School of Traditional Chinese Medicine, Beijing University of Traditional Chinese Medicine, Beijing 100029, China

HUO Jianwei Department of Radiology, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, China

LI Chen Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China

SUN Boyuan Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

ZHANG Wen Department of Rheumatology and Immunology, Peking Union Medical College Hospital, Beijing 100005, China

LI Junqiu* Department of Radiology, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, China

*Correspondence to: Li JQ, E-mail: junqiu29@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of CAMS Innovation Fund for Medical Sciences (CIFMS) No.2017-I2M-3-001
Received  2020-08-02
Accepted  2020-11-14
DOI: 10.12015/issn.1674-8034.2020.12.013
Cite this article as: Yu MY, Tang Y, Liu JL, et al. MRI findings of whole spinal in 22 patients with SAPHO syndrome. Chin J Magn Reson Imaging, 2020, 11(12): 1143-1147. DOI:10.12015/issn.1674-8034.2020.12.013.

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