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• Health for all, Prosperity for all •
Application of MRI 3D-pCASL in patients with acute cerebral infarction
ZHAO Wenchao  SONG Yu  TANG Chenhu  WU Xue  MA Dong  JIANG Yilun 

Cite this article as: Zhao WC, Song Y, Tang CH, et al. Application of MRI 3D-pCASL in patients with acute cerebral infarction. Chin J Magn Reson Imaging, 2020, 11(12): 1156-1158, 1166. DOI:10.12015/issn.1674-8034.2020.12.016.


[Abstract] Objective: To investigate the clinical value of three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) in patients with acute cerebral infarction.Materials and Methods: A total of 84 patients with acute cerebral infarction (cerebral infarction group) were selected. The cerebral infarction group was divided into a hemorrhagic transformation group (35 cases) and a non-hemorrhagic transformation group (49 cases) according to the presence or absence of hemorrhagic transformation after thrombolysis. And 50 healthy volunteers were selected as the control group. All patients were examined by MRI 3D-pCASL, and statistical analysis was performed.Results: MRI of cerebral infarction patients showed large cerebral hemisphere hypoperfusion regions, while no distal vascular branches were shown. DWI showed significantly high signals, and ADC images showed significantly low signals. In 54 patients with cerebral infarction, the lesion was located in the right cerebral hemisphere, while in 30 patients with cerebral infarction. the absolute value of rCBF and ADC value in the core area of cerebral infarction were lower than those in the contralateral mirror area; the absolute value of rCBF and ADC value in both sides were lower than those in the healthy control group (P<0.05). ROC curve analysis was carried out with 3D-pCASL image post-processing parameter rCBF, and the area under ROC was 0.915. The absolute value of peripheral blood flow (rCBF) and ADC values in the cerebral infarction core area of patients in the hemorrhagic transformation group were higher than those in the non-hemorrhagic transformation group (P<0.05). ROC curve analysis was carried out with 3D-pCASL image post-processing parameter rCBF, and the area under ROC was 0.926.Conclusions: 3D-pCASL can display the hemodynamic state information of infarction lesions in patients with acute cerebral infarction. Combined with rCBF. It can objectively reflect the changes of cerebral ischemic infarction perfusion, and has certain value in predicting hemorrhage transformation after treatment, providing imaging basis for clinical diagnosis.
[Keywords] magnetic resonance imaging；three-dimensional pseudo-continuous arterial spin labeling；stroke；transient ischemic attack；diffusion weighted imaging

ZHAO Wenchao Department of Radiology, Nanjing Integrated Traditional Chinese and Western medicine Hospital, Nanjing 210014, China

SONG Yu Department of Ultrasound, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing 210014, China

TANG Chenhu Department of Radiology, Nanjing Integrated Traditional Chinese and Western medicine Hospital, Nanjing 210014, China

WU Xue Department of Radiology, Nanjing Integrated Traditional Chinese and Western medicine Hospital, Nanjing 210014, China

MA Dong* Department of Radiology, Nanjing Integrated Traditional Chinese and Western medicine Hospital, Nanjing 210014, China

JIANG Yilun Department of Neurology, Wuxi Xishan People's Hospital, Wuxi 214000, China

*Correspondence to: Ma D, E-mail: mdwllmht@163.com

Conflicts of interest   None.

Received  2020-08-21
Accepted  2020-12-03
DOI: 10.12015/issn.1674-8034.2020.12.016
Cite this article as: Zhao WC, Song Y, Tang CH, et al. Application of MRI 3D-pCASL in patients with acute cerebral infarction. Chin J Magn Reson Imaging, 2020, 11(12): 1156-1158, 1166. DOI:10.12015/issn.1674-8034.2020.12.016.

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