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The differential diagnosis of benign and malignant breast tumors with MRI quantitative and semi-quantitative parameters and the correlation analysis with biological indicators of breast cancer
WANG Mingfu  XU Wei  QIN Tao 

Cite this article as: Wang MF, Xu W, Qin T. The differential diagnosis of benign and malignant breast tumors with MRI quantitative and semi-quantitative parameters and the correlation analysis with biological indicators of breast cancer. Chin J Magn Reson Imaging, 2020, 11(12): 1174-1177. DOI:10.12015/issn.1674-8034.2020.12.021.


[Abstract] Objective: To investigate the differential diagnosis of MRI diffusion weighted imaging (DWI) and semi-quantitative dynamic contrast-enhanced (DCE) parameters for benign and malignant breast tumors and their correlation with the biological parameters of breast cancer.Materials and Methods: The clinical datas of 50 patients with breast tumor in our hospital were retrospectively analyzed. According to the pathological results after surgical resection, they were divided into the breast cancer group (31 cases) and the benign tumor group (19 cases). Immunohistochemical examination was performed on all the breast cancer patients, and they were further divided into the PR, ER and HER-2 positive groups and the progesterone receptor (PR), estrogen receptor (ER) and human epithelial factor receptor-2 (HER-2) negative groups. All patients were examined by DWI and DCE. The apparent diffusion coefficient (ADC) and the peak time (Tmax), the early enhancement rate (EER) and the peak enhancement rate (Emax) of DCE were measured. Immunohistochemistry was used to detect the biological indicators of breast cancer, such as cell proliferation antigen markers Ki-67, PR, ER and HER-2. The differences of MR quantitative parameters and semi-quantitative parameters in benign and malignant breast tumors were compared, and the correlation between these parameters and biological indicators of breast cancer was analyzed.Results: The EER in the breast cancer group was higher than that in the benign tumor group (P<0.05), while ADC, Tmax and Emax values were all lower than that in the benign tumor group (P<0.05). There was no difference in ADC values between the positive group and the negative group (P>0.05). The Tmax and Emax values of the positive breast cancer PR, ER and HER-2 groups were all lower than those of the negative group (P values were all less than 0.05). EER was significantly higher in the positive group of PR, ER and HER-2 than in the negative group (P<0.05). EER was positively correlated with Ki-67 expression (r=0.49, P<0.01). ADC, Tmax and Emax values were negatively correlated with Ki-67 expression (r=-0.52, -0.45 and -0.43, all P values were less than 0.05).Conclusions: DWI quantitative parameters and DCE semi-quantitative parameters can not only be used in the differential diagnosis of benign and malignant breast tumors, but also can be used as the prediction index of biological behavior of breast cancer, which provide information for clinicians to treate.
[Keywords] magnetic resonance imaging；breast tumor；differential diagnosis；prognostic factor；diffusion weighted imaging；dynamic contrast-enhanced

WANG Mingfu Department of Radiology, the Third People’s Hospital of Hubei Province, Wuhan 430033, China

XU Wei Department of Radiology, the Third People’s Hospital of Hubei Province, Wuhan 430033, China

QIN Tao* Department of Radiology, the Third People’s Hospital of Hubei Province, Wuhan 430033, China

*Correspondence to: Qin T, E-mail: qyypiano@163.com

Conflicts of interest   None.

Received  2020-08-25
Accepted  2020-11-21
DOI: 10.12015/issn.1674-8034.2020.12.021
Cite this article as: Wang MF, Xu W, Qin T. The differential diagnosis of benign and malignant breast tumors with MRI quantitative and semi-quantitative parameters and the correlation analysis with biological indicators of breast cancer. Chin J Magn Reson Imaging, 2020, 11(12): 1174-1177. DOI:10.12015/issn.1674-8034.2020.12.021.

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