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• CLINICAL ARTICLE •
A multimodal magnetic resonance study of the effects of acute alcohol on CBF and OEF in memory-related brain regions in young people
SANG Fei  CHEN Jun  AO Yawen  ZHANG Liang  NIE Hongyan 

Cite this article as: Sang F, Chen J, Ao YW, et al. A multimodal magnetic resonance study of the effects of acute alcohol on CBF and OEF in memory-related brain regions in young people[J]. Chin J Magn Reson Imaging, 2021, 12(1): 27-32. DOI:10.12015/issn.1674-8034.2021.01.006.


[Abstract] Objective Three-dimensional pseudo-continuous arterial spin labeling (3D pCASL) and asymmetric spine echo-based echo plane imaging (ASE EPI) were used to study the effects of different doses of acute alcohol on cerebral blood flow (CBF) and oxygen extraction fraction (OEF) in the memory-related brain regions of healthy young people, and to analyze the relationship between CBF and OEF in memory-related brain regions after different doses of acute alcohol consumption.Materials and Methods Twenty-nine young volunteers were fed with different doses of Chinese alcohol. After drinking, blood alcohol concentration (BAC) was measured. BAC≥0.04% was the low concentration group, BAC≥0.06% was the medium concentration group, and BAC≥0.08% was the high concentration group, respectively. All subjects were examined by the memory function test and brain MRI before drinking and 30 minutes after drinking. The data before drinking was as the control group. The values of CBF and OEF in left middle frontal gyrus, parietal lobe, occipital cortex, bilateral cingulate gyrus, hippocampus, amygdala and bilateral cerebellar hemisphere were compared before and after drinking respectively.Results (1) Compared with pre-drinking, 30 minutes after drinking, the CBF of left middle frontal gyrus, parietal lobe, occipital cortex, bilateral cingulate gyrus, hippocampus, amygdala increased (P＜0.05), and the CBF of bilateral cerebellar hemisphere decreased (P＜0.05). The difference of CBF within mild, moderate and severe dose groups was statistically significant (P＜0.05) by multiple comparison of LSD-t test. (2) Compared with pre-drinking, 30 minutes after drinking, the OEF of left middle frontal gyrus, parietal lobe, occipital cortex, bilateral cingulate gyrus, hippocampus, amygdala decreased (P＜0.05), and the OEF of bilateral cerebellar hemisphere increased (P＜0.05). The difference of OEF within mild, moderate and severe dose groups was statistically significant (P＜0.05) by multiple comparison of LSD-t test.Conclusions After acute alcohol, the CBF and OEF of the memory-related brain regions showed a negative correlation, and the brain oxygen supply and utilization were in dynamic balance. The changes of cerebral blood flow and cerebral metabolism information of memory-related brain regions after acute alcohol have certain significance in revealing the mechanism of alcohol on the memory-related brain regions.
[Keywords] acute alcohol；memory；three-dimensional pseudo-continuous arterial spin labeling；asymmetric echo-based echo plane imaging；functional magnetic resonance imaging

SANG Fei1, 2   CHEN Jun2*   AO Yawen2   ZHANG Liang2   NIE Hongyan3  

1 Department of Radiology, Peking University Shenzhen Hospital, Shenzhen 518035, China

2 Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

3 Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

*Corresponding author: Chen J, E-mail: whuchenjun@163.com

Conflicts of interest   None.

Received  2020-06-23
Accepted  2020-11-20
DOI: 10.12015/issn.1674-8034.2021.01.006
Cite this article as: Sang F, Chen J, Ao YW, et al. A multimodal magnetic resonance study of the effects of acute alcohol on CBF and OEF in memory-related brain regions in young people[J]. Chin J Magn Reson Imaging, 2021, 12(1): 27-32. DOI:10.12015/issn.1674-8034.2021.01.006.

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