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• CLINICAL ARTICLE •
Intravoxel incoherent motion magnetic resonance imaging detecting alterations on optic nerve in the patients with orbital tumor
ZHANG Xueping  BAI Yan  WANG Meiyun  CHEN Chuanliang 

Cite this article as: Zhang XP, Bai Y, Wang MY, et al. Intravoxel incoherent motion magnetic resonance imaging detecting alterations on optic nerve in the patients with orbital tumor[J]. Chin J Magn Reson Imaging, 2021, 12(1): 33-37. DOI:10.12015/issn.1674-8034.2021.01.007.


[Abstract] Objective To investigate the value of intravoxel incoherent motion (IVIM) magnetic resonance imaging in evaluating the degree of optic nerve injury in orbital tumors.Materials and Methods Twenty-five patients with space-occupying lesions confirmed by imaging examination and 12 volunteers were enrolled in this study, the difference of apparent diffusion coefficient (ADC), slow ADC (D), fast ADC (D*), fractional of fast ADC (f) of the affected side optic nerve and the contralateral side were compared by paired t test, parameters and the asymmetry index (AI) of parameters of optic nerve between the patient group and the control group were compared by independent sample t-test. International standard visual acuity chart was used to measure visual acuity, 11 cases were impaired visual acuity, 14 cases were not.Results The affected side optic nerve presented significantly decreased f compared to the unaffected side [f=(28.2±2.7)%, (46.4±3.0)% respectively; P=0.0015], the affected side optic nerve presented significantly decreased f compared to the control group [f=(28.2±2.7)%, (45.4±5.5)% respectively; P=0.002], the visual impaired patients presented significantly decreased D* compared to the not visual impared [D*=(26.6±7.0)×10－3 mm2/s, (62.5±11.0)×10－3 mm2/s respectively; P=0.023]; affected group optic nerve presented significantly increased AI of f compared to the control group (AI of f =0.26±0.06, 0.03±0.06 respectively; P=0.033); there was a low correlation between visual acuity and D* of affected optic nerve(r=0.462, P=0.02).Conclusions The voxel incoherent motion parameter D* was superior to the conventional single-exponential ADC in evaluating the optic nerve function damage caused by orbital tumors, and can provide more abundant information.
[Keywords] magnetic resonance imaging；intravoxel incoherent motion；optic nerve；orbit；tumor

ZHANG Xueping   BAI Yan   WANG Meiyun   CHEN Chuanliang*  

Zhengzhou University People's Hospital,Henan Provincial People's HospitalDepartment of imaging, Zhengzhou University people's Hospital, Henan Provincial People's hospital, Zhengzhou 450003, China

*Corresponding author: Chen CL, E-mail: henanccl@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Supported by the National Key Research and Development Program of China No. 2017YFE0103600 National Natural Science Foundation of China No.81601466
Received  2020-09-22
Accepted  2020-11-30
DOI: 10.12015/issn.1674-8034.2021.01.007
Cite this article as: Zhang XP, Bai Y, Wang MY, et al. Intravoxel incoherent motion magnetic resonance imaging detecting alterations on optic nerve in the patients with orbital tumor[J]. Chin J Magn Reson Imaging, 2021, 12(1): 33-37. DOI:10.12015/issn.1674-8034.2021.01.007.

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