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• CLINICAL ARTICLE •
Probe of the central mechanism of analgesic effect of ozone water on patients with knee osteoarthritis pain based on rs-fMRI technique
TIAN Mingyue  CHEN Yunjie  DING Xiaofen  ZHANG Ruya  SONG Qiaoyan  HAN Songchen  ZHOU Youlong 

Cite this article as: Tian MY, Chen YJ, Ding XF, et al. Probe of the central mechanism of analgesic effect of ozone water on patients with knee osteoarthritis pain based on rs-fMRI technique[J]. Chin J Magn Reson Imaging, 2021, 12(1): 53-58. DOI:10.12015/issn.1674-8034.2021.01.011.


[Abstract] Objective To explore the central mechanism of analgesic effect of ozone water on knee osteoarthritis (KOA) patients with chronic pain by resting state functional magnetic resonance imaging (rs-fMRI), so as to provide theoretical basis for ozone water treatment of KOA.Materials and Methods Eighteen patients with KOA who met the inclusion criteria were treated with joint cavity irrigation with ozone water. Visual analogue score (VAS) and rs-fMRI scan were performed before and after ozone water treatment. Regional homogeneity (ReHo) t data analysis method was used to analyze the brain areas with significant changes in ReHo after ozone water treatment. Pearson correlation analysis was performed between the changed ReHo and the changed VAS score.Results After treatment with ozone water, ReHo values in different brain regions such as middle occipital gyrus, superior occipital gyrus, cuneiform lobe and angular gyrus in KOA patients increased, while ReHo values in superior temporal gyrus, central sulcus cover and precentral gyrus decreased. The results of correlation analysis showed that there was a negative correlation between the changes of ReHo and VAS in the right insular after ozone water treatment.Conclusions Ozone water therapy may treat pain in patients with KOA by regulating the function of temporal lobe, parietal lobe, frontal lobe and occipital lobe, while insular may be the critical brain area of ozone water analgesia.
[Keywords] ozone water；functional magnetic resonance imaging；local consistency；knee osteoarthritis；analgesia

TIAN Mingyue1   CHEN Yunjie1   DING Xiaofen1   ZHANG Ruya1   SONG Qiaoyan1   HAN Songchen1   ZHOU Youlong2*  

1 Colloge of Acupuncture and Massage, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China

2 Colloge of International Education, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China

*Corresponding author: Zhou YL, E-mail: youlong666@163.com

Conflicts of interest   None.

Received  2020-09-24
Accepted  2020-11-30
DOI: 10.12015/issn.1674-8034.2021.01.011
Cite this article as: Tian MY, Chen YJ, Ding XF, et al. Probe of the central mechanism of analgesic effect of ozone water on patients with knee osteoarthritis pain based on rs-fMRI technique[J]. Chin J Magn Reson Imaging, 2021, 12(1): 53-58. DOI:10.12015/issn.1674-8034.2021.01.011.

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