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The pathogenesis of iron and oxidative stress in multiple sclerosis and advances in MRI
CHEN Qianlan  YE Haiqi  CHEN Weiwei 

Cite this article as: Chen QL, Ye HQ, Chen WW. The pathogenesis of iron and oxidative stress in multiple sclerosis and advances in MRI[J]. Chin J Magn Reson Imaging, 2021, 12(1): 89-92. DOI:10.12015/issn.1674-8034.2021.01.020.


[Abstract] Multiple sclerosis (MS) is the most common inflammatory demyelinating disease in the central nervous system, and its pathogenesis is still unknown. In recent years, studies have shown that iron and oxidative stress are involved in the pathogenesis of MS, but the specific temporal and spatial dynamic changes have not been fully clarified. Therefore, the non-invasive quantitative evaluation of iron and oxidative stress in MS lesions with multi-parameter MRI is of great significance to reveal the different pathological characteristics of MS in different stages. This article reviews the potential pathogenic mechanism of iron and oxidative stress in multiple sclerosis and the corresponding research progress of MRI.
[Keywords] multiple sclerosis；oxidative stress；iron deposition；magnetic resonance imaging

CHEN Qianlan   YE Haiqi   CHEN Weiwei*  

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

*Corresponding author: Chen WW, E-mail: chenweiwei_tjh@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the National Natural Science Found No. 81401390
Received  2020-08-08
Accepted  2020-11-20
DOI: 10.12015/issn.1674-8034.2021.01.020
Cite this article as: Chen QL, Ye HQ, Chen WW. The pathogenesis of iron and oxidative stress in multiple sclerosis and advances in MRI[J]. Chin J Magn Reson Imaging, 2021, 12(1): 89-92. DOI:10.12015/issn.1674-8034.2021.01.020.

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