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• CLINICAL ARTICLE •
Study of amplitude of low-frequency fluctuations and brain functional connectivity in patients with end-stage renal disease of Uygur population in Southern of Xinjiang
TIAN Xuwei  ESKELJIANG·Hojia   ADILJIANG·Ablet   ZOU Ke  WU Xiaoyan 

Cite this article as: Tian XW, Eskeljiang·H , Adiljiang·A, et al. Study of amplitude of low-frequency fluctuations and brain functional connectivity in patients with end-stage renal disease of Uygur population in Southern of Xinjiang[J]. Chin J Magn Reson Imaging, 2021, 12(2): 43-48. DOI:10.12015/issn.1674-8034.2021.02.010.


[Abstract] Objective To investigate the characteristics of amplitude of low frequency fluctuation (ALFF) and brain functional connectivity (FC) in patients with end-stage renal disease (ESRD) in southern of Xinjiang Uyghur autonomous region by using resting-state functional MRI (rs-fMRI). Materials andMethods Rs-fMRI examinations were performed in 15 Uyghur patients with ESRD and 20 gender-, age- and education-matched healthy Uyghurs who were long-term residents of the same area. The Montreal Cognitive Assessment (MoCA) Scale was used to test the cognitive ability of the ESRD patients. The ALFF and seed-based FC were computed and compared between ESRD patients and healthy controls. The relationships between the altered ALFF or FC and clinical indicators were further assessed in Uyghur ESRD patients by using the Pearson correlation.Results Compared with control group, ESRD group showed decreased ALFF (spontaneous activity) in the bilateral precuneus (peak location: right precuneus). Seed-based FC analysis showed the FC between right precuneus and the right precuneus, bilateral middle cingulate, bilateral posterior cingulate, right medial orbitofrontal cortex in ESRD group were lower than those of the control group. In the ESRD group, Pearson correlation analysis revealed that the FC between right precuneus and right medial orbitofrontal was positively correlated with the MoCA score (r=0.683, P=0.005).Conclusions The decreased spontaneous activity and functional connectivity in the default mode network in the Uyghur ESRD may cause brain function impairment and cognitive deficit.
[Keywords] end-stage renal disease；resting state functional magnetic resonance imaging；amplitude of low frequency fluctuation；functional connectivity；brain network

TIAN Xuwei1   ESKELJIANG·Hojia 1   ADILJIANG·Ablet 1   ZOU Ke1   WU Xiaoyan2*  

1 Deparement of Radiology, Kashgar First People's Hospital, Kashgar 844000, China

2 Deparement of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

Wu XY, E-mail: wuxy226@mail.sysu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS This work was part of Tianshan Youth Program of Xinjiang Uygur Autonomous Region-Outstanding Young Scientific and Technological Talents (No.2018Q056); Autonomous Region Health Youth Medical Science and Technology Talents Project (No.WJWY201942).
Received  2020-10-31
Accepted  2021-01-12
DOI: 10.12015/issn.1674-8034.2021.02.010
Cite this article as: Tian XW, Eskeljiang·H , Adiljiang·A, et al. Study of amplitude of low-frequency fluctuations and brain functional connectivity in patients with end-stage renal disease of Uygur population in Southern of Xinjiang[J]. Chin J Magn Reson Imaging, 2021, 12(2): 43-48. DOI:10.12015/issn.1674-8034.2021.02.010.

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