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Application and development of MRI in obstructive sleep apnea hypopnea syndrome
LI Yunxia  PENG Kun 

Cite this article as: Li YX, Peng K. Application and development of MRI in obstructive sleep apnea hypopnea syndrome[J]. Chin J Magn Reson Imaging, 2021, 12(2): 101-104. DOI:10.12015/issn.1674-8034.2021.02.025.


[Abstract] Obstructive sleep apnea hypopnea syndrome is a common sleep disorder. Intermittent breathing during sleep will cause frequent hypoxia and severe sleep disruption, leading to structural, metabolic and functional abnormalities in several brain regions, leading to neurocognitive deficits. Because of the advantages of multi-sequence imaging and various imaging techniques, magnetic resonance imaging has a very good advantage in explaining the changes of central nervous system, and provides an objective imaging basis for clinical understanding of the pathogenesis and cognitive dysfunction of obstructive sleep apnea hypopnea syndrome.
[Keywords] obstructive sleep apnea hypopnea syndrome；magnetic resonance imaging；brain structure；cognitive function

LI Yunxia1   PENG Kun2*  

1 School of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China

2 Department of Magnetic Resonance, General Hospital of Taiyuan Iron & Steel (Group) Co., LTD., Taiyuan 030008, China

Peng K, E-mail: pengkun-962010@126.com

Conflicts of interest   None.

Received  2020-09-28
Accepted  2021-01-12
DOI: 10.12015/issn.1674-8034.2021.02.025
Cite this article as: Li YX, Peng K. Application and development of MRI in obstructive sleep apnea hypopnea syndrome[J]. Chin J Magn Reson Imaging, 2021, 12(2): 101-104. DOI:10.12015/issn.1674-8034.2021.02.025.

1
Epstein LJ, Kristo D, Strollo PJ, et al. Clinical guideline for the eval-uation, management and long-term care of obstructive sleep apnea in adults[J]. J Clin Sleep Med, 2009, 5(3): 263-276.
2
Sleep respiratory diseases group of respiratory medicine branch of Chinese Medical Association. Guidelines for the diagnosis and treatment of obstructive sleep apnea-hypopnea syndrome (2011 revised edition)[J]. Chin J Tuberc Respir Dis, 2012, 35(1): 9-12. DOI: 10.3760/cma.j.issn.1001-0939.2012.01.007.
3
Peppard PE, Young T, Barnet JH, et al. Increased prevalence of sleep-disordered breathing in adults[J]. Am J Epidemiol, 2013, 177(9): 1006-1014. DOI: 10.1093/aje/kws342.
4
Semelka M, Wilson J, Floyd R. Diagnosis and treatment of obstructive sleep apnea in adults[J]. Am Fam Physician, 2016, 94(5): 355-360.
5
Kendzerska T, Mollayeva T, Gershon AS, et al. Untreated obstructive sleep apnea and the risk for serious long-term adverse outcomes: A systematic review[J]. Sleep Med Rev, 2014, 18(1): 49-59. DOI: 10.1016/j.smrv.2013.01.003.
6
Liu GQ, Ouyang RY. Research progress of resting state functional magnetic res-onance imaging in evaluating cognitive function of patients with obstructive sl-eep apnea[J]. J Cent South Univ (Med Sci), 2019, 44(5): 515-521. DOI: 10.11817/j.issn.1672-7347.2019.05.007.
7
Wei K, Guo SQ, Wen WS. Research progress on the relationship between obstr-uctive sleep disordered breathing and systemic multisystem diseases[J]. Chin J Geriatr Dent, 2016, 14(1): 54-57. DOI: 10.3969/j.issn.1672-2973.2016.01.014.
8
Ho BL, Tseng PT, Lai CL, et al. Obstructive sleep apnea and cerebral white ma-tter change: a systematic review and meta-analysis[J]. J Neurol, 2018, 265(7): 1643-1653. DOI: 10.1007/s00415-018-8895-7.
9
Kim H, Yun CH, Thomas RJ, et al. Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population[J]. Sleep, 2013, 36(5): 709-715. DOI: 10.5665/sleep.2632.
10
de Groot M, Verhaaren BF, de Boer R, et al. Changes in normal-appearing white matter precede development of white matter lesions[J]. Stroke, 2013, 44(4): 1037-1042. DOI: 10.1161/STROKEAHA.112.680223.
11
Kumar R, Pham TT, Macey PM, et al. Abnormal myelin and axonal integrity i-n recently diagnosed patients with obstructive sleep apnea[J]. Sleep, 2014, 37(4): 723-732. DOI: 10.5665/sleep.3578.
12
Cao QQ, Niu CH, Qi JC, et al. A study on the damage of myelin and axon in patients with obstructive sleep apnea hypopnea syndrome[J]. J Hebei Med Univ, 2016, 37(4): 422-426, 497. DOI: 10.3969/j.issn.1007-3205.2016.04.013.
13
Qin F, Jin J, Zou LW, et al. A study on white matter damage in patients with moderate to severe obstructive sleep apnea-hypopnea syndrome[J]. Radiol Pract, 2018, 33(7): 668-673. DOI: 10.13609/j.cnki.1000-0313.2018.07.003.
14
Kumar R, Chavez AS, Macey PM, et al. Altered global and regional brain mean diffusivity in patients with obstructive sleep apnea[J]. J Neurosci Res, 2012, 90(10): 2043-2052. DOI: 10.1002/jnr.23083.
15
Zhang B, Zhu DM, Zhao W, et al. Selective microstructural integrity impairments of the anterior corpus callosum are associated with cognitive deficits in obstructive sleep apnea[J]. Brain Behav, 2019, 9(12): e01482. DOI: 10.1002/brb3.1482.
16
Maresky HS, Shpirer I, Klar MM, et al. Continuous positive airway pressure alters brain microstructure and perfusion patterns in patients with obstructive sleep apnea[J]. Sleep Med, 2019, 57: 61-69. DOI: 10.1016/j.sleep.2018.12.027.
17
Castronovo V, Scifo P, Castellano A, et al. White matter integrity in obstructive sleep apnea before and after reatment[J]. Sleep, 2014, 37(9): 1465-1475. DOI: 10.5665/sleep.3994.
18
Xiong Y, Zhou XJ, Nisi RA, et al. Brain white matter changes in CPAP-treated obstructive sleep apnea patients with residual sleepiness[J]. J Magn Reson Imaging, 2017, 45(5): 1371-1378. DOI: 10.1002/jmri.25463.
19
Yadav SK, Kumar R, Macey PM, et al. Regional cerebral blood flow alterations in obstructive sleep apnea[J]. Neurosci Lett, 2013, 555: 159-164. DOI: 10.1016/j.neu-let.2013.09.033.
20
Mao XF. MRI study of brain changes in patients with severe obstructive sleep apnea syndrome[D]. Suzhou: Suzhou University, 2017: 1-116.
21
Nie S, Peng DC, Gong HH, et al. Resting cerebral blood flow alteration in severe obstructive sleep apnoea: an arterial spin labelling perfusion fMRI study[J]. Sleep Breath, 2017, 21(2): 487-495. DOI: 10.1007/s11325-017-1474-9.
22
Chen HL, Lin HC, Lu CH, et al. Systemic inflammation and alterations to cere-bral blood flow in obstructive sleep apnea[J]. J Sleep Res, 2017, 26(6): 789-798. DOI: 10.1111/jsr.12553.
23
Steven AJ, Zhuo J, Melhem ER. Diffusion kurtosis imaging: an emerging technique for evaluating the microstructural environment of the brain[J]. AJR Am J Roentgenol, 2014, 202(1): W26-33. DOI: 10.2214/AJR.13.11365.
24
Vyas S, Singh P, Khandelwal N, et al. Evaluation of cerebral microstructural c-hanges in adult patients with obstructive sleep apnea by MR diffusion kurtosis imaging using a whole-brain atlas[J]. Indian J Radiol Imaging, 2019, 29(4): 356-363. DOI: 10.4103/ijri.IJRI_326_19.
25
Li WF, Wen HW, Liu Y, et al. A study on brain microstructural changes of children with obstructive sleep apnea syndrome by diffusion kurtosis imaging[J]. J Capit Univ Med Sci, 2018, 33(2): 178-184. DOI: 10.3969/j.iSSN.1006-7795.2018.02.005.
26
Tummala S, Palomares J, Kang DW, et al. Global and regional brain non-gaussian diffusion changes in newly diagnosed patients with obstructive sleep apnea[J]. Sleep, 2016, 39(1): 51-57. DOI: 10.5665/sleep.5316.
27
Tummala S, Roy B, Vig R, et al. Non-gaussian diffusion imaging shows brain myelin and axonal changes in obstructive sleep apnea[J]. J Comput Assist Tomogr, 2017, 41(2): 181-189. DOI: 10.1097/RCT.0000000000000537.
28
Qin JB. The application of voxel-based morphometry in cognitive dysfunction[J]. J Southeast Univ(Med Sci Edi), 2010, 29(4): 477-480. DOI: 10.3969/j.issn.1671-6264.2010.04.033.
29
Morrell MJ, Jackson ML, Twigg GL, et al. Changes in brain morphology in pa-tients with obstructive sleep apnoea[J]. Thorax, 2010, 65(10): 908-914. DOI: 10.1136/thx.2009.126730.
30
Shi Y, Chen L, Chen T, et al. A meta-analysis of voxel-based brain morphometry studies in obstructive sleep apnea[J]. Sci Rep, 2017, 7(1): 10095. DOI: 10.1038/s41598-017-09319-6.
31
Yeung AWK. Morphometric and functional connectivity changes in the brain of patients with obstructive sleep apnea: A meta-analysis[J]. J Sleep Res, 2019, 28(6): e12857. DOI: 10.1111/jsr.12857.
32
Baril AA, Gagnon K, Brayet P, et al. Gray matter hypertrophy and thickening with obstructive sleep apnea in middle-aged and older adults[J]. Am J Respir Crit Care Med, 2017, 195(11): 1509-1518. DOI: 10.1164/rccm.201606-1271OC.
33
Joo EY, Tae WS, Lee MJ, et al. Reduced brain gray matter concentration in patients with obstructive sleep apnea syndrome[J]. Sleep, 2010, 33(2): 235-241.
34
O'Donoghue FJ, Briellmann RS, Rochford PD, et al. Cerebral structural changes in severe obstructive sleep apnea[J]. Am J Respir Crit Care Med, 2005, 171(10): 1185-1190.
35
Algin O, Gokalp G, Ocakoglu G, et al. Neurochemical-structural changes evaluati-on of brain in patients with obstructive sleep apnea syndrome[J]. Eur J Radiol, 2012, 81(3): 491-495. DOI: 10.1016/j.ejrad.2010.12.092.
36
Zhang WW, Zhao LP, Xie YP, et al. Correlation between hippocampal MR-S parameters and cognitive function in patients with obstructive sleep apnea h-ypopnea syndrome[J]. Chin J Med Imaging Technol, 2019, 35(8): 1175-1179. DOI: 10.13929/j.1003-3289.201811134.
37
Wang TT, Feng QX, Zhong XF, et al. A preliminary study of 1H-MRS on brain metabolism changes in children with obstructive sleep apnea hypopnea syndrome[J]. J Clin Radiol, 2019, 38(11): 2161-2165. DOI: 10.13437/j.cnki.jcr.2019.11.036.
38
Song X, Roy B, Kang DW, et al. Altered resting-state hippocampal and caudat-e functional networks in patients with obstructive sleep apnea[J]. Brain Behav, 2018, 8(6): e00994. DOI: 10.1002/brb3.994.
39
Kang DJ, Bao HH, Qin ZY. A study of obstructive sleep apnea hypopnea sy-ndrome secondary to erythrocytosis by fMRI in resting brain[J]. J Clin Radiol, 2019, 38(8): 1366-1370. DOI: 10.13437/j.cnki.jcr.20190828.003.
40
Huang Y, Liu Y, Zhao D, et al. Small-world properties of the whole-brain functional networks in patients with obstructive sleep apnea-hypopnea syndrome[J]. Sleep Med, 2019, 62: 53-58. DOI: 10.1016/j.sleep.2018.08.037.

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