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The principle of pH imaging with MR and its research progress on the formation mechanism and development of tumor acidic microenvironment
JIANG Weiqi  JIANG Meng  A Rong  SUN Xilin 

Cite this article as: Jiang WQ, Jiang M, A R, et al. The principle of pH imaging with MR and its research progress on the formation mechanism and development of tumor acidic microenvironment[J]. Chin J Magn Reson Imaging, 2021, 12(2): 121-124. DOI:10.12015/issn.1674-8034.2021.02.030.


[Abstract] Tumor tissues have unique pathophysiological characteristics, among which, the pH dysregulation becomes an important feature of the tumor microenvironment. Meanwhile, the acidic microenvironment of tumor plays a key role in malignant biological behaviors such as tumor development, invasion and metastasis. Therefore, it is of great significance to detect the pH of tumor extracellular environment for the early diagnosis of tumor, evaluating the occurrence and development of tumor and to monitor the clinical application of anticancer drugs. MRI can achieve non-invasive, in vivo, dynamic, real-time and quantitative characteristics in the imaging detection of tumor acidic microenvironment. It has the potential of diagnosing tumor earlier, guiding individual treatment as well as monitoring the curative effect of tumor treatment. This review based on the formation mechanism and pathophysiological significance of tumor acidic microenvironment, then summarizes the existing pH imaging with MR techniques and methods. In order to provide theoretical basis and data supporting for developing novel magnetic resonance pH imaging technology, thus promoting its clinical transformation and application.
[Keywords] magnetic resonance imaging；tumor acidic microenvironment；pH imaging；13C；19F；1H nuclear magnetic resonance spectroscopy

JIANG Weiqi   JIANG Meng   A Rong   SUN Xilin*  

Department of TOF-PET/CT/MR Center, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150028, China

Sun XL, E-mail: sunxl@ems.hrbmu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGENTS This work was part of National Nature Science Foundation of China (No. 81627901); National Basic Research Program of China (No. 2015CB931800).
Received  2020-07-20
Accepted  2020-08-21
DOI: 10.12015/issn.1674-8034.2021.02.030
Cite this article as: Jiang WQ, Jiang M, A R, et al. The principle of pH imaging with MR and its research progress on the formation mechanism and development of tumor acidic microenvironment[J]. Chin J Magn Reson Imaging, 2021, 12(2): 121-124. DOI:10.12015/issn.1674-8034.2021.02.030.

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