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• Clinical Article •
Clinical and imaging characteristics of cryptococcal intracranial infection in patients with acquired immune deficiency syndrome
YIN Yue  LI Hongjun 

Cite this article as: Yin Y, Li HJ. Clinical and imaging characteristics of cryptococcal intracranial infection in patients with acquired immune deficiency syndrome[J]. Chin J Magn Reson Imaging, 2021, 12(3): 24-29. DOI:10.12015/issn.1674-8034.2021.03.006.


[Abstract] Objective To investigate the clinical and imaging characteristics of cryptococcus meningitis (CM) in patients with acquired immunedeficiency syndrome (AIDS), thus to improve the diagnosis of this disease. Materials andMethods The clinical and imaging data of 20 AIDS patients with CM were retrospectively analyzed.Results Among the 20 cases, there were 17 males and 3 females. The age were ranged from 25 to 63 (median age 40.4); the CD4 counts were range from 1 to 162/μL (median number 26/μL). In cerebrospinal fluid, glucose was (2.45±1.090) mmol/L, and chlorine content was (119.86±4.669) mmol/L. Clinical symptoms included headache (80%), nausea and vomiting (15%), disturbance of consciousness (5%), blurred vision (5%) and fever (5%), 10% cases have no symptoms. On MRI, 11 cases were mainly characterized by dilated perivascular spaces (PVS) and pseudocyst, 6 cases were mainly characterized by meningitis/meningoencephalitis, 1 case presented both dilated PVS and meningitis/meningoencephalitis, 1 case presented with meningitis/meningoencephalitis and miliary nodules, 1 case presented other imaging feature.Conclusions The most common clinical symptom of AIDS patients with CM was headache, followed by nausea and vomiting. Imaging features included dilated PVS and pseudocyst.
[Keywords] acquired immunedeficiency syndrome；cryptococcus meningitis；magnetic resonance imaging；clinical feature；imaging feature

YIN Yue   LI Hongjun*  

Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China

Li HJ, Email: lihongjun00113@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  National Nature Science Foundation of China No. 61936013
Received  2020-10-14
Accepted  2021-01-21
DOI: 10.12015/issn.1674-8034.2021.03.006
Cite this article as: Yin Y, Li HJ. Clinical and imaging characteristics of cryptococcal intracranial infection in patients with acquired immune deficiency syndrome[J]. Chin J Magn Reson Imaging, 2021, 12(3): 24-29. DOI:10.12015/issn.1674-8034.2021.03.006.

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