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• Technical Article •
To investigate the impact of first pass reperfusion on functional outcome of acute stroke based on hypoperfusion intensity ratio
WU Han  GUO Qun  JIN Mingxu  PENG Mingyang  YIN Xindao  GAO Wei 

Cite this article as: Wu H, Guo Q, Jin MＸ, et al. To investigate the impact of first pass reperfusion on functional outcome of acute stroke based on hypoperfusion intensity ratio[J]. Chin J Magn Reson Imaging, 2021, 12(3): 34-38. DOI:10.12015/issn.1674-8034.2021.03.008.


[Abstract] Objects: To investigate the impact of first pass reperfusion (FPR) on functional outcome of acute stroke with different collateral circulation after endovascular thrombectomy (EVT). Materials andMethods A total of 180 acute stroke patients in our hospital were enrolled retrospectively. All patients underwent MR perfusion imaging and EVT therapy. Hypoperfusion intensity ratio (HIR) was used to evaluate collateral circulation. Good collateral circulation was defined as HIR＜0.4 and poor collateral circulation was defined as HIR≥0.4. FPR was defined as achieving modified Thrombolysis in Cerebral Infarction (mTICI) 2b-3 after a single pass of the device. Statistical methods were performed to analyze the impact of FPR on the outcome in acute stroke with different collateral circulation after EVT therapy.Results For patients with HIR≥0.4 (n=72), compared with non-FPR group (n=30), the mortality rate at 3 months (11.90% vs. 33.33%) was lower and good functional outcome at 3 months (59.52% vs. 33.33%) was higher in FPR group (n=42). For patients with HIR＜0.4 (n=108), the mortality rate at 3 months and good functional outcome at 3 months had no significant differences between two group (P＞0.05). Logistic regression analysis showed that FPR was an independent predictor of good functional outcome in acute stroke patients with HIR≥0.4 (OR=2.281, 95% CI: 1.419—5.286; P=0.018). While FPR had no significant difference in predicting the good functional outcome in acute stroke patients with HIR＜0.4 (OR=1.693, 95% CI: 0.596－4.798; P=0.319).Conclusions The effect of FPR on functional outcome is highly dependent on collateral circulation. When the collateral circulation is poor (HIR≥0.4), the effect of FPR on functional outcome is more prominent.
[Keywords] stroke；magnetic resonance imaging；perfusion weighted imaging；endovascular thrombectomy therapy；functional outcome

WU Han   GUO Qun   JIN Mingxu   PENG Mingyang   YIN Xindao   GAO Wei*  

Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 21006, China

Gao W, E-mail: gao1974@yeah.net

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the Jiangsu Science and Technology Development Project No. BE2017614 This article is supported by the Medical and Health Research Project of Nanjing Health and Family Planning Commission No. YKK18101
Received  2020-10-16
Accepted  2021-01-21
DOI: 10.12015/issn.1674-8034.2021.03.008
Cite this article as: Wu H, Guo Q, Jin MＸ, et al. To investigate the impact of first pass reperfusion on functional outcome of acute stroke based on hypoperfusion intensity ratio[J]. Chin J Magn Reson Imaging, 2021, 12(3): 34-38. DOI:10.12015/issn.1674-8034.2021.03.008.

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