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Correlation between DCE-MRI parameters/ADC and pathological molecular prognostic markers of breast cancer
WANG Jie  TANG Wenwei  TIAN Zhongfu  ZHENG Jinxia  WANG Feng 

Cite this article as: Wang J, Tang WW, Tian ZF, et al. Correlation between DCE-MRI parameters/ADC and pathological molecular prognostic markers of breast cancer[J]. Chin J Magn Reson Imaging, 2021, 12(3): 76-79. DOI:10.12015/issn.1674-8034.2021.03.017.


[Abstract] Objective To analyze the correlation between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters/apparent diffusion coefficient (ADC) and pathological molecular prognostic markers of breast cancer. Materials andMethods The clinical data of 106 patients with breast cancer in our hospital were retrospectively analyzed. The differences in DCE-MRI parameters and ADC were compared between patients with the positive expressions and negative expressions of estrogen receptor (ER), progesterone receptor (PR), cell proliferation antigen Ki67 and androgen receptor (AR). The correlation between DCE-MRI parameters, ADC and expressions of ER, PR , Ki67 and AR was analyzed.Results After Spearman rank correlation test, it was found that the positive expressions of ER, PR and AR were significantly negatively correlated with diameter and marginal burr (P＜0.05), and the positive expression of AR was also significantly positively correlated with time to peak (TTP) and ADC (P＜0.05). The positive expression of Ki67 was significantly positively correlated with diameter and marginal burr (P＜0.05), and was significantly negatively correlated with TTP and ADC (P＜0.05).Conclusions DCE-MRI morphological parameters and TTP and ADC have a certain correlation with molecular biological markers of breast cancer, and they are beneficial to the prognosis of breast cancer.
[Keywords] breast cancer；dynamic contrast-enhanced magnetic resonance imaging；apparent diffusion coefficient；molecular biological markers；Ki67

WANG Jie1   TANG Wenwei1   TIAN Zhongfu1   ZHENG Jinxia1   WANG Feng2*  

1 Department of Radiology, Women's Hospital of Nanjing Medical University, Nanjing 210000, China

2 Department of Nuclear Medicine, Nanjing Affiliated Hospital of Nanjing Medical University (Nanjing First Hospital), Nanjing 210000, China

Wang F, E-mail: fengwangcn@hotmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Maternal and Child Health Research Project of Jiangsu Province No. F201829
Received  2020-10-27
Accepted  2021-01-21
DOI: 10.12015/issn.1674-8034.2021.03.017
Cite this article as: Wang J, Tang WW, Tian ZF, et al. Correlation between DCE-MRI parameters/ADC and pathological molecular prognostic markers of breast cancer[J]. Chin J Magn Reson Imaging, 2021, 12(3): 76-79. DOI:10.12015/issn.1674-8034.2021.03.017.

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