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• Clinical Article •
Quantitative evaluation of sacroiliac arthritis activity in SpA based on DCE-MRI microvascular permeability parameters
LIN Mingui  CHEN Xianyuan  YU Shun  MA Mingping 

Cite this article as: Lin MG, Chen XY, Yu S, et al. Quantitative evaluation of sacroiliac arthritis activity in SpA based on DCE-MRI microvascular permeability parameters[J]. Chin J Magn Reson Imaging, 2021, 12(4): 39-44. DOI:10.12015/issn.1674-8034.2021.04.008.


[Abstract] Objective The study explored the feasibility of using dynamic contrast-enhanced MRI (DCE-MRI) microvascular permeability parameters to quantitatively evaluate changes of sacroiliac joint in axial spondyloarthritis (SpA), in order to provide a quantitative index for the evaluation of sacroiliac joint inflammatory activity in SpA. Materials andMethods A total of 65 patients with clinically diagnosed SpA were included as the case group and 18 normal subjects excluded from the diagnosis of SpA were taken as the control group. The case group was divided into active group and inactive group according to ankylosing spondylitis disease activity score (ASDAS). All subjects were scanned by routine MRI and DCE-MRI of sacroiliac joint. The quantitative osmotic parameters, quantitative perfusion parameters and semi-quantitative parameters of sacroiliac joint were measured by Omni-Kinetics post-processing software. The differences of different parameters between case group and control group, and active group and inactive group were compared to find quantitative indexes with statistical significance.Results ①The values of quantitative parameters Ktrans, Kep, Ve and semi-quantitative parameter TTP in the case group were 0.1315, 1.7467, 0.0887 and 1.9744 respectively, which were significantly higher than those in the control group (0.0281, 0.8559, 0.0469, 1.2204) (all P＜0.05). ②The values of quantitative parameters Ktrans, Kep, Ve and semi-quantitative parameters TTP in active group were 0.1574, 1.8710, 0.0960 and 2.1790, respectively, which were significantly higher than those in inactive group (0.0892, 1.1987, 0.0744, 1.8412) (all P＜0.05). ③Ktrans was highly correlated with ASDAS-CRP (r=0.663), which was better than that of Kep (r=0.286) and Ve (r=0.441).Conclusions Dynamic enhancement of SpA microvascular permeability parameters can directly reflect the microcirculation perfusion state of sacroiliac joint and provide an effective quantitative index for the evaluation of inflammatory activity in sacroiliac joint.
[Keywords] dynamic contrast-enhanced；magnetic resonance imaging；microvascular permeability parameters；quantitative analysis；axial spinal arthritis

LIN Mingui   CHEN Xianyuan   YU Shun*   MA Mingping  

Shengli Clinical Medical College of Fujian Medical University, Department of Radiology of Fujian Provincial Hospital, Fuzhou 350001, China

Yu S, E-mail: 76429310@qq.com

Conflicts of interest   None.

This work was part of Natural Science Foundation of Fujian Province (No. 2017J01172, 2019J05133); China International Medical SKY Foundation Sky Imaging Research Fund Development Project (No. Z-2014-07-1912-14).
Received  2020-11-16
Accepted  2021-01-27
DOI: 10.12015/issn.1674-8034.2021.04.008
Cite this article as: Lin MG, Chen XY, Yu S, et al. Quantitative evaluation of sacroiliac arthritis activity in SpA based on DCE-MRI microvascular permeability parameters[J]. Chin J Magn Reson Imaging, 2021, 12(4): 39-44. DOI:10.12015/issn.1674-8034.2021.04.008.

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