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• Original Article •
Functional connectivity between prefrontal lobe and thalamus and its relationship with individual's craving for internet game: A rs-fMRI study
CHEN Jing  HUANG Pujiang  YANG Guang  LIU Zhiyuan 

Cite this article as: Chen J, Huang PJ, Yang G, et al. Functional connectivity between prefrontal lobe and thalamus and its relationship with individual's craving for Internet game: a rs-fMRI study[J]. Chin J Magn Reson Imaging, 2021, 12(4): 45-50. DOI:10.12015/issn.1674-8034.2021.04.009.


[Abstract] Objective By using functional magnetic resonance imaging (fMRI) technique, the current study aimed to investigate the difference in resting-state functional connectivity (rsFC) between Internet gaming disorder (IGD) group and healthy control (HC) group, and the relationship between this rsFC and the individual's craving for Internet game. Materials andMethods Participants were classified into two groups according to the Internet game application questionnaire and the Internet game addiction diagnostic scale, a total of 32 participants for IGD group and 33 participants for HC group were recruited. All participants filled out the Internet game craving scale and underwent a resting-state scan in the MRI scanner to obtain accurate brain data. We chose the right superior frontal gyrus (SFG) as the region of interest (ROI), and calculated the rsFC between the right SFG and other brain regions. Then, we compared the differences in the rsFC between IGD group and HC group, and found the brain regions which were significantly different between two groups. After that we analyzed the correlation between the scores of Internet game craving scale and those brain regions of which the rsFC were significant different between the two groups.Results Compared with HC group, IGD group showed significantly higher levels of craving for Internet game, and IGD group also showed significantly increased rsFC between the SFG and thalamus. In HC group, the rsFC between the SFG and thalamus was positively correlated with the scores of Internet game craving scale (r=0.365, P＜0.05), while this correlation was not found in IGD group (r=-0.286, P=0.119).Conclusions IGD group maintained a high degree of craving for Internet game. Moreover, the rsFC between the SFG and thalamus was abnormal in IGD group, which means the rsFC was significantly enhanced in IGD group while compared with HC group. In addition, the rsFC between the SFG and thalamus was related to the degree of craving for Internet game in HC group.
[Keywords] internet gaming disorder；prefrontal lobe；resting-state functional connectivity；craving；functional magnetic resonance imaging

CHEN Jing1, 2   HUANG Pujiang3   YANG Guang1, 2*   LIU Zhiyuan3*  

1 Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China

2 School of Physics and Electronic Science, East China Normal University, Shanghai 200062, China

3 School of Psychology, Shaanxi Normal University, Xi'an 710062, China

Liu ZY, E-mail: zyliu@snnu.edu Yang G, E-mail: gyang@phy.ecnu.edu.cn

Conflicts of interest   None.

This work was part of National Natural Science Foundation of China (No. 31900754); the Young Talent Fund of University Association for Science and Technology in Shaanxi, China (No. 20200308).
Received  2020-11-16
Accepted  2021-01-28
DOI: 10.12015/issn.1674-8034.2021.04.009
Cite this article as: Chen J, Huang PJ, Yang G, et al. Functional connectivity between prefrontal lobe and thalamus and its relationship with individual's craving for Internet game: a rs-fMRI study[J]. Chin J Magn Reson Imaging, 2021, 12(4): 45-50. DOI:10.12015/issn.1674-8034.2021.04.009.

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