3D mDixon Quant based on compressed SENSE for quantitative study of lumbar vertebral body fat content

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• Technical Article •

SONG Yu SONG Qingwei ZHANG Haonan ZHANG Nan PU Renwang LIU Ailian MIAO Yanwei

Cite this article as: Song Y, Song QW, Zhang HN, et al. 3D mDixon Quant based on compressed SENSE for quantitative study of lumbar vertebral body fat content[J]. Chin J Magn Reson Imaging, 2021, 12(4): 51-56. DOI:10.12015/issn.1674-8034.2021.04.010.

Abstract

[Abstract] Objective To investigate the effects of different acceleration factors (AF) on lumbar vertebra fat quantification using 3D mDixon Quant sequence accelerated by sensitivity coding (SENSE) and compressed SENSE (CS-SENSE), and analyze the relationship among lumbar body fat fraction (FF), age, sex and body mass index (BMI). Materials andMethods From January to July 2020, 96 healthy volunteers were recruited, including 45 males and 51 females, from 16 to 79 years old, with an average age of 43.85±17.98 years. Volunteers were divided into three groups according to age: young group (＜40 years old), middle-aged group (40—60 years old), and elderly group (＞60 years old). All volunteers were imaged at Philips Ingenia CX 3.0 T MRI with a fat quantification sequence (3D mDixon Quant) for the entire lumbar spine, and the sequence was accelerated at different folds with either SENSE (acceleration factor S=2, 4) or CS-SENSE (acceleration factor CS=2, 3, 4, 5, 6, 7, 8). FF, signal-noise-ratio (SNR), and contrast-noise-ration (CNR) were measured for the L1—L5 vertebra by two radiologists independently with a double-blind method, measurement carried out on a IntelliSpace Portal workstation (ISP version 7.0; Philips Healthcare, Best, the Netherlands). The measured parameters were compared among different AFs.Results The measurement results of the two observers showed good agreement (ICC value＞0.75). There was no statistically significant difference in the FF values measured by 3D mDixon Quant sequence with different AF (P=0.653), but there were statistically significant differences in SNR and CNR with different AF (P=0.001, 0.006). Among them, there were statistically significant differences in SNR and CNR between CS3 and CS7 groups, CS4 and CS7 groups, and CS4 and CS8 groups (P＜0.05). The scanning time of CS6 was 60.66% shorter than that of SENSE 2, but there were no statistically significant differences in FF values, SNR and CNR values compared with those of other groups (S2, S4, CS2, CS3, CS4 and CS5) (P＞0.05). FF values were significantly different between the three age groups (F=20.876, P＜0.01). Among them, FF of the young group was significantly lower (P＜0.01) than that of the middle-aged and the elderly groups, while the difference between the middle-aged and the elderly groups was not statistically significant (P=0.086). In the young group, the lumbar vertebra FF of the male was higher than that of the female (P＜0.05), while in the middle-aged group and the elderly group, the FF of the male was slightly lower than that of the female, albeit not significantly (P＞0.05). The lumbar vertebrae FF in men was moderately positively correlated with BMI (r=0.634, P＜0.01), while in females such correlation was not observed (r=0.207, P=0.146).Conclusions The 3D mDixon Quant sequence combined with CS technology is reliable for assessing the lumbar vertebral body fat content. When the maximum AF of CS was selected to 6, the image quality and the measurement accuracy were maintained while the imaging time dramatically reduced. Age, gender, and BMI are all factors that may affect the lumbar vertebra fat content. These factors should be considered in the analysis and evaluation of lumbar vertebra fat content in different individuals.

[Keywords] magnetic resonance imaging；lumbar spine；fat content；3D mDixon Quant；compressed SENSE；acceleration factors

Contributor Information

SONG Yu^{1,
2} SONG Qingwei^2* ZHANG Haonan² ZHANG Nan² PU Renwang² LIU Ailian² MIAO Yanwei²

¹ Department of Radiology, West China Second University, Sichuan University, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defect of Ministry of Education, Chengdu 610041, China

² Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

Song QW, E-mail: songqw1964@163.com

Conflicts of interest None.

Publication Information

This work was part of National Natural Science Foundation of China (No. 81901712).

Received 2020-12-17

Accepted 2021-02-10

DOI: 10.12015/issn.1674-8034.2021.04.010

Text

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