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• Clinical Article •
Predictive value of susceptibility vessel sign for long-term neurologic outcomes in elder patients with malignant middle cerebral artery infarct
ZHAO Jingwei  WU Lei  ZHANG Shaolan  TIAN Duxue  SUI Xin  SHI Guangzhi  ZHOU Jianxin 

Cite this article as: Zhao JW, Wu Lei, Zhang SL, et al. Predictive value of susceptibility vessel sign for long-term neurologic outcomes in elder patients with malignant middle cerebral artery infarct[J]. Chin J Magn Reson Imaging, 2021, 12(5): 1-5. DOI:10.12015/issn.1674-8034.2021.05.001.


[Abstract] Objective To investigate the predictive value of susceptibility vessel sign (SVS) on susceptibility weighted imaging (SWI) for long-term neurologic prognosis in elder patients with malignant middle cerebral artery infarct (mMCAI). Materials andMethods Thirty-one mMCAI patients aged more than 60 years who had underwent decompressive hemicraniotomy (DHC) were respectively screened. We dichotomized them based on 12-month modified Rankin Scale (mRS) to those with favorable (mRS 0—3) and unfavorable (mRS 4—6), and the 2 groups were compared on differences in baseline, clinical and neuroimaging data, including the findings of SWI tests.Results The univariate and multivariate logistics analysis for these 2 groups of patients identified an independent association of the positive SVS with the long-term neurologic outcomes in elder mMCAI patients (adjusted OR=18.655, 95% CI 1.129 to 308.173; P=0.041), and this sign also showed a good agreement rate with the recanalization of the cerebral arteries which were responsible for the stroke manifested on MRA (Kappa=0.842, P=0.020). However, SVS only presented a good specificity (0.905, 95% CI 0.699—0.988) for the neurologic outcomes in elder mMCAI patients without a favorable sensitivity (0.700, 95% CI 0.348—0.933).Conclusions SVS can independently predict the long-term neurologic prognosis of elder patients with mMCAI, and particularly its negative results can accurately predict the poor outcomes of these patients.
[Keywords] susceptibility weighted imaging；susceptibility vessel sign；malignant middle cerebral artery infarct；elder ages；outcomes

ZHAO Jingwei1   WU Lei1   ZHANG Shaolan1   TIAN Duxue2   SUI Xin2*   SHI Guangzhi1*   ZHOU Jianxin1  

1 Department of Critical Care, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

2 Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China

Sui X, E-mail: lena_sui@163.com Shi GZ, E-mail: shiguangzhi@bjtth.org

Conflicts of interest   None.

ACKNOWLEDGMENTS This article is supported by Sailing Project for Key Medical Specialties of Beijing Hospitals Authority (No. ZYLX202109) and the Capital Characteristic Study of Clinical Application (No. Z181100001718068).
Received  2020-12-10
Accepted  2021-03-25
DOI: 10.12015/issn.1674-8034.2021.05.001
Cite this article as: Zhao JW, Wu Lei, Zhang SL, et al. Predictive value of susceptibility vessel sign for long-term neurologic outcomes in elder patients with malignant middle cerebral artery infarct[J]. Chin J Magn Reson Imaging, 2021, 12(5): 1-5. DOI:10.12015/issn.1674-8034.2021.05.001.

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