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• Clinical Article •
The value of minimum apparent diffusion coefficient in evaluating the invasiveness of hepatocellular carcinoma
JING Mengyuan  CAO Yuntai  DENG Juan  ZHANG Peng  ZHANG Jing  ZHANG Bin  ZHOU Junlin 

Cite this article as: Jing MY, Cao YT, Deng J, et al. The value of minimum apparent diffusion coefficient in evaluating the invasiveness of hepatocellular carcinoma[J]. Chin J Magn Reson Imaging, 2021, 12(5): 16-20. DOI:10.12015/issn.1674-8034.2021.05.004.


[Abstract] objective To evaluate the invasiveness of hepatocellular carcinoma (HCC) by using the minimum apparent diffusion coefficient (ADCmin). Materials andMethods The 85 patients with HCC confirmed by pathology and examined by MRI diffusion weighted imaging (DWI) before operation from January 2015 to October 2020 were analyzed retrospectively.The clinical and pathological information were recorded and the tumor ADCmin was measured on ADC images. Statistical methods were used to evaluate the correlation between clinical information, ADCmin and microvascular invasion (MVI), histological differentiation and Ki-67 expression. The independent factors related to the invasiveness of HCC were screened by binary Logistic regression, and the diagnostic efficiency was evaluated by ROC curve.Results The size of tumor was related to HCC MVI and the histological differentiation (P＜0.05). The difference of ADCmin between the two groups in MVI were statistically significant (0.87±0.15 vs. 1.14±0.24, P＜0.05). The AUC value of MVI judged by ADCmin was 0.866 (95% CI, 0.770—0.962). The difference of ADCmin between the two groups in histological differentiation were statistically significant (0.91±0.18 vs. 1.09±0.25, P＜0.05), and the AUC value of using ADCmin to predict the degree of HCC differentiation was 0.739 (95% CI, 0.608—0.870). There were significant difference in ADCmin between the two groups of Ki-67 (1.19±0.24 vs. 1.03±0.25, P＜0.05). The AUC value of Ki-67 predicted by ADCmin was 0.723 (95% CI, 0.576—0.871).Conclusion This study showed that ADCmin had great clinical value in preoperative non-invasive evaluation of the invasiveness of HCC and can greatly improve the prognosis of patients.
[Keywords] hepatocellular carcinoma；magnetic resonance imaging；apparent diffusion coefficient；microvascular invasion；histological differentiation；Ki-67

JING Mengyuan1, 2, 3   CAO Yuntai1, 2, 3   DENG Juan1, 2, 3   ZHANG Peng4   ZHANG Jing1, 2, 3   ZHANG Bin1, 2, 3   ZHOU Junlin1, 2, 3*  

1 Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China

2 Second Clinical School, Lanzhou University, Lanzhou 730030, China

3 Key Laboratory of Medical Imaging of Gansu Province, Lanzhou 730030, China

4 Department of Pathology, Lanzhou University Second Hospital, Lanzhou 730030, China

Zhou JL, E-mail: lzuzjl601@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS This work was part of National Natural Science Foundation of China (No. 81772006).
Received  2020-12-07
Accepted  2021-03-25
DOI: 10.12015/issn.1674-8034.2021.05.004
Cite this article as: Jing MY, Cao YT, Deng J, et al. The value of minimum apparent diffusion coefficient in evaluating the invasiveness of hepatocellular carcinoma[J]. Chin J Magn Reson Imaging, 2021, 12(5): 16-20. DOI:10.12015/issn.1674-8034.2021.05.004.

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