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• Clinical Article •
The correlation between the expression of matrix metalloproteinase-1 and magnetic resonance T2-mapping in talus osteochondral injury
LI Wei  YU Zechen  JIA Yanbo  YU Jinghong  HAI Ling  WU Rihan  BAI Xinyu 

Cite this article as: Li W, Yu ZC, Jia YB, et al. The correlation between the expression of matrix metalloproteinase-1 and magnetic resonance T2-mapping in talus osteochondral injury[J]. Chin J Magn Reson Imaging, 2021, 12(5): 44-49. DOI:10.12015/issn.1674-8034.2021.05.010.


[Abstract] Objective To investigate the relationship between the expression of matrix metalloproteinase-1 (MMP-1) and magnetic resonance (MR) T2 value and its mechanism in talus osteochondral injury (OLT). Materials andMethods Thirty cases of ankle OLT patients under minimally invasive therapy and 30 healthy volunteers were collected. 3.0 T routine MR and T2-mapping scans were performed and T2 values were measured. The HE staining of the talus cartilage during the operation were used and the Western Blot method were used to measure the expression of MMP-1. The correlation between the T2 value of MR and the content of MMP-1 was statistically analyzed.Results OLT was most common in the medial central of the talus (MRI 6 zoning method). The T2 value increased with the severity of the cartilage degeneration under Mankin grade, and the difference was statistically significant (P＜0.05). The expression of MMP-1 was significantly different between high-grade and low-grade (P＜0.05). The cartilage T2 value and MMP-1 expression showed a linear trend. Pearson correlation analysis showed a linear positive correlation between the two (r=0.821, P＜0.0001).Conclusions OLT is most common in the medial central side of the talus. The T2 value of MRI increased with the degrade of cartilage injury. The T2 value of OLT showed a positive correlation with the determination of MMP-1. T2-mapping functional imaging could provide a quantitative imaging basis for clinical treatment of OLT by predict the expression of MMP-1 protein in different grades of cartilage injury in vivo and noninvasion.
[Keywords] talus osteochondral；T2-mapping；quantitative analysis；matrix metalloproteinase-1；magnetic resonance imaging

LI Wei1   YU Zechen2   JIA Yanbo3   YU Jinghong1*   HAI Ling4   WU Rihan5   BAI Xinyu5  

1 Department of Imaging, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China

2 Siemens Healthineers Co., Ltd, Shanghai 201318, China

3 Department of Sports Medical Surgery, Second Affiliated Hospital of Inner Mongolia Medical University Hohhot 010030, China

4 Collage of Basic Medicine of Inner Mongolia Medical University, Hohhot 010110, China

5 The First College of Clinical Medicine of Inner Mongolia Medical University, Hohhot 010059, China

Yu JH, E-mail: yujinghong200@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Inner Mongolia Autonomous Region (No. 2018MS08024). Science and Technology Project of Inner Mongolia Autonomous Region (No. 2019GG053). Inner Mongolia Medical University "Youth Pilot Innovation" Team (No. QNLC-2020035).
Received  2021-01-19
Accepted  2021-03-25
DOI: 10.12015/issn.1674-8034.2021.05.010
Cite this article as: Li W, Yu ZC, Jia YB, et al. The correlation between the expression of matrix metalloproteinase-1 and magnetic resonance T2-mapping in talus osteochondral injury[J]. Chin J Magn Reson Imaging, 2021, 12(5): 44-49. DOI:10.12015/issn.1674-8034.2021.05.010.

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