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• Technical Article •
Synthetic MRI of the hippocampal application value of normal adults
WU Wenhao  YU Wenjun  ZHU Dantian  QIAN Long  LI Shaolin 

Cite this article as: Wu WH, Yu WJ, Zhu DT, et al. Synthetic MRI of the hippocampal application value of normal adults[J]. Chin J Magn Reson Imaging, 2021, 12(5): 55-59. DOI:10.12015/issn.1674-8034.2021.05.012.


[Abstract] Objective To explore the application value of synthetic magnetic resonance technology (SyMRI) in the quantitative measurement of the hippocampus in normal adults. Materials andMethods A total of 139 healthy adults aged 20 to 72 were collected, including 61 males and 78 females. According to age, they were divided into three groups (20—35 years old) 36 cases, (36—55 years old) 72 cases, (56—72 years old) 31 cases. All subjects were examined with GE SIGNA Pioneer 3.0 T MRI. The scanning sequence included 3D-TWI damage gradient echo sequence (3D T1WI-SPGR) and SyMRI sequence. The whole brain was automatically registered and extracted by SyMRI post-processing software. The hippocampal T1, T2 and proton density (PD) values of both sides were tested by paired t-test. The hippocampal T1, T2 and PD values of different gender groups were tested by two independent samples Mann-Whitney U test, the analysis of variance was used among different age groups, and the pairwise comparison among different age groups was performed by LSD method.Results The mean values of T1, T2 and PD in 139 healthy adults were (1258.43±110.59) ms, (105.88±16.05) ms, (74.71±1.52) pu, respectively. The range of T1 value, T2 value, and PD value were (1070.16—1725.59) ms, (86.43—190.71) ms, (70.72—80.21) pu. There were significant differences in T1 and PD values of hippocampus in different sides (P＜0.05), and the values of T1 and PD on the left side were higher than those on the right side. There was no significant difference in T2 values between different sides of hippocampus and T1, T2 and PD values between sexes (P＞0.05). There were significant differences in T1, T2 and PD values among different age groups (P＜0.05). There were significant differences between 20 to 35 years old group, 36 to 55 years old group and 56 to 72 years old group (P＜0.05). There was no significant difference between 20 to 35 years old group and 36 to 55 years old group (P＞0.05).Conclusions SyMRI can provide quantitative reference values of hippocampus in normal adults of different ages and genders, and provide an important basis for early diagnosis of hippocampal related diseases.
[Keywords] aging；sex；hippocampus；synthetic magnetic resonance imaging；quantification

WU Wenhao1   YU Wenjun1   ZHU Dantian1   QIAN Long2   LI Shaolin1*  

1 Department of Radiology, Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 519000, China

2 MR Research, GE Healthcare, Beijing 100000, China

Li SL, E-mail: lishlin5@mail.sysu.edu.cn

Conflicts of interest   None.

Received  2020-12-18
Accepted  2021-03-25
DOI: 10.12015/issn.1674-8034.2021.05.012
Cite this article as: Wu WH, Yu WJ, Zhu DT, et al. Synthetic MRI of the hippocampal application value of normal adults[J]. Chin J Magn Reson Imaging, 2021, 12(5): 55-59. DOI:10.12015/issn.1674-8034.2021.05.012.

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