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Study on the correlation between MRI diffusion-weighted imaging apparent diffusion coefficient and Ki-67 index of triple negative and non-triple negative breast cancer
QIAN Jifang  ZHANG Rong  ZHAO Li  LI Yunzhi  XU Shengfang  YANG Aiping 

Cite this article as: Qian JF, ZHANG R, ZHAO L, et al. Study on the correlation between MRI diffusion-weighted imaging apparent diffusion coefficient and Ki-67 index of triple negative and non-triple negative breast cancer[J]. Chin J Magn Reson Imaging, 2021, 12(5): 69-72. DOI:10.12015/issn.1674-8034.2021.05.015.


[Abstract] Objective To explore the the utility of the minimum apparent diffusion coeffcient (ADC), average ADC, maximum ADC, and ADC difference value and to find optimum ADC parameters for differentiation between triple negative and non-triple negative breast cancer in diffusion-weighted imaging (DWI),and further investigated the relationship between ADC values and the Ki-67 proliferation index. Materials andMethods One hundred and forty-eight patients, who underwent breast MRI and collectively had 148 pathologically proven invasive carcinomas, were retrospectively enrolled. The apparent diffusion coefficient (ADC) value of the breast cancer lesions with each molecular subtype were identified and assessed jointly. all patients were female, aged 25—80 (51.4±10.5) years, 28 case TNBC and 120 case nTNBC patients. Receiver operating characteristic curves were drawn to evaluate the differentiating accuracy of ADC values. The Ki-67 proliferation index of the solid tumor components was also measured to explore its relationship with ADC values.Results Statistical analysis of ADC values showed that ADCmean [(0.769±0.117) vs. (0.897±0.088)×10-3 mm2/s] and ADCmin [(0.633±0.091) vs. (0.712±0.121)×10-3 mm2/s] were significantly lower in TNBC than nTNBC (all P＜0.05). The ADCDR of TNBC was significantly higher than that of nTNBC [(0.692±0.082) vs. (0.468±0.133)×10-3 mm2/s], P＜0.05). ADCmax value was not statistically significant (P＞0.05) in the two groups. ADCDR best distinguished the two groups, with an area under the curve value of 0.925. Using 0.635×10-3 mm2/s as the optimal threshold, the sensitivity, specificity of the two groups were 78.6%, 93.3%, respectively. ADCmean (r=-0.321) and ADCmin (r=-0.316) showed significant negative correlations with the Ki-67 proliferation index, ADCmax (r=0.249) and ADCmin (r=0.447) showed significant positive correlations with the Ki-67 proliferation index (all P＜0.01).Conclusions Quantitative analysis of ADC value can identify TNBC and nTNBC. ADCDR value may be the best single parameter for DWI to identify the two groups, and there is a certain correlation between ADC value and Ki-67 proliferation index.
[Keywords] triple negative breast cancer；magnetic resonance imaging；apparent diffusion coefficient；Ki-67；correlation

QIAN Jifang1   ZHANG Rong2*   ZHAO Li1   LI Yunzhi1   XU Shengfang1   YANG Aiping1  

1 Medical Imaging Center, Gansu Provincial Maternity and Child-care Hospital, Lanzhou 730050, China

2 The Second Clinical Medical College of Lanzhou University, Lanzhou 730030, China

Zhang R, E-mail: zhangronglzu@163.com

Conflicts of interest   None.

Received  2020-12-21
Accepted  2021-03-25
DOI: 10.12015/issn.1674-8034.2021.05.015
Cite this article as: Qian JF, ZHANG R, ZHAO L, et al. Study on the correlation between MRI diffusion-weighted imaging apparent diffusion coefficient and Ki-67 index of triple negative and non-triple negative breast cancer[J]. Chin J Magn Reson Imaging, 2021, 12(5): 69-72. DOI:10.12015/issn.1674-8034.2021.05.015.

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