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Assessment of angiogenesis and differentiation grade of extrahepatic cholangiocarcinoma by diffusion weighted imaging
WU Xin  HUANG Xinqiao  SHU Jian  SU Song  ZHOU Tiejun 

Cite this article as: Wu X, Huang XQ, Shu J, et al. Assessment of angiogenesis and differentiation grade of extrahepatic cholangiocarcinoma by diffusion weighted imaging[J]. Chin J Magn Reson Imaging, 2021, 12(5): 73-76. DOI:10.12015/issn.1674-8034.2021.05.016.


[Abstract] Objective To explore the value of apparent diffusion coefficient (ADC) value in evaluating angiogenesis and differentiation grade of extrahepatic cholangiocarcinoma (EHCC). Materials andMethods A retrospective analysis of 88 cases of EHCC confirmed by surgery and pathology in our hospital from August 2011 to December 2017 was performed.Preoperative MR-DWI examination was performed and ADC value was measured.The correlation between ADC value and microvessel density (MVD) was calculated. According to the expression of vascular endothelial growth factor (VEGF), all cases were divided into negative group and positive group. Then, according to the differentiation grade,it was divided into well, medium and poorly differentiated groups. Next, ADC value was compared between groups, and receiver operating characteristic (ROC) curve was used to evaluate the ADC value to judge the performance of VEGF expression and differentiation grade.Results There was a negative correlation between ADC value and MVD (rs=-0.726, P＜0.05). The ADC value of the VEGF expression positive group was significantly smaller than that of the negative group (U=406. 50, P＜0.05). The ADC value＜1.291×10-3 mm2/s can predict the VEGF positive expression with the AUC value of 0.790, the sensitivity of 71. 43% and the specificity of 78.26%. As the differentiation grade decreased, the ADC value of EHCC gradually declined (χ2=72.51, P＜0.05), and pairwise comparison between groups showed statistically significant difference (P＜0.05). The ADC value＞1.319×10-3 mm2/s can predict the well differentiated group with the AUC value of 0.986, the sensitivity of 96.77% and the specificity of 89.47%. The ADC value＜1.184×10-3 mm2/s can predict the poorly differentiated group with the AUC value of 0.998, the sensitivity of 100% and the specificity of 97.10%.Conclusions The ADC value of EHCC is related to MVD and it can predict the VEGF expression and differentiation grade.
[Keywords] extrahepatic cholangiocarcinoma；diffusion weighted imaging；apparent diffusion coefficient；angiogenesis；differentiation grade

WU Xin1   HUANG Xinqiao1   SHU Jian1*   SU Song2   ZHOU Tiejun3  

1 Department of Radiology, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

2 Department of Hepatobiliary Surgery, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

3 Department of Pathology, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

Shu J, E-mail: shujiannc@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS This work was part of Research Project of Health Commission of Sichuan Province (No. 19PJ151).
Received  2020-11-05
Accepted  2021-01-21
DOI: 10.12015/issn.1674-8034.2021.05.016
Cite this article as: Wu X, Huang XQ, Shu J, et al. Assessment of angiogenesis and differentiation grade of extrahepatic cholangiocarcinoma by diffusion weighted imaging[J]. Chin J Magn Reson Imaging, 2021, 12(5): 73-76. DOI:10.12015/issn.1674-8034.2021.05.016.

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