Relationship between FVH sign and brain oxygen metabolism of SWI sequence and clinical state in patients with acute/subacute cerebral infarction

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• Clinical Article •

CHANG Peipei MIAO Yanwei JIANG Yuhan CHE Yiwei GAO Bingbing CHEN Lihua SONG Qingwei LIU Ailian

Cite this article as: Chang PP, Miao YW, Jiang YH, et al. Relationship between FVH sign and brain oxygen metabolism of SWI sequence and clinical state in patients with acute/subacute cerebral infarction[J]. Chin J Magn Reson Imaging, 2021, 12(6): 5-9, 77. DOI:10.12015/issn.1674-8034.2021.06.002.

Abstract

[Abstract] Objective To investigate the correlation of flair vascular hyperintensity (FVH) with brain venous blood oxygen metabolism and explore the relationship between FVH score and asymmetrically prominent cortical veins (APCVs) score, phase difference value (Δφ), the rato of phase difference value (rΔφ), NIHSS score, infarct volume in patients with acute or subacute cerebral infarction. Materials andMethods Thirty-four acute or subacute cerebral infarction patients were prospectively collected. The clinical base data of all patients were recorded, and the National Institute of Health stroke scale (NIHSS) scores at admission and discharge were evaluated (NIHSSadmission, NIHSSdischarged). All subjects underwent conventional MRI and diffusion-weighted imaging (DWI), susceptibility-weighted imaging (SWI) sequences. The degree of MCA stenosis, FVH score and APCVs score were measured and evaluated independently by two radiologists. The phase difference value (Δφ) and ratio (rΔφ) of veins around infarct area were measured and calculated and the infarct core volume was measured. All patients were divided into mild-moderate stenosis group and severe-occlusion group, the differences of FVH and APCVs scores between the two groups were compared with independent t-test. Spearman correlation analysis were separately used to analyze the relationships between FVH scores and APCVs score, Δφ, rΔφ, NIHSS score, infarct volume in three groups (whole, mild-moderate stenosis group and severe-occlusion group). The influencing factors of FVH score were analyzed by multiple linear regression.Results In thirty-four patients with unilateral MCA stenosis and cerebral infarction, the scores of FVH and APCVs in the severe-occlusion group were significantly higher than those in the mild-moderate group (t=2.29, P=0.03; t=4.89, P＜0.001). On unified comparison, FVH score was positively correlated with APCVs score, rΔφ, NIHSSadmission (r=0.55, P=0.001; r=0.35, P=0.04; r=0.39, P=0.02). There was no correlation between FVH score and Δφ, NIHSSdischarged, infarct volume (P＞0.05) whether overall or separately analysis. APCVs score was the influencing factor of FVH score (B=0.48, P=0.002).Conclusions The ranges of FVH and APCVs are related to the stenosis of the responsible artery. The larger territory of FVH is consistent with more serious hypoxia and clinical status.

[Keywords] cerebral infarction；magnetic resonance imaging；vascular hyperintensities；susceptibility-weighted imaging；oxygen metabolism

Contributor Information

CHANG Peipei MIAO Yanwei^* JIANG Yuhan CHE Yiwei GAO Bingbing CHEN Lihua SONG Qingwei LIU Ailian

The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

Miao YW, E-mail: ywmiao716@163.com

Conflicts of interest None.

Publication Information

This work was part of National Natural Science Foundation of China (No. 81671646).

Received 2020-11-23

Accepted 2021-01-27

DOI: 10.12015/issn.1674-8034.2021.06.002

Text

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