Share：
Share this content in WeChat
X
[Chinese][PDF]102181
• Clinical Article •
Contrast study using the resting-state fractional amplitude of low-frequency fluctuations between treatment-naive patients with schizophrenia and obsessive-compulsive disorder
YU Xiaoman  HUANG Haixia  TIAN Lin  ZUO Xiang  WANG Shuai  ZHANG Yangyang  ZHOU Zhenhe 

Cite this article as: Yu XM, Huang HX, Tian L, et al. Contrast study using the resting-state fractional amplitude of low-frequency fluctuations between treatment-naive patients with schizophrenia and obsessive-compulsive disorder[J]. Chin J Magn Reson Imaging, 2021, 12(6): 16-21. DOI:10.12015/issn.1674-8034.2021.06.004.


[Abstract] Objective To explore the traits of fractional amplitude of low-frequency fluctuations (fALFF) in treatment-naive patients with schizophrenia (SZ) and obsessive-compulsive disorder (OCD). Materials andMethods In this study, 22 treatment-naive patients with SZ, 27 treatment-naive patients with OCD and 60 healthy controls were recruited and scanned with a 3.0 T MRI scanner. The fALFF values of the three groups of subjects were compared, and Post-hoc analysis was performed based on covariance analysis. The results were all corrected by AlphaSim multiple comparisons. The partial correlation analyses were conducted between fALFF values of significant differences in brain regions and the clinical symptoms and course of disease of the two patient groups, and age, sex and years of education were taken as covariates.Results The brain regions showing significant differences among three groups were located in the right middle frontal gyrus/superior frontal gyrus, right lingual gyrus/cerebellum 4—5, right angular gyrus/supramarginal gyrus, right precuneus/posterior cingulate cortex/middle cingulate cortex, superior temporal gyrus/middle temporal gyrus/hippocampus (AlphaSim corrected, P＜0.01). Compared with the healthy group, the SZ group showed significantly decreased fALFF in the right middle frontal gyrus, right superior temporal gyrus/hippocampus/middle temporal gyrus, right supramarginal gyrus, right precuneus, right lingual gyrus and right angular gyrus (AlphaSim corrected, P＜0.01). Compared with the healthy group, the OCD group showed significantly increased fALFF in the right angular gyrus, right superior frontal gyrus and right middle frontal gyrus, and significantly decreased fALFF in the right lingual gyrus (AlphaSim corrected, P＜0.01). Compared with the SZ group, the OCD group showed significantly increased fALFF in the right superior frontal gyrus/middle frontal gyrus, right supramarginal gyrus/angular gyrus, right hippocampus/superior temporal gyrus/middle temporal gyrus, right posterior cingulate gyrus and right middle cingulate cortex, and significantly decreased fALFF in the right cerebellum 4—5 (AlphaSim corrected, P＜0.01). The results of partial correlation analysis showed that the fALFF values of the right angular gyrus/supramarginal gyrus in SZ patients were positively correlated with the course of the disease (r=0.507, P=0.027).Conclusions Treatment-naive patients with SZ and OCD showed different patterns of fALFF changes in resting state. Compared with patients with OCD, patients with SZ had more impaired brain regions of spontaneous brain activity.
[Keywords] schizophrenia；obsessive-compulsive disorder；fractional amplitude of low-frequency fluctuations；resting-state functional magnetic resonance imaging

YU Xiaoman1   HUANG Haixia2   TIAN Lin1   ZUO Xiang2   WANG Shuai1   ZHANG Yangyang1   ZHOU Zhenhe1*  

1 Department of Psychiatry, Affiliated Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, China

2 Department of Imaging, East China sanatorium, Wuxi 214100, China

Zhou ZH, E-mail: zhouzh@njmu.edu.cn

Conflicts of interest   None.

This work was part of National Natural Science Foundation of China (No. 81871081, 81301148) and Wuxi City "Double Hundred" Young and Middle-Aged Medical and Health Top Talent Funding Project.
Received  2021-02-09
Accepted  2021-03-19
DOI: 10.12015/issn.1674-8034.2021.06.004
Cite this article as: Yu XM, Huang HX, Tian L, et al. Contrast study using the resting-state fractional amplitude of low-frequency fluctuations between treatment-naive patients with schizophrenia and obsessive-compulsive disorder[J]. Chin J Magn Reson Imaging, 2021, 12(6): 16-21. DOI:10.12015/issn.1674-8034.2021.06.004.

1
Hawco C, Voineskos AN, Radhu N, et al. Age and gender interactions in white matter of schizophrenia and obsessive compulsive disorder compared to non-psychiatric controls: commonalities across disorders[J]. Brain Imaging Behavior, 2017, 11(6): 1836-1848. DOI: 10.1007/s11682-016-9657-8.
2
Cheng YF, Chen VC, Yang YH, et al. Risk of schizophrenia among people with obsessive-compulsive disorder: A nationwide population-based cohort study[J]. Schizophrenia Res, 2019, 209: 58-63. DOI: 10.1016/j.schres.2019.05.024.
3
Poyurovsky M, Zohar J, Glick I, et al. Obsessive-compulsive symptoms in schizophrenia: implications for future psychiatric classifications[J]. Comprehensive Psychia, 2012, 53(5): 480-483. DOI: 10.1016/j.comppsych.2011.08.009.
4
Qin J, Sui J, Ni H, et al. The shared and distinct white matter networks between drug-naive patients with obsessive-compulsive disorder and schizophrenia[J]. Front Neurosci, 2019, 13: 96. DOI: 10.3389/fnins.2019.00096.
5
Wang YM, Zou LQ, Xie WL, et al. Altered functional connectivity of the default mode network in patients with schizo-obsessive comorbidity: A comparison between schizophrenia and obsessive-compulsive disorder[J]. Schizophrenia Bulletin, 2019, 45(1): 199-210. DOI: 10.1093/schbul/sbx194.
6
Meier SM, Petersen L, Pedersen MG, et al. Obsessive-compulsive disorder as a risk factor for schizophrenia: a nationwide study[J]. JAMA Psychiatry, 2014, 71(11): 1215-1221. DOI: 10.1001/jamapsychiatry.2014.1011.
7
Li YN, Fan FM, Feng ZY, et al. Resting state functional magnetic resonance imaging study of amplitude of low-frequency fluctuation and fractional amplitude of low-frequency fluctuation in schizophrenia with violent behaviors[J]. Chin J Psychiatry, 2020, 53(1): 16-22. DOI: 10.3760/cma.j.issn.1006-7884.2020.01.004.
8
Moreira PS, Marques P, Magalhães R, et al. The resting-brain of obsessive-compulsive disorder[J]. Psychiatry Res Neuroimaging, 2019, 290: 38-41. DOI: 10.1016/j.pscychresns.2019.06.008.
9
Zou QH, Zhu CZ, Yang Y, et al. An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: fractional ALFF[J]. J Neurosci Method, 2008, 172(1): 137-141. DOI: 10.1016/j.jneumeth.2008.04.012.
10
Zhang XX, Li J, Liao JM, et al. Abnormal gray matter volume and regional homogeneity of resting fMRI in patients with schizophrenia and obsessive-compulsive disorder[J]. Chin Mental Health J, 2017, 31(10): 768-774. DOI: 10.3969/j.issn.1000-6729.2017.10.004.
11
Egorova N, Veldsman M, Cumming T, et al. Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression[J]. NeuroImage Clin, 2017, 16(C): 116-124. DOI: 10.1016/j.nicl.2017.07.014.
12
Yu R, Chien YL, Wang HL, et al. Frequency-specific alternations in the amplitude of low-frequency fluctuations in schizophrenia[J]. Hum Brain Mapping, 2014, 35(2): 627-637. DOI: 10.1002/hbm.22203.
13
Xu Y, Zhuo C, Qin W, et al. Altered spontaneous brain activity in schizophrenia: A meta-analysis and a large-sample study[J]. BioMed Res Int, 2015, 2015: 204628. DOI: 10.1155/2015/204628.
14
Qiu L, Fu X, Wang S, et al. Abnormal regional spontaneous neuronal activity associated with symptom severity in treatment-naive patients with obsessive-compulsive disorder revealed by resting-state functional MRI[J]. Neurosci Lett, 2017, 640: 99-104. DOI: 10.1016/j.neulet.2017.01.024.
15
Zhang H, Wang B, Li K, et al. Altered functional connectivity between the cerebellum and the cortico-striato-thalamo-cortical circuit in obsessive-compulsive disorder[J]. Front Psychiatry, 2019, 10: 522. DOI: 10.3389/fpsyt.2019.00522.
16
Wang Y, Zhu W, Xiao M, et al. Hostile attribution bias mediates the relationship between structural variations in the left middle frontal gyrus and trait angry rumination[J]. Front Psychology, 2018, 9: 526. DOI: 10.3389/fpsyg.2018.00526.
17
Liang Y, Shao R, Zhang Z, et al. Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study[J]. Arch Med Sci, 2019, 15(1): 126-133. DOI: 10.5114/aoms.2018.73422.
18
Gonçalves OF, Sousa S, Carvalho S, et al. Alterations of gray and white matter morphology in obsessive compulsive disorder[J]. Psicothema, 2017, 29(1): 35-42. DOI: 10.7334/psicothema2016.86.
19
Gonçalves ÓF, Soares JM, Carvalho S, et al. Brain activation of the defensive and appetitive survival systems in obsessive compulsive disorder[J]. Brain Imaging Behavior, 2015, 9(2): 255-263. DOI: 10.1007/s11682-014-9303-2.
20
van Kemenade BM, Arikan BE, Kircher T, et al. The angular gyrus is a supramodal comparator area in action-outcome monitoring[J]. Brain Struct Function, 2017, 222(8): 3691-3703. DOI: 10.1007/s00429-017-1428-9.
21
Ren W, Lui S, Deng W, et al. Anatomical and functional brain abnormalities in drug-naive first-episode schizophrenia[J]. Am J Psychiatry, 2013, 170(11): 1308-1316. DOI: 10.1176/appi.ajp.2013.12091148.
22
Meng Z, Zhang Z, Fan Q, et al. Altered fractional amplitude of low frequency fluctuations in unmedicated female patients with obsessive-compulsive disorder[J]. Annual Int Confer IEEE Engineering in Med Biology Soc, 2018, 2018: 1144-1147. DOI: 10.1109/embc.2018.8512490.
23
Hoptman MJ, Zuo XN, Butler PD, et al. Amplitude of low-frequency oscillations in schizophrenia: a resting state fMRI study[J]. Schizophrenia Res, 2010, 117(1): 13-20. DOI: 10.1016/j.schres.2009.09.030.
24
Ha TH, Yoon U, Lee KJ, et al. Fractal dimension of cerebral cortical surface in schizophrenia and obsessive-compulsive disorder[J]. Neurosci Lett, 2005, 384(1-2): 172-176. DOI: 10.1016/j.neulet.2005.04.078.
25
Riffkin J, Yücel M, Maruff P, et al. A manual and automated MRI study of anterior cingulate and orbito-frontal cortices, and caudate nucleus in obsessive-compulsive disorder: comparison with healthy controls and patients with schizophrenia[J]. Psychiatry Res, 2005, 138(2): 99-113. DOI: 10.1016/j.pscychresns.2004.11.007.
26
Picó-Pérez M, Moreira PS, de Melo Ferreira V, et al. Modality-specific overlaps in brain structure and function in obsessive-compulsive disorder: Multimodal meta-analysis of case-control MRI studies[J]. Neurosci Biobehavioral Reviews, 2020, 112: 83-94. DOI: 10.1016/j.neubiorev.2020.01.033.
27
Torrey EF. Schizophrenia and the inferior parietal lobule[J]. Schizophrenia Res, 2007, 97(1-3): 215-225. DOI: 10.1016/j.schres.2007.08.023.

PREV Computational fluid dynamics and functional outcome in atherosclerotic middle cerebral artery stenosis: A correlation study
NEXT Changes of iron in deep gray matter nuclei of children aged 0—6 years: Quantitative susceptibility mapping versus R2*
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn