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• Clinical Article •
Contrast study using the resting-state fractional amplitude of low-frequency fluctuations between treatment-naive patients with schizophrenia and obsessive-compulsive disorder
YU Xiaoman  HUANG Haixia  TIAN Lin  ZUO Xiang  WANG Shuai  ZHANG Yangyang  ZHOU Zhenhe 

Cite this article as: Yu XM, Huang HX, Tian L, et al. Contrast study using the resting-state fractional amplitude of low-frequency fluctuations between treatment-naive patients with schizophrenia and obsessive-compulsive disorder[J]. Chin J Magn Reson Imaging, 2021, 12(6): 16-21. DOI:10.12015/issn.1674-8034.2021.06.004.


[Abstract] Objective To explore the traits of fractional amplitude of low-frequency fluctuations (fALFF) in treatment-naive patients with schizophrenia (SZ) and obsessive-compulsive disorder (OCD). Materials andMethods In this study, 22 treatment-naive patients with SZ, 27 treatment-naive patients with OCD and 60 healthy controls were recruited and scanned with a 3.0 T MRI scanner. The fALFF values of the three groups of subjects were compared, and Post-hoc analysis was performed based on covariance analysis. The results were all corrected by AlphaSim multiple comparisons. The partial correlation analyses were conducted between fALFF values of significant differences in brain regions and the clinical symptoms and course of disease of the two patient groups, and age, sex and years of education were taken as covariates.Results The brain regions showing significant differences among three groups were located in the right middle frontal gyrus/superior frontal gyrus, right lingual gyrus/cerebellum 4—5, right angular gyrus/supramarginal gyrus, right precuneus/posterior cingulate cortex/middle cingulate cortex, superior temporal gyrus/middle temporal gyrus/hippocampus (AlphaSim corrected, P＜0.01). Compared with the healthy group, the SZ group showed significantly decreased fALFF in the right middle frontal gyrus, right superior temporal gyrus/hippocampus/middle temporal gyrus, right supramarginal gyrus, right precuneus, right lingual gyrus and right angular gyrus (AlphaSim corrected, P＜0.01). Compared with the healthy group, the OCD group showed significantly increased fALFF in the right angular gyrus, right superior frontal gyrus and right middle frontal gyrus, and significantly decreased fALFF in the right lingual gyrus (AlphaSim corrected, P＜0.01). Compared with the SZ group, the OCD group showed significantly increased fALFF in the right superior frontal gyrus/middle frontal gyrus, right supramarginal gyrus/angular gyrus, right hippocampus/superior temporal gyrus/middle temporal gyrus, right posterior cingulate gyrus and right middle cingulate cortex, and significantly decreased fALFF in the right cerebellum 4—5 (AlphaSim corrected, P＜0.01). The results of partial correlation analysis showed that the fALFF values of the right angular gyrus/supramarginal gyrus in SZ patients were positively correlated with the course of the disease (r=0.507, P=0.027).Conclusions Treatment-naive patients with SZ and OCD showed different patterns of fALFF changes in resting state. Compared with patients with OCD, patients with SZ had more impaired brain regions of spontaneous brain activity.
[Keywords] schizophrenia；obsessive-compulsive disorder；fractional amplitude of low-frequency fluctuations；resting-state functional magnetic resonance imaging

YU Xiaoman1   HUANG Haixia2   TIAN Lin1   ZUO Xiang2   WANG Shuai1   ZHANG Yangyang1   ZHOU Zhenhe1*  

1 Department of Psychiatry, Affiliated Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, China

2 Department of Imaging, East China sanatorium, Wuxi 214100, China

Zhou ZH, E-mail: zhouzh@njmu.edu.cn

Conflicts of interest   None.

This work was part of National Natural Science Foundation of China (No. 81871081, 81301148) and Wuxi City "Double Hundred" Young and Middle-Aged Medical and Health Top Talent Funding Project.
Received  2021-02-09
Accepted  2021-03-19
DOI: 10.12015/issn.1674-8034.2021.06.004
Cite this article as: Yu XM, Huang HX, Tian L, et al. Contrast study using the resting-state fractional amplitude of low-frequency fluctuations between treatment-naive patients with schizophrenia and obsessive-compulsive disorder[J]. Chin J Magn Reson Imaging, 2021, 12(6): 16-21. DOI:10.12015/issn.1674-8034.2021.06.004.

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