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• Clinical Article •
Changes of iron in deep gray matter nuclei of children aged 0—6 years: Quantitative susceptibility mapping versus R2
NING Ning  JIN Chao  ZHANG Weishan  ZHANG Lei  WU Peng  GUO Hua  LIU Congcong  WU Xiangyu  YANG Jian 

Cite this article as: Ning N, Jin C, Zhang WS, et al. Changes of iron in deep gray matter nuclei of children aged 0—6 years: Quantitative susceptibility mapping versus R2*[J]. Chin J Magn Reson Imaging, 2021, 12(6): 22-26. DOI:10.12015/issn.1674-8034.2021.06.005.


[Abstract] Objective To observe the age-related variation of the iron in deep gray matter nuclei of children aged 0—6 years by measuring the susceptibility and R2* values on quantitative susceptibility mapping (QSM) and R2* maps, and to compare their performances. Materials andMethods Eighty-seven subjects (26 males/61 females) aged from 1 month to 6 years were enrolled in this study. The subjects were divided into two groups (from 1 month to 1-year-old and from ＞1-year-old to 6 years old). Susceptibility and R2* values of caudate nucleus, putamen, globus pallidus and thalamus were measured and analyzed. The relation of the two parameters and age were explored.Results From 1 month to 1-year-old, the susceptibility value of QSM in globus pallidus showed significantly positive correlation with age, as well as the R2* values in deep gray nuclei (all P＜0.001). From ＞1-year-old to 6 years, the susceptibility and R2* values in each deep gray nucleus exhibited significantly positive correlations with age (all P＜0.05) and the correlation coefficients between susceptibility values and age were higher than R2* values in caudate nucleus, putamen and globus pallidus.Conclusions Compared with the R2* values which could be influenced by brain water content, QSM may be a more preferable method for estimating the changes of iron in deep gray matter nuclei of children aged 0—6 years.
[Keywords] quantitative susceptibility mapping；iron；deep gray nuclei；children；transverse relaxation rate；magnetic resonance imaging

NING Ning1, 2   JIN Chao1   ZHANG Weishan1   ZHANG Lei1   WU Peng3   GUO Hua3   LIU Congcong1   WU Xiangyu2   YANG Jian1*  

1 Department of Radiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

2 Department of Nuclear Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China

3 Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing 100085, China

Yang J, E-mail: cjr.yangjian@vip.163.com

Conflicts of interest   None.

This work was part of National Natural Science Found (No. 81771810, 81971581); National Key Research and Development Program of China (No. 2016YFC0100300); Natural Science Foundation of Shaanxi Province (No.2019JM-002); Innovation Capability Support Program of Shaanxi (No. 2019TD-018).
Received  2021-01-28
Accepted  2021-04-19
DOI: 10.12015/issn.1674-8034.2021.06.005
Cite this article as: Ning N, Jin C, Zhang WS, et al. Changes of iron in deep gray matter nuclei of children aged 0—6 years: Quantitative susceptibility mapping versus R2*[J]. Chin J Magn Reson Imaging, 2021, 12(6): 22-26. DOI:10.12015/issn.1674-8034.2021.06.005.

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