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• Clinical Article •
Study on the relationship between epicardial adipose tissue and left ventricular remodeling in hypertrophic cardiomyopathy based on T1 mapping technology
CHEN Yanfei  ZHOU Yingxue  LIU Pengfei 

Cite this article as: Chen YF, Zhou YX, Liu PF. Study on the relationship between epicardial adipose tissue and left ventricular remodeling in hypertrophic cardiomyopathy based on T1 mapping technology[J]. Chin J Magn Reson Imaging, 2021, 12(6): 34-37. DOI:10.12015/issn.1674-8034.2021.06.007.


[Abstract] Objective To investigate the effect of epicardial adipose tissue (EAT) on left ventricular remodeling in hypertrophic cardiomyopathy (HCM) using T1 mapping technology. Materials andMethods The EAT volume and extracellular volume fraction (ECV) of 52 patients diagnosed with HCM in our hospital were measured by cine-MRI, modified Look-Locker inverse recovery T1 mapping sequence. The level of left ventricular fibrosis was measured by ECV. EAT was divided into high and low groups according to the median, and the influence of EAT and related clinical factors on myocardial ECV value was evaluated. Use linear regression to analyze the collinearity of the above statistically significant variables. In addition, the difference of obstructive myocardial hypertrophy between high and low EAT groups was further compared.Results The ECV value of myocardium in the high EAT group was higher than that in the low EAT group (P=0.003), and more obstructive hypertrophy occurred in the high EAT group than in the low EAT group (P=0.012). The ECV of male was higher than that of female (P=0.047). There was no multicollinearity between gender and EAT (tolerance≥0.1, VIF≤5). The remaining clinical factors had no significant correlation with ECV (P＞0.05).Conclusions The incidence of obstructive myocardial hypertrophy in patients with high EAT is increased, which is an independent risk factor of HCM interstitial fibrosis.
[Keywords] hypertrophic cardiomyopathy；epicardial adipose tissue；extracellular volume fraction；fibrosis；magnetic resonance imaging

CHEN Yanfei   ZHOU Yingxue   LIU Pengfei*  

Department of Magnetic Resonance, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Liu PF, E-mail:Pfeiliu@hotmail.com

Conflicts of interest   None.

This work was part of Scientific Research Project of Heilongjiang Provincial Health and Family Planning Commission (No. 2018412).
Received  2020-11-15
Accepted  2021-01-29
DOI: 10.12015/issn.1674-8034.2021.06.007
Cite this article as: Chen YF, Zhou YX, Liu PF. Study on the relationship between epicardial adipose tissue and left ventricular remodeling in hypertrophic cardiomyopathy based on T1 mapping technology[J]. Chin J Magn Reson Imaging, 2021, 12(6): 34-37. DOI:10.12015/issn.1674-8034.2021.06.007.

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