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• Clinical Article •
Study on the relationship between epicardial adipose tissue and left ventricular remodeling in hypertrophic cardiomyopathy based on T1 mapping technology
CHEN Yanfei  ZHOU Yingxue  LIU Pengfei 

Cite this article as: Chen YF, Zhou YX, Liu PF. Study on the relationship between epicardial adipose tissue and left ventricular remodeling in hypertrophic cardiomyopathy based on T1 mapping technology[J]. Chin J Magn Reson Imaging, 2021, 12(6): 34-37. DOI:10.12015/issn.1674-8034.2021.06.007.


[Abstract] Objective To investigate the effect of epicardial adipose tissue (EAT) on left ventricular remodeling in hypertrophic cardiomyopathy (HCM) using T1 mapping technology. Materials andMethods The EAT volume and extracellular volume fraction (ECV) of 52 patients diagnosed with HCM in our hospital were measured by cine-MRI, modified Look-Locker inverse recovery T1 mapping sequence. The level of left ventricular fibrosis was measured by ECV. EAT was divided into high and low groups according to the median, and the influence of EAT and related clinical factors on myocardial ECV value was evaluated. Use linear regression to analyze the collinearity of the above statistically significant variables. In addition, the difference of obstructive myocardial hypertrophy between high and low EAT groups was further compared.Results The ECV value of myocardium in the high EAT group was higher than that in the low EAT group (P=0.003), and more obstructive hypertrophy occurred in the high EAT group than in the low EAT group (P=0.012). The ECV of male was higher than that of female (P=0.047). There was no multicollinearity between gender and EAT (tolerance≥0.1, VIF≤5). The remaining clinical factors had no significant correlation with ECV (P＞0.05).Conclusions The incidence of obstructive myocardial hypertrophy in patients with high EAT is increased, which is an independent risk factor of HCM interstitial fibrosis.
[Keywords] hypertrophic cardiomyopathy；epicardial adipose tissue；extracellular volume fraction；fibrosis；magnetic resonance imaging

CHEN Yanfei   ZHOU Yingxue   LIU Pengfei*  

Department of Magnetic Resonance, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Liu PF, E-mail:Pfeiliu@hotmail.com

Conflicts of interest   None.

This work was part of Scientific Research Project of Heilongjiang Provincial Health and Family Planning Commission (No. 2018412).
Received  2020-11-15
Accepted  2021-01-29
DOI: 10.12015/issn.1674-8034.2021.06.007
Cite this article as: Chen YF, Zhou YX, Liu PF. Study on the relationship between epicardial adipose tissue and left ventricular remodeling in hypertrophic cardiomyopathy based on T1 mapping technology[J]. Chin J Magn Reson Imaging, 2021, 12(6): 34-37. DOI:10.12015/issn.1674-8034.2021.06.007.

1
Schelbert EB, Piehler KM, Zareba KM, et al. Myocardial fibrosis quantified by extracellular volume is associated with subsequent hospitalization for heart failure, death, or both across the spectrum of ejection fraction and heart failure stage[J]. J Am Heart Associat, 2015, 4(12): e002613. DOI: 10.1161/jaha.115.002613.
2
Zhou M, Wang H, Chen J, et al. Epicardial adipose tissue and atrial fibrillation: Possible mechanisms, potential therapies, and future directions[J]. Pacing Clin Electrophysiol, 2020, 43(1): 133-145. DOI: 10.1111/pace.13825.
3
Muhib S, Fujino T, Sato N, et al. Epicardial adipose tissue is associated with prevalent atrial fibrillation in patients with hypertrophic cardiomyopathy [J]. Int Heart J, 2013, 54(5): 297-303. DOI: 10.1536/ihj.54.297.
4
Hernández-Romero D, Orenes-Piñero E, García-Honrubia A, et al. Involvement of the -420C>G RETN polymorphism in myocardial fibrosis in patients with hypertrophic cardiomyopathy[J]. J Intern Med, 2015, 278(1): 50-58. DOI: 10.1111/joim.12334.
5
Elliott PM, Anastasakis A, Borger MA, et al. 2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy: the task force for the diagnosis and management of hypertrophic cardiomyopathy of the European Society of Cardiology (ESC)[J]. Eur Heart J, 2014, 35(39): 2733-2779. DOI: 10.1093/eurheartj/ehu284.
6
Tanaka K, Fukuda D, Sata M. Roles of epicardial adipose tissue in the pathogenesis of coronary atherosclerosis-An update on recent findings[J]. Circ J, 2020, 16(3): 372-375. DOI: 10.1253/circj.CJ-20-0935.
7
Messroghli DR, Moon JC, Ferreira VM, et al. Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)[J]. J Cardiovasc Magn Reson, 2017, 19(1): 631-632. DOI: 10.1186/s12968-017-0389-8.
8
Puntmann VO, Peker E, Chandrashekhar Y, et al. T1 mapping in characterizing myocardial disease: A comprehensive review[J]. Circ Res, 2016, 119(2): 277-299. DOI: 10.1161/CIRCRESAHA.116.307974.
9
Song L, Zou YB, Wang DW, et al. Guidelines for the diagnosis and treatment of adult hypertrophic cardiomyopathy in China[J]. Chin J Cardiol, 2017, 45(12): 1015-1032. DOI: 10.3760/cma.j.issn.0253-3758.2017.12.005.
10
Gastl M, Gruner C, Labucay K, et al. Cardiovascular magnetic resonance T2* mapping for the assessment of cardiovascular events in hypertrophic cardiomyopathy[J]. Open Heart, 2020, 7(1): e001152. DOI: 10.1136/openhrt-2019-001152.
11
Wu JX, Zhang MY, Zhou T. Research progress of visceral adipose tissue and myocardial fibrosis[J]. Chin J Arterioscler, 2019, 27(9): 808-812. DOI: 10.3969/j.issn.1007-3949.2019.09.015.
12
Zhao SH. Magnetic resonance should be used as the gold standard for non-invasive assessment of cardiac structure and function——Interpretation of 2010 Cardiovascular Magnetic Resonance Expert Consensus[J]. Chin Circul J, 2012, 27(z1): 90-92. DOI: 10.3969/j.issn.1000-3614.2012.z1.025.
13
Nakamori S, Dohi K, Ishida M, et al. Native T1 mapping and extracellular volume mapping for the assessment of diffuse myocardial fibrosis in dilated cardiomyopathy[J]. JACC Cardiovasc Imaging, 2018, 11(1): 48-59. DOI: 10.1016/j.jcmg.2017.04.006.
14
Corradi D, Maestri R, Callegari S, et al. The ventricular epicardial fat is related to the myocardial mass in normal, ischemic and hypertrophic hearts[J]. Cardiovasc Pathol, 2004, 13(6): 313-316. DOI: 10.1016/j.carpath.2004.08.005.
15
Ramachandra CJA, Mai Ja KPM, Lin YH, et al. Induced pluripotent pluripotent stem cells for modelling energetic altergetic alterations in hypertrophic cardiomyopathy[J]. Cond Med, 2019, 2(4): 142-151.
16
Gao L, Yang Y, Zhang BW, et al. The clinical and echocardiography features of basal septal hypertrophy[J]. Chin J Ultrasonogr, 2015, 24(5): 369-372. DOI: 10.3760/cma.j.issn.1004-4477.2015.05.001.
17
Kong LQ, Zou LC, Zhang P, et al. Assessment of geometric changes and dynamic deformation of left ventricular and the outflow tract in patiets with isolated basal septal hypertrophy using echocardiography[J]. Chin J Hypertens, 2017, 25(8): 756-761. DOI: 10.16439/j.cnki.1673-7245.2017.08.021.
18
Lu DY, Ventoulis I, Liu H, et al. Sex-specific cardiac phenotype and clinical outcomes in patients with hypertrophic cardiomyopathy[J]. Am Heart J, 2020, 219: 58-69. DOI: 10.1016/j.ahj.2019.10.004.
19
Canepa M, Fumagalli C, Tini G, et al. Temporal trend of age at diagnosis in hypertrophic cardiomyopathy: An analysis of the international sarcomeric human cardiomyopathy registry[J]. Circ Heart Fail, 2020, 13(9): e007230. DOI: 10.1161/CIRCHEARTFAILURE.120.007230.
20
Huang FY, Shah JP, Pu XB, et al. Influence of gender on clinical characteristics and outcomes in Chinese patients with hypertrophic cardiomyopathy[J]. Am J Med Sci, 2020, 29(20): 30190-30197. DOI: 10.1016/j.amjms.2020.05.017.
21
Nogales-Romo MT, Cecconi A, Olivera MJ, et al. Sex differences in cardiac magnetic resonance features in patients with hypertrophic cardiomyopathy[J]. Int J Cardiovasc Imaging, 2020, 36(9): 1751-1759. DOI: 10.1007/s10554-020-01880-y.
22
Homsi R, Sprinkart AM, Gieseke J, et al. 3D-Dixon cardiac magnetic resonance detects an increased epicardial fat volume in hypertensive men with myocardial infarction[J]. Eur J Radiol, 2016, 85(5): 936-942. DOI: 10.1016/j.ejrad.2016.02.016.
23
Ng ACT, Strudwick M, van der Geest RJ, et al. Impact of epicardial adipose tissue, left ventricular myocardial fat content, and interstitial fibrosis on myocardial contractile function[J]. Circ Cardiovasc Imaging, 2018, 11(8): e007372. DOI: 10.1161/CIRCIMAGING.117.007372.

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