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• Original Article •
Correlation analysis of sleep duration of normal elderly and cognitive function brain regions volumes
YUAN Mengya  HONG Bo  ZHANG Wei  LIU An  WANG Jinghua  LIU Yuanyuan  YAN Feng  WANG Tao 

Cite this article as: Yuan MY, Hong B, Zhang W, et al. Correlation analysis of sleep duration of normal elderly and cognitive function brain regions volumes[J]. Chin J Magn Reson Imaging, 2021, 12(6): 62-65, 107. DOI:10.12015/issn.1674-8034.2021.06.012.


[Abstract] Objective To evaluate the association between sleep duration of the normal cognitive elderly and the volumes of the essential brain regions of cognitive function. Materials andMethods One hundred and eighteen elderly subjects with normal cognitive function were included in this study. Freesurfer 6.0 software was used to process MRI data of the participants and segment brain regions. The participants were divided into two groups: short sleeper group (n=46, sleep duration ＜7 hours) and long sleeper group (n=72, sleep duration ≥7 hours). The association between sleep duration and the volumes of the essential brain regions of cognitive function were analyzed by partial correlation respectively.Results When the sleep duration is longer than or equal to 7 hours, it has no significant association with volumes of the essential brain regions of cognitive function. When the sleep duration is shorter than 7 hours, it has a positive association with the volumes of left thalamus (r=0.445, P=0.030), caudate (r=0.371, P=0.048) and the right hippocampus (r=0.334, P=0.076), amygdala (r=0.445, P=0.030), thalamus (r=0.371, P=0.048), and caudate (r=0.414, P=0.036).Conclusions When sleep duration is less than 7 hours, it has a significant association with most of the essential brain regions of cognitive function. Adjusting sleep duration maybe helpful to prevent neurodegenerative changes in related brain regions of cognitive function.
[Keywords] elderly；sleep duration；magnetic resonance imaging；cognitive function；segmentation of brain regions

YUAN Mengya1, 2   HONG Bo1, 2   ZHANG Wei1, 2   LIU An1, 2   WANG Jinghua1, 2   LIU Yuanyuan1, 2   YAN Feng1, 2   WANG Tao1, 2*  

1 Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

2 Alzheimer's Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai 200030, China

Wang T, E-mail: wtshhwy@163.com

Conflicts of interest   None.

This work was part of National Natural Science Foundation of China (No. 81571298) and Shanghai Health System Excellent Talent Training Program (2017BR054).
Received  2021-02-18
Accepted  2021-03-19
DOI: 10.12015/issn.1674-8034.2021.06.012
Cite this article as: Yuan MY, Hong B, Zhang W, et al. Correlation analysis of sleep duration of normal elderly and cognitive function brain regions volumes[J]. Chin J Magn Reson Imaging, 2021, 12(6): 62-65, 107. DOI:10.12015/issn.1674-8034.2021.06.012.

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