Share：
Share this content in WeChat
X
[Chinese][PDF]955126
• Original Article •
Acupuncture changes the functional connectivity of the right insula in asthma: A fMRI study
WEI Xiangyu  CHEN Hui  GONG Zhigang  WANG Hui  HUANG Yanwen  ZHAN Songhua 

Cite this article as: Wei XY, Chen H, Gong ZG, et al. Acupuncture changes the functional connectivity of the right insula in asthma: A fMRI study[J]. Chin J Magn Reson Imaging, 2021, 12(6): 72-77. DOI:10.12015/issn.1674-8034.2021.06.014.


[Abstract] Objective To observe the instant adjustive effect of electroacupuncture (EA) on the right insula in patients with asthma (PA) using functional connectivity (FC). Materials andMethods The baseline resting-state fMRI (rs-fMRI) data of the PA group and health controls (HCs) were collected. Then the PA group received the second phase of rs-fMRI scanning after EA at Dazhui, Fengmen and Feishu for 30 minutes. The FC analysis takes subregions of right insula as seed point: Ventral Anterior Insula (vAI); Dorsal Anterior Insula (dAI); Posterior Insula (PI) .Results ①Compared with the HCs, the FC between vAI and left pallidus was weakened in PA group(t=-3.85, P＜0.05), the FC between dAI and right precentral gyrus (t=3.27, P＜0.05), right angular gyrus (t=3.48, P＜0.05) and right superior frontal gyrus (t=3.41, P＜0.05) were enhanced, and the FC between PI and right inferior temporal gyrus (t=-3.94, P＜0.05), right superior temporal gyrus (t=-3.15, P＜0.05) was weakened. ②In the group of PA, there was no significant difference brain regions between vAI and whole brain FC (P＞0.05). the FC between dAI and left precentral gyrus (t=3.92, P＜0.05), left posterior cingulate gyrus (t=3.49, P＜0.05), left angular gyrus (t=3.84, P＜0.05), right precuneus (t=4.01, P＜0.05) were enhanced after EA, and the FC between PI and postcentral gyrus (left: t=4.09, right: t=4.25, P＜0.05), right precentral gyrus (t=4.09, P＜0.05), left posterior cingulate gyrus (t=3.65, P＜0.05) was enhanced.Conclusions EA at Dazhui, Fengmen and Feishu can enhance the FC between the right insula subregions and the brain regions related to default mode network, which may be the potential mechanism of acupuncture on the brain effect of asthma.
[Keywords] asthma；functional magnetic resonance imaging；acupuncture；functional connectivity；insula

WEI Xiangyu   CHEN Hui   GONG Zhigang   WANG Hui   HUANG Yanwen   ZHAN Songhua*  

Department of Radiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Zhan SH, E-mail: zhansonghua@sina.com

Conflicts of interest   None.

This work was part of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, National Natural Science Foundation Incubation Project (No. SGYYYX-202001); Shanghai 2018 Scientific and Technological Innovation Action Plan in the Field of Clinical Medicine (No. 18401970900); Shanghai University of Traditional Chinese Medicine Major Achievement Project (No. ZDCG201701).
Received  2020-11-24
Accepted  2021-01-27
DOI: 10.12015/issn.1674-8034.2021.06.014
Cite this article as: Wei XY, Chen H, Gong ZG, et al. Acupuncture changes the functional connectivity of the right insula in asthma: A fMRI study[J]. Chin J Magn Reson Imaging, 2021, 12(6): 72-77. DOI:10.12015/issn.1674-8034.2021.06.014.

1
Zhang J, Shao S, Ren Z, et al. Comparison between "five needles therapy" and conventional acupuncture for individual symptoms and signs of asthma of latent cold phlegm-fluid in the lung[J]. Chin Acup Moxib, 2018, 38(1): 7-11. DOI: 10.13703/j.0255-2930.2018.01.002.
2
Hu XJ, Shao SJ, Hua JS, et al. Effect of acupuncture and moxibustion at "Feishu""Dazhui"and "Fengmen"on the expression of CC chemokine ligand 1 and CC chemokine receptor 8 in lung tissue of rats with asthma[J]. Zhen Ci Yan Jiu, 2020, 45(5): 363-367. DOI: 10.13702/j.1000-0607.190394.
3
Liu YL, Zhang LD, Ma TM, et al. Feishu acupuncture inhibits acetylcholine synthesis and restores muscarinic acetylcholine receptor M2 expression in the lung when treating allergic asthma[J]. Inflammation, 2018, 41(3): 741-750. DOI: 10.1007/s10753-017-0726-y.
4
Nurwati I, Muthmainah M, Huda KN. Acupuncture for asthma: Its potential significance in clinical practice[J]. Med Acupunct, 2020, 32(5): 272-279. DOI: 10.1089/acu.2020.1443.
5
Cui J, Dong M, Yi L, et al. Acupuncture inhibited airway inflammation and group 2 innate lymphoid cells in the lung in an ovalbumin-induced murine asthma model[J]. Acupunct Med, 2020 Jun 15. 964528420924033. DOI: 10.1177/0964528420924033.
6
Sun YB, Liu ZY, Chen J, et al. The effect of social comparison subjects to regret emotional volatility:a rs-fMRI study[J]. Chin J Magn Reson Imaging, 2019, 10(11): 801-806. DOI: 10.12015/issn.1674-8034.2019.11.001.
7
Ritz T, Kroll JL, Patel SV, et al. Central nervous system signatures of affect in asthma: associations with emotion-induced bronchoconstriction, airway inflammation, and asthma control[J]. J Appl Physiol (1985), 2019, 126(6): 1725-1736. DOI: 10.1152/japplphysiol.01018.2018.
8
Li S, Lv P, He M, et al. Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study[J]. Front Med, 2020, 14(6): 792-801. DOI: 10.1007/s11684-020-0745-1.
9
Deen B, Pitskel NB, Pelphrey KA. Three systems of insular functional connectivity identified with cluster analysis[J]. Cerebral Cortex, 2010, 21(7): 1498-1506. DOI: 10.1093/cercor/bhq186.
10
Sastre J, Crespo A, Fernandez-Sanchez A, et al. Anxiety, depression, and asthma control: Changes after standardized treatment[J]. J Allergy Clin Immunol Pract, 2018, 6(6): 1953-1959. DOI: 10.1016/j.jaip.2018.02.002.
11
Rosenkranz MA, Busse WW, Sheridan JF, et al. Are there neurophenotypes for asthma? Functional brain imaging of the interaction between emotion and inflammation in asthma[J]. PLoS One, 2012, 7(8): e40921. DOI: 10.1371/journal.pone.0040921.
12
Zhang Y, Yang Y, Bian R, et al. Abnormal functional connectivity of ventral anterior insula in asthmatic patients with depression[J]. Neural Plast, 2017, 2017: 1-11. DOI: 10.1155/2017/7838035.
13
Stoeckel MC, Esser RW, Gamer M, et al. Breathlessness amplifies amygdala responses during affective processing[J]. Psychophysiology, 2018, 55(9): e13092. DOI: 10.1111/psyp.13092.
14
Royer J, Paquola C, Lariviere S, et al. Myeloarchitecture gradients in the human insula: Histological underpinnings and association to intrinsic functional connectivity[J]. Neuroimage, 2020, 216: 116859. DOI: 10.1101/839837.
15
Uddin LQ, Nomi JS, Hebert-Seropian B, et al. Structure and function of the human insula[J]. J Clin Neurophysiol, 2017, 34(4): 300-306. DOI: 10.1097/WNP.0000000000000377.
16
Ghaziri J, Tucholka A, Girard G, et al. The corticocortical structural connectivity of the human insula[J]. Cereb Cortex, 2017, 27(2): 1216-1228. DOI: 10.1093/cercor/bhv308.
17
Pujol S, Cabeen R, Sebille SB, et al. In vivo exploration of the connectivity between the subthalamic nucleus and the globus pallidus in the human brain using multi-fiber tractography[J]. Front Neuroanat, 2016, 10: 119. DOI: 10.3389/fnana.2016.00119.
18
Igelstrom KM, Graziano M. The inferior parietal lobule and temporoparietal junction: A network perspective[J]. Neuropsychologia, 2017, 105: 70-83. DOI: 10.1016/j.neuropsychologia.2017.01.001.
19
Zhang Y, Yang Y, Bian R, et al. Group cognitive behavior therapy reversed insula subregions functional connectivity in asthmatic patients[J]. Front Aging Neurosci, 2017, 9: 105. DOI: 10.3389/fnagi.2017.00105.
20
Zou Y, Tang W, Li X, et al. Acupuncture reversible effects on altered default mode network of chronic migraine accompanied with clinical symptom relief[J]. Neural Plast, 2019, 2019: 5047463. DOI: 10.1155/2019/5047463.
21
Liu CH, Yeh TC, Kung YY, et al. Changes in resting-state functional connectivity in nonacute sciatica with acupuncture modulation: A preliminary study[J]. Brain Behav, 2020, 10(2): e1494. DOI: 10.1002/brb3.1494.
22
Yu S, Xie M, Liu S, et al. Resting-state functional connectivity patterns predict acupuncture treatment response in primary dysmenorrhea[J]. Front Neurosci, 2020, 14: 559191. DOI: 10.3389/fnins.2020.559191.
23
Zhang Y, Zhou W, Wang S, et al. The roles of subdivisions of human insula in emotion perception and auditory processing[J]. Cereb Cortex, 2019, 29(2): 517-528. DOI: 10.1093/cercor/bhx334.
24
Li R, Utevsky AV, Huettel SA, et al. Developmental maturation of the precuneus as a functional core of the default mode network[J]. J Cogn Neurosci, 2019, 31(10): 1506-1519. DOI: 10.1162/jocn_a_01426.
25
Yamashita KI, Uehara T, Prawiroharjo P, et al. Functional connectivity change between posterior cingulate cortex and ventral attention network relates to the impairment of orientation for time in Alzheimer's disease patients[J]. Brain Imaging Behav, 2019, 13(1): 154-161. DOI: 10.1007/s11682-018-9860-x.

PREV Quantitative experimental study in a rabbit model of liver fibrosis by DCE-MRI with Gd-EOB-DTPA
NEXT A machine learning model for early diagnosis of Alzheimer,s disease
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn